Shahid Shah
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View article: Current pattern of off-label drug use among hospitalized pediatric patients: a short-term longitudinal study
Current pattern of off-label drug use among hospitalized pediatric patients: a short-term longitudinal study Open
View article: Efficacy of Suprachoroidal Triamcinolone Acetonide Injections in Resistant Diabetic Macular Edema
Efficacy of Suprachoroidal Triamcinolone Acetonide Injections in Resistant Diabetic Macular Edema Open
Localized drug delivery through the suprachoroidal space can be used for more targeted therapies whilst minimize exposure to the healthy tissues. Objectives: To determine the efficacy of suprachoroidal triamcinolone injection given by the …
View article: Long-term Postoperative Outcomes of Pediatric Cataract Extraction with IOL Implantation in a Tertiary Eye Care Centre at Karachi
Long-term Postoperative Outcomes of Pediatric Cataract Extraction with IOL Implantation in a Tertiary Eye Care Centre at Karachi Open
Cataracts in the pediatric age group present with challenges distinct from the adult age group. Objectives: To determine the long-term postoperative outcomes of pediatric cataract extraction with IOL implantation at a tertiary eye care cen…
View article: Economic Burden of Acute Myeloid Leukemia in European Union: Results from a Systematic Review of Literature
Economic Burden of Acute Myeloid Leukemia in European Union: Results from a Systematic Review of Literature Open
Registered in PROSPERO under the registration number 'CRD42024537725'.
View article: Effect of Supra Choroid Triamcinolone Acetate On Intraocular Pressure
Effect of Supra Choroid Triamcinolone Acetate On Intraocular Pressure Open
Intraocular pressure is a critical parameter in maintaining the physiological function of the eye. Dysregulation of Intraocular pressure can lead to ocular pathologies. Objective: To evaluate change in intraocular pressure after supra-chor…
View article: Pattern of antibiotic dispensing at pharmacies according to access, watch, reserve (AWaRe) classification: multicenter study after COVID-19 waves in different districts of Pakistan
Pattern of antibiotic dispensing at pharmacies according to access, watch, reserve (AWaRe) classification: multicenter study after COVID-19 waves in different districts of Pakistan Open
View article: Treatment of Blepharoptosis in paediatric patients using modified frontalis sling technique with lid crease creation
Treatment of Blepharoptosis in paediatric patients using modified frontalis sling technique with lid crease creation Open
Purpose: To observe the aesthetic and visual outcomes of a modified frontalis sling technique with lid crease creation in pediatric patients of upper lid drooping associated with weak Levator muscle. Study Design: Quasi experimental study.…
View article: Pattern and associated factors of COVID-19 knowledge, attitude and practice (KAP) among COVID-19-comorbid patients: a systematic review and meta-analysis
Pattern and associated factors of COVID-19 knowledge, attitude and practice (KAP) among COVID-19-comorbid patients: a systematic review and meta-analysis Open
Background The COVID-19 comorbid population is at higher risk of developing severe health issues like acute respiratory distress syndrome, coagulation syndrome, metabolic acidosis, and septic shock, potentially leading to patient death. Pa…
View article: Examining the Influential Role of Family CEO and Investment on Tunneling: A BoundTest Approach
Examining the Influential Role of Family CEO and Investment on Tunneling: A BoundTest Approach Open
Tunneling is one of the ferocious corporate frauds mostly practiced in concentrated firms. This creates principal-principal agency conflict which influences the entire company operation and discourages investors. This study examined whethe…
View article: Treatment gap and barriers to access mental healthcare among women with postpartum depression symptoms in Pakistan
Treatment gap and barriers to access mental healthcare among women with postpartum depression symptoms in Pakistan Open
Background and Objectives Postpartum depression (PPD) is prevalent among women after childbirth, but accessing mental healthcare for PPD is challenging. This study aimed to assess the treatment gap and barriers to mental healthcare access …
View article: A combination of gliclazide and metformin attenuates obesity-induced polycystic ovary syndrome in female Wistar rats
A combination of gliclazide and metformin attenuates obesity-induced polycystic ovary syndrome in female Wistar rats Open
Presently, it is known that the progression of obesity concomitantly leads to polycystic ovary syndrome and infertility. This study aimed to evaluate the potential effects of metformin (M; insulin secretagogues) and gliclazide (G; insulin …
View article: Conjugated Linoleic Acid–Carboxymethyl Chitosan Polymeric Micelles to Improve the Solubility and Oral Bioavailability of Paclitaxel
Conjugated Linoleic Acid–Carboxymethyl Chitosan Polymeric Micelles to Improve the Solubility and Oral Bioavailability of Paclitaxel Open
Oral delivery, the most common method of therapeutic administration, has two significant obstacles: drug solubility and permeability. The challenges of current oral medicine delivery are being tackled through an emerging method that uses s…
View article: Cardioprotective and hypotensive mechanistic insights of hydroethanolic extract of Cucumis melo L. kernels in isoprenaline-induced cardiotoxicity based on metabolomics and in silico electrophysiological models
Cardioprotective and hypotensive mechanistic insights of hydroethanolic extract of Cucumis melo L. kernels in isoprenaline-induced cardiotoxicity based on metabolomics and in silico electrophysiological models Open
Background: Cardiovascular diseases (CVD) continue to threaten health worldwide, and account for a significant portion of deaths and illnesses. In both developing and industrialized nations, they challenge their health systems. There are s…
View article: Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate
Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate Open
Depression is the major mental illness which causes along with loss of interest in daily life, a feeling of hopelessness, appetite or weight changes, anger and irritability. Due to the hepatic first-pass metabolism, the absolute bioavailab…
View article: Assessment of health-related quality of life among patients with obesity, hypertension and type 2 diabetes mellitus and its relationship with multimorbidity
Assessment of health-related quality of life among patients with obesity, hypertension and type 2 diabetes mellitus and its relationship with multimorbidity Open
Obesity, hypertension (HTN) and type 2 diabetes (T2D) are among the multifactorial disorders that occur at higher prevalence in a population. This study aims to assess the health-related quality of life (HRQoL) of patients with obesity, HT…
View article: Fabrication, Characterization and Biomedical Evaluation of a Statistically Optimized Gelatin Scaffold Enriched with Co-Drugs Loaded into Controlled-Release Silica Nanoparticles
Fabrication, Characterization and Biomedical Evaluation of a Statistically Optimized Gelatin Scaffold Enriched with Co-Drugs Loaded into Controlled-Release Silica Nanoparticles Open
The current study focused on the fabrication of a well-designed, biocompatible, physically stable, non-irritating and highly porous gelatin scaffold loaded with controlled-release triamcinolone acetonide (TA) and econazole nitrate (EN) co-…
View article: Disulfide Bridged Nanoparticles of Thiolated Sodium Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: <i>In Vitro</i> and <i>In Vivo</i> Evaluation
Disulfide Bridged Nanoparticles of Thiolated Sodium Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: <i>In Vitro</i> and <i>In Vivo</i> Evaluation Open
Most biopharmaceutics classification system (BCS) class IV drugs have limited oral bioavailability due to poor solubility and poorer permeability. This work aims to investigate the possibility of utilizing disulfide bridged nanoparticles t…
View article: Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders
Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders Open
Patients suffering from chronic diseases are more likely to experience pDDIs due to older age, prolonged treatment, severe illness and greater number of prescribed drugs. The objective of the current study was to assess the prevalence of p…
View article: Development, Optimization and in Vitro-In Vivo Evaluation of Solid Lipid Microparticles for Improved Pharmacokinetic Profile of Bisoprolol
Development, Optimization and in Vitro-In Vivo Evaluation of Solid Lipid Microparticles for Improved Pharmacokinetic Profile of Bisoprolol Open
View article: Assessing Patient Satisfaction with Community Pharmacy Services: A Large Regional Study at Punjab, Pakistan
Assessing Patient Satisfaction with Community Pharmacy Services: A Large Regional Study at Punjab, Pakistan Open
The provision of community pharmacy services to patients was not satisfactory. Furthermore, the absence of pharmacist in the pharmacy and the lack of provision for counseling time raised concerns.
View article: Cellular and non-cellular antioxidant properties of vitamin E loaded metallic- quercetin/polycaprolactone nanoparticles for the treatment of melanogenesis
Cellular and non-cellular antioxidant properties of vitamin E loaded metallic- quercetin/polycaprolactone nanoparticles for the treatment of melanogenesis Open
Inhibition of melanogenesis by quercetin and vitamin E are extensively reported in the literature, independently, with the limitations of their antioxidant potential owing to less permeation, slight solubility in water, decreased bioavaila…
View article: Estimation of Psychological Impairment and Coping Strategies during COVID-19 Pandemic among University Students in Saudi Arabia: A Large Regional Analysis
Estimation of Psychological Impairment and Coping Strategies during COVID-19 Pandemic among University Students in Saudi Arabia: A Large Regional Analysis Open
Background: The COVID-19 pandemic and associated restrictive measures have substantially affected educational processes around the globe, resulting in psychological distress among students. The mental health of students in higher education…
View article: In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization
In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization Open
Present research was planned to assess the in vitro and in vivo anti-arthritic potential of Caralluma tuberculata N. E. Brown. methanolic (CTME) and aqueous (CTAQ) extracts. Chemical characterization was done by high-performance liquid chr…
View article: Nanoparticles of thiolated chitosan for controlled delivery of moxifloxacin: In-vitro and in-vivo evaluation
Nanoparticles of thiolated chitosan for controlled delivery of moxifloxacin: In-vitro and in-vivo evaluation Open
Controlled release drug delivery system of moxifloxacin produces better therapeutic effects and maintain the plasma concentration for prolong period of time. The objective of this work was to formulate nanoparticles of thiolated chitosan (…
View article: Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling
Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling Open
The development of the embryonic lung demands complex endodermal–mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during …
View article: Evaluation of Consumers Perspective on the Consumption of Antibiotics, Antibiotic Resistance, and Recommendations to Improve the Rational use of Antibiotics: An Exploratory Qualitative Study From Post-Conflicted Region of Pakistan
Evaluation of Consumers Perspective on the Consumption of Antibiotics, Antibiotic Resistance, and Recommendations to Improve the Rational use of Antibiotics: An Exploratory Qualitative Study From Post-Conflicted Region of Pakistan Open
Background: Antibiotics misuse is a global challenge, and the situation is likely to deteriorate in conflict zones with insufficient health services. The misuse of antibiotics is not only associated with antimicrobial resistance but may al…
View article: Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections
Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections Open
The occurrence of fungal infections has increased over the past two decades. It is observed that superficial fungal infections are treated by conventional dosage forms, which are incapable of treating deep infections due to the barrier act…
View article: Antibacterial and Wound-Healing Activities of Statistically Optimized Nitrofurazone- and Lidocaine-Loaded Silica Microspheres by the Box–Behnken Design
Antibacterial and Wound-Healing Activities of Statistically Optimized Nitrofurazone- and Lidocaine-Loaded Silica Microspheres by the Box–Behnken Design Open
In the current study, nitrofurazone- (NFZ) and lidocaine-loaded (LD) silica microspheres were fabricated to address pathological indications of skin infections. The microspheres were prepared by the sol–gel method applying the Box–Behnken …
View article: Knowledge, Attitudes and Practices of Pharmacogenomics Among Senior Pharmacy Students: A Cross Sectional Study from Punjab, Pakistan
Knowledge, Attitudes and Practices of Pharmacogenomics Among Senior Pharmacy Students: A Cross Sectional Study from Punjab, Pakistan Open
Background: Pharmacogenomics (PGx) is essential for optimizing drug therapy and reducing unwanted drug side effects.Our aim was to determine the knowledge, attitude and practice of senior pharmacy students in Punjab, Pakistan towards PGx.M…
View article: Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS)
Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) Open
The purpose of the study was to develop an SNEDDS to improve the solubility and bioavailability of pitavastatin. The solubility of pitavastatin in different oils, surfactants, and co-surfactants was determined and a pseudo-ternary phase di…