Maolin Ge
YOU?
Author Swipe
View article: Development and validation of a machine learning model for predicting vulnerable carotid plaques using routine blood biomarkers and derived indicators: insights into sex-related risk patterns
Development and validation of a machine learning model for predicting vulnerable carotid plaques using routine blood biomarkers and derived indicators: insights into sex-related risk patterns Open
View article: TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma
TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma Open
Translocation renal cell carcinoma (tRCC) is an aggressive subtype of kidney cancer driven by TFE3 gene fusions, which act via poorly characterized downstream mechanisms. Here we report that TFE3 fusions transcriptionally rewire tRCCs towa…
View article: DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability Open
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To…
View article: NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer Open
View article: NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer Open
View article: NRF2 activation induces NADH-reductive stress providing a metabolic vulnerability in lung cancer
NRF2 activation induces NADH-reductive stress providing a metabolic vulnerability in lung cancer Open
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through mutation of its negative regulator KEAP1. NRF2 has been studied extensively in KEAP1-mutant cancers, however the role of this pathway in cancers…
View article: A T-cell independent universal cellular therapy strategy through antigen depletion
A T-cell independent universal cellular therapy strategy through antigen depletion Open
Rationale: T cell therapeutic strategy using CD19-targeting chimeric antigen receptor (CAR) is a revolutionary, novel, and successful treatment for B-cell malignancies. However, the dependency on T-cell mediated cytotoxicity restric…
View article: A T-cell independent universal cellular therapy strategy through antigen depletion
A T-cell independent universal cellular therapy strategy through antigen depletion Open
CD19-targeting chimeric antigen receptor (CAR) T-cell therapeutics is a revolutionary, novel and successful treatment for B-cell malignancies. However, while CD19-CAR-T therapy can obtain high rates of complete responses in these patients,…
View article: Deubiquitinating enzyme inhibitor alleviates cyclin A1‐mediated proteasome inhibitor tolerance in mixed‐lineage leukemia
Deubiquitinating enzyme inhibitor alleviates cyclin A1‐mediated proteasome inhibitor tolerance in mixed‐lineage leukemia Open
Drug resistance is a significant obstacle to effective cancer treatment. Drug resistance develops from initially reversible drug‐tolerant cancer cells, which offer therapeutic opportunities to impede cancer relapse. The mechanisms of resis…
View article: Deubiquitinating Enzyme Inhibitor Alleviates Cyclin A1-mediated Proteasome Inhibitor Tolerance in Mixed-lineage Leukemia
Deubiquitinating Enzyme Inhibitor Alleviates Cyclin A1-mediated Proteasome Inhibitor Tolerance in Mixed-lineage Leukemia Open
Background: Drug resistance is a significant obstacle to effective cancer treatment. Drug resistance develops from initially reversible drug-tolerant cancer cells, which offers therapeutic opportunities to impede cancer relapse. The mechan…
View article: Modulating proteasome inhibitor tolerance in multiple myeloma: an alternative strategy to reverse inevitable resistance
Modulating proteasome inhibitor tolerance in multiple myeloma: an alternative strategy to reverse inevitable resistance Open
View article: mTORC1‐mediated amino acid signaling is critical for cell fate determination under transplant‐induced stress
mTORC1‐mediated amino acid signaling is critical for cell fate determination under transplant‐induced stress Open
Transplantation of in vitro ‐manipulated cells is widely used in hematology. While transplantation is well recognized to impose severe stress on transplanted cells, the nature of transplant‐induced stress remains elusive. Here, we propose …
View article: Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers
Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers Open
Lung cancer is one of the most common human cancers both in incidence and mortality, with prognosis particularly poor in metastatic cases. Metastasis in lung cancer is a multifarious process driven by a complex regulatory landscape involvi…
View article: Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors
Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors Open
View article: Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia
Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia Open
View article: Exosomes mediate intercellular transfer of non–autonomous tolerance to proteasome inhibitors in mixed‐lineage leukemia
Exosomes mediate intercellular transfer of non–autonomous tolerance to proteasome inhibitors in mixed‐lineage leukemia Open
Proteasome inhibitors significantly improve cancer outcomes, but their use is eventually followed by proteasome inhibitor resistance and relapse. Current understanding of proteasome inhibitor resistance is limited to cell‐autonomous mechan…
View article: Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells
Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells Open
Background Arsenic sulfide was found to have potential anti-cancer activities, especially in gastric cancer. However, the underlying mechanism need to be further explored. This study was aimed to investigate the mechanism of arsenic compou…
View article: MLL is required for miRNA-mediated translational repression
MLL is required for miRNA-mediated translational repression Open
View article: Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia
Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia Open
View article: Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway*
Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway* Open
View article: HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection
HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection Open
Enterovirus 71 (EV71) is an RNA virus that causes hand-foot-mouth disease (HFMD), and even fatal encephalitis in children. Although EV71 pathogenesis remains largely obscure, host immune responses may play important roles in the developmen…