Xin Wang
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View article: Risk factors for prolonged length of stay after first minimally invasive tubular microdiscectomy in lumbar disc herniation
Risk factors for prolonged length of stay after first minimally invasive tubular microdiscectomy in lumbar disc herniation Open
Background This study was to identify potential risk factors for prolonged length of stay (LOS) in patients with lumbar disc herniation (LDH) after first minimally invasive tubular microdiscectomy (TMD). Demographic data, clinical records,…
View article: Supplementary Figure 15 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Supplementary Figure 15 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Supplementary Figure 15 - (A) Venn diagram depicting number of peaks identified from ChIP-seq in lentiviral control, CS-FL overexpression, and CS-ΔEx4 overexpression groups. (B) Proportion of CS-ΔEx4 peaks associated with promoter regions,…
View article: Data from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Data from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Metabolic reprogramming, notably alterations in the tricarboxylic acid (TCA) cycle, has emerged as a hallmark of cancer that supports tumor growth and metastasis. Despite the TCA cycle being a classical central metabolic pathway, further e…
View article: Supplementary Figure 16 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Supplementary Figure 16 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Supplementary Figure 16 - The original film showing the Cytokine array blotting result.
View article: Supplementary Figure 11 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Supplementary Figure 11 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Supplementary Figure 11 - Metabolic pathways of glycolysis and the TCA cycle, highlighting amino acids, oncometabolites, and metabolic byproducts in close association with CS-ΔEx4 within a cell.
View article: Supplementary Figure 17 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Supplementary Figure 17 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Supplementary Figure 17 - Workflow for small molecule screening
View article: Effects of omega-3 fatty acids on chronic pain: a systematic review and meta-analysis
Effects of omega-3 fatty acids on chronic pain: a systematic review and meta-analysis Open
Background Chronic pain afflicts approximately 20% of the global adult population and is frequently undertreated, with available pharmacologic options often associated with significant long-term adverse effects. Although omega-3 fatty acid…
View article: GraphChain: Large Language Models for Large-scale Graph Analysis via Tool Chaining
GraphChain: Large Language Models for Large-scale Graph Analysis via Tool Chaining Open
Large Language Models (LLMs) face significant limitations when applied to large-scale graphs, struggling with context constraints and inflexible reasoning. We present GraphChain, a framework that enables LLMs to analyze complex graphs thro…
View article: Dye sensitized NaErF4: Ce3+, Yb3+ nanodisks achieve efficient near-infrared IIb region luminescence
Dye sensitized NaErF4: Ce3+, Yb3+ nanodisks achieve efficient near-infrared IIb region luminescence Open
Luminescence in the second near-infrared window (NIR-IIb, 1500–1700 nm) has garnered significant attention in bioimaging due to its advantages of deep tissue penetration and low autofluorescence. However, luminescent materials in this spec…
View article: Gut Microbiome of Two Rodent Species (Niviventer confucianus and Apodemus agrarius) from Two Regions Exhibit Different Structures and Assembly Mechanisms
Gut Microbiome of Two Rodent Species (Niviventer confucianus and Apodemus agrarius) from Two Regions Exhibit Different Structures and Assembly Mechanisms Open
The structure and assembly mechanism of wild animal gut microbiota represent persistent research hotspots. Among, the impact of geographic factors on the bacterial co-occurrence network characteristics and assembly mechanism of the gut mic…
View article: Distinct survival, optimal combination strategy of immunotherapy, and immunophenotype in uncommon and 20ins EGFR-mut lung adenocarcinoma: a multi-center study
Distinct survival, optimal combination strategy of immunotherapy, and immunophenotype in uncommon and 20ins EGFR-mut lung adenocarcinoma: a multi-center study Open
The efficiency and optimal combination strategies of immune checkpoint inhibitors (ICI) in lung adenocarcinoma (LUAD) patients with epidermal growth factor receptor (EGFR) other mutations apart from 19del/L858R (classical), which account f…
View article: A Cascade‐Targeting System Delivering Polyphenol Into the Mitochondria of M1 Macrophages for Inflammatory Bowel Disease Therapy
A Cascade‐Targeting System Delivering Polyphenol Into the Mitochondria of M1 Macrophages for Inflammatory Bowel Disease Therapy Open
Precise intervention targeting the mitochondria of macrophages represents a promising therapeutic strategy to address the challenges of limited clinical efficacy and high risk of adverse reactions in current pharmacological treatments for …
View article: Microglial Deletion of <i>Hrh4</i> Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau
Microglial Deletion of <i>Hrh4</i> Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau Open
Amyloid‐beta (Aβ) and hyperphosphorylated tau (p‐tau) aggregation are hallmark pathogenic events in Alzheimer's disease (AD). Microglial clearance of these toxic aggregates is essential, yet the underlying mechanisms remain poorly understo…
View article: Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients
Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients Open
Despite the lack of predictive biomarkers and a prognostic stratification strategy, immune checkpoint inhibitor (ICI) has shown promise in improving outcomes for patients with limited-stage small cell lung cancer (LS-SCLC). We evaluated th…
View article: Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma
Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma Open
Although genome sequencings have recognized many cancer-associated genes in hepatocellular carcinoma (HCC), distinguishing their functional effect remains challenging. Leveraging on a genome-wide CRISPR knockout (KO) screening, we uncovere…
View article: Hypothalamic subunit volumes in schizophrenia with comorbidity of metabolic syndrome
Hypothalamic subunit volumes in schizophrenia with comorbidity of metabolic syndrome Open
Schizophrenia and metabolic syndrome (MS) are common conditions that frequently co-occur, yet the neurobiological mechanisms underlying their comorbidity remain unclear. This study aimed to investigate whether hypothalamic structural alter…
View article: Development and validation of nomograms for predicting grade ≥3 diarrhea and neutropenia after abemaciclib combined with endocrine therapy for breast cancer: a multicenter retrospective real-world study
Development and validation of nomograms for predicting grade ≥3 diarrhea and neutropenia after abemaciclib combined with endocrine therapy for breast cancer: a multicenter retrospective real-world study Open
Background This study aimed to investigate the risk factors associated with grade ≥3 diarrhea and neutropenia, which are the most common adverse events (AEs) leading to discontinuation and dose reduction in patients with hormone receptor-p…
View article: FC-YOLO: a fast inference backbone and lightweight attention mechanism-enhanced YOLO for detecting gastric adenocarcinoma in pathological image
FC-YOLO: a fast inference backbone and lightweight attention mechanism-enhanced YOLO for detecting gastric adenocarcinoma in pathological image Open
Background Gastric adenocarcinoma (GAC) is a leading cause of cancer-related mortality, but its histopathological diagnosis is challenged by image complexity and a shortage of pathologists. While deep learning models show promise, many are…
View article: Cav1.2 facilitates the binding and internalisation of porcine epidemic diarrhoea virus
Cav1.2 facilitates the binding and internalisation of porcine epidemic diarrhoea virus Open
Porcine epidemic diarrhoea virus (PEDV) has caused substantial economic losses to the global swine industry. The PEDV spike (S) protein mediates viral entry by interacting with host receptors. However, the molecular mechanisms underlying P…
View article: Exploring the survival benefits of surgical treatment for pancreatic adenocarcinoma using the DeepSurv neural network model
Exploring the survival benefits of surgical treatment for pancreatic adenocarcinoma using the DeepSurv neural network model Open
To develop a DeepSurv model for predicting survival in pancreatic adenocarcinoma patients, evaluating the benefit of surgical versus non-surgical treatment across different stages, including stage IV subcategories. Clinical data were extra…
View article: A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Metabolic reprogramming, notably alterations in the tricarboxylic acid (TCA) cycle, has emerged as a hallmark of cancer that supports tumor growth and metastasis. Despite the TCA cycle being a classical central metabolic pathway, further e…
View article: Calcium-sensing receptor AcCaS regulates chloroplast immunity in kiwifruit by competitively binding with Ca2+ or the <i>Psa</i> effector
Calcium-sensing receptor AcCaS regulates chloroplast immunity in kiwifruit by competitively binding with Ca2+ or the <i>Psa</i> effector Open
Activating chloroplast immunity to enhance host resistance offers a novel and sustainable approach for the effective control of kiwifruit bacterial canker (KBC). Chloroplasts serve as a central hub for ROS, SA, and Ca2+ signaling. As a chl…
View article: Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by <i>UGT1A1</i> status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial
Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by <i>UGT1A1</i> status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial Open
Background The optimal regimen and chemotherapy intensity are still under investigation for neoadjuvant treatment of locally advanced rectal cancer (LARC). The CinClare trial has demonstrated improved pathologic complete response (pCR) wit…
View article: Flu-CNN: identifying host specificity of Influenza A virus using convolutional networks
Flu-CNN: identifying host specificity of Influenza A virus using convolutional networks Open
Influenza A viruses (IAVs) have historically posed significant public health threats, causing severe pandemics. Viral host specificity is typically constrained by host barriers, limiting the range of species that can be infected. However, …
View article: miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene
miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene Open
The reproductive potential of bull represents a key economic trait in modern cattle husbandry. The primary determinant of bull reproductive capacity is the proper development of the testes, which is essential for the production of spermato…
View article: Eutrophication-driven biogeochemical processes influencing dissolved organic matter dynamics in a tropical coastal bay: Insights from Lianzhou Bay, northwestern South China Sea
Eutrophication-driven biogeochemical processes influencing dissolved organic matter dynamics in a tropical coastal bay: Insights from Lianzhou Bay, northwestern South China Sea Open
View article: Function of <i>SP1</i> in tumors and focused treatment approaches for immune evasion (Review)
Function of <i>SP1</i> in tumors and focused treatment approaches for immune evasion (Review) Open
Immune escape is a phenomenon in which tumor cells or infections evade detection and clearance by the host immune system in various ways. During an antitumor immune response, cells increase the concentration of pentameric stalk, which enha…
View article: Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes
Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes Open
Osteoarthritis (OA) is a prevalent chronic degenerative joint disease. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated as a crucial contributor to OA progression. Simiao Powder, a classical traditional Chi…
View article: Integrated PTS fire evacuation path planning algorithm
Integrated PTS fire evacuation path planning algorithm Open
Fire evacuation in large-scale buildings presents significant challenges, including prolonged evacuation times, exit congestion, and frequent communication breakdowns. To address these issues, this study proposes a novel hybrid fire evacua…
View article: Epithelial characteristics of ovarian clear cell carcinoma at single-cell resolution
Epithelial characteristics of ovarian clear cell carcinoma at single-cell resolution Open