Maohan Su
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View article: Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine
Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine Open
Biomolecular condensates are membraneless bodies that organize biochemical reactions typically within cells. However, the roles of condensates in extracellular space—where conditions differ substantially from intracellular space—remain poo…
View article: The Golgi Rim is a Precise Tetraplex of Golgin Proteins that Can Self-Assemble into Filamentous Bands
The Golgi Rim is a Precise Tetraplex of Golgin Proteins that Can Self-Assemble into Filamentous Bands Open
Golgin proteins have long been suspected to be organizers of the Golgi stack. Using three-dimensional super-resolution microscopy, we comprehensively localize the human golgin family at the rim of the Golgi apparatus at 10-20 nm resolution…
View article: TUG protein acts through a disordered region to organize the early secretory pathway
TUG protein acts through a disordered region to organize the early secretory pathway Open
The endoplasmic reticulum (ER)-Golgi Intermediate Compartment (ERGIC) is a distinct compartment in mammalian cells, which forms in part by homotypic fusion of ER-derived vesicles and gives rise to the cis cisterna of the Golgi ribbon. How …
View article: VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1
VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1 Open
Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacent membranes, cause Cohen syndrome. VPS13B is known to be concentrated in the Golgi complex, but its precise location within this organelle …
View article: Competition and synergy of Arp2/3 and formins in nucleating actin waves
Competition and synergy of Arp2/3 and formins in nucleating actin waves Open
Actin assembly and dynamics are crucial for maintaining cell structure and changing physiological states. The broad impact of actin on various cellular processes makes it challenging to dissect the specific role of actin regulatory protein…
View article: Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1
Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1 Open
The coordination between actin and microtubule network is crucial, yet this remains a challenging problem to dissect and our understanding of the underlying mechanisms remains limited. In this study, we used travelling waves in the cell co…
View article: VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 Open
Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacent membranes, cause Cohen syndrome. VPS13B is known to be concentrated in the Golgi complex, but its precise location within this organelle …
View article: Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves
Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves Open
The assembly and disassembly of actin filaments and their regulatory proteins are crucial for maintaining cell structure or changing physiological state. However, because of the tremendous global impact of actin on diverse cellular process…
View article: Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1
Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1 Open
The coordination between actin and microtubule network is crucial, yet our understanding of the underlying mechanisms remains limited. In this study, we used travelling waves in the cell cortex to characterize the collective dynamics of cy…
View article: Unraveling cellular complexity with unlimited multiplexed super-resolution imaging
Unraveling cellular complexity with unlimited multiplexed super-resolution imaging Open
Summary Mapping the intricate spatial relationships between the many different molecules inside a cell is essential to understanding cellular functions in all their complexity. Super-resolution fluorescence microscopy offers the required s…
View article: Comparative Study of Curvature Sensing Mediated by F-BAR and an Intrinsically Disordered Region of FBP17
Comparative Study of Curvature Sensing Mediated by F-BAR and an Intrinsically Disordered Region of FBP17 Open
Membrane curvature has emerged as an intriguing physical principle underlying biological signaling and membrane trafficking. The CIP4/FBP17/Toca-1 F-BAR subfamily is unique in the BAR family because its structurally folded F-BAR domain doe…
View article: Comparative study of curvature sensing mediated by F-BAR domain and an intrinsically disordered region of FBP17
Comparative study of curvature sensing mediated by F-BAR domain and an intrinsically disordered region of FBP17 Open
Membrane curvature has emerged as an intriguing physical organization principle underlying biological signaling and membrane trafficking. FBP17 of the CIP4/FBP17/Toca-1 F-BAR family is unique in the BAR family because its structurally fold…
View article: Collective membrane dynamics emerging from curvature-dependent spatial coupling
Collective membrane dynamics emerging from curvature-dependent spatial coupling Open
Membrane curvature has been recognized as an active participant of fundamental biological processes including vesicular transport and organelle biogenesis, but its effects on membrane remodeling are typically local. Here we show membrane c…