Maolei Gong
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View article: MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway
MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway Open
View article: Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury
Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury Open
Traumatic brain injury (TBI) is an acquired insult to the brain caused by an external mechanical force, potentially resulting in temporary or permanent impairment. Microglia, the resident immune cells of the central nervous system, are act…
View article: Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma
Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma Open
View article: <i>MARK2</i>variants cause autism spectrum disorder<i>via</i>the downregulation of WNT/β-catenin signaling pathway
<i>MARK2</i>variants cause autism spectrum disorder<i>via</i>the downregulation of WNT/β-catenin signaling pathway Open
MARK2 , a member of the evolutionarily conserved PAR1/MARK serine/threonine kinase family, has been identified as a novel risk gene for autism spectrum disorder (ASD) based on the enrichment of de novo loss-of-function (Lof) variants in la…
View article: Abnormal microglial polarization induced by <scp><i>Arid1a</i></scp> deletion leads to neuronal differentiation deficits
Abnormal microglial polarization induced by <span><i>Arid1a</i></span> deletion leads to neuronal differentiation deficits Open
Objective Microglia, the prototypical innate immune cells of the central nervous system (CNS), are highly plastic and assume their phenotypes dependent on intrinsically genetic, epigenetic regulation or extrinsically microenvironmental cue…
View article: Characterization of an Antiviral Component in Human Seminal Plasma
Characterization of an Antiviral Component in Human Seminal Plasma Open
Numerous types of viruses have been found in human semen, which raises concerns about the sexual transmission of these viruses. The overall effect of semen on viral infection and transmission have yet to be fully investigated. In the prese…
View article: Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells
Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells Open
The mumps virus (MuV) causes epidemic parotitis. MuV also frequently infects the testis and induces orchitis, an important etiological factor contributing to male infertility. However, mechanisms underlying MuV infection of the testis rema…
View article: LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p
LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p Open
Previous studies have shown that lncRNA small nuclear RNA host gene 7 (lncRNA SNHG7) played an important role in cancer progression. However, the role of lncRNA SNHG7 in cardiac fibrosis is still poorly understood. In this study, the resul…
View article: Damaged male germ cells induce epididymitis in mice
Damaged male germ cells induce epididymitis in mice Open
Epididymitis can be caused by infectious and noninfectious etiological factors. While microbial infections are responsible for infectious epididymitis, the etiological factors contributing to noninfectious epididymitis remain to be defined…
View article: Mumps virus infection disrupts blood‐testis barrier through the induction of TNF‐α in Sertoli cells
Mumps virus infection disrupts blood‐testis barrier through the induction of TNF‐α in Sertoli cells Open
Mumps virus (MuV) has high tropism to the testis and may lead to male infertility. Sertoli cells are the major targets of MuV infection. However, the mechanisms by which MuV infection impairs male fertility and Sertoli cell function remain…
View article: Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alpha†
Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alpha† Open
Systemic inflammation may impair male fertility, and its underlying mechanisms remain poorly understood. The present study investigates the effect of lipopolysaccharide (LPS)-induced systemic inflammation on the testis and epididymis in mi…
View article: Correction: C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis
Correction: C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis Open
View article: C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis
C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis Open
Mumps virus (MuV) infection usually results in germ cell degeneration in the testis, which is an etiological factor for male infertility. However, the mechanisms by which MuV infection damages male germ cells remain unclear. The present st…
View article: Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication
Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication Open
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not full…