Maolin He
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View article: Looking to the future through data: The rise and potential of gamification in medical education – A bibliometric analysis from 2000 to 2024
Looking to the future through data: The rise and potential of gamification in medical education – A bibliometric analysis from 2000 to 2024 Open
Background: Advancements in educational technology have highlighted the significant potential of gamification in medical education. Herein we employed bibliometric methods to systematically analyze the development pathways and prospects of…
View article: Pan-cancer NK cell-related immunotherapy signatures for predicting PD-1 treatment response
Pan-cancer NK cell-related immunotherapy signatures for predicting PD-1 treatment response Open
Natural killer (NK) cells are an integral component of the tumor microenvironment, and their role in immune checkpoint inhibitors (ICI) therapy has garnered increasing attention. However, comprehensive studies on NK cells across cancers, e…
View article: Identification of core genes in systemic juvenile idiopathic arthritis based on 113 machine learning algorithms
Identification of core genes in systemic juvenile idiopathic arthritis based on 113 machine learning algorithms Open
Background: Systemic juvenile idiopathic arthritis (sJIA) represents the most severe subtype of juvenile idiopathic arthritis and is classified as a rare autoinflammatory disease. It significantly impacts patients’ quality of life. Its pat…
View article: The effect of physical exercise on sleep quality in university students: chain mediation of health literacy and life satisfaction
The effect of physical exercise on sleep quality in university students: chain mediation of health literacy and life satisfaction Open
Objective The present study was designed to explore the relationship between physical exercise and sleep quality. Specifically, it investigates the extent to which this relationship is mediated by a sequential process involving health lite…
View article: Proanthocyanidins delay the senescence of young asparagus stems by regulating antioxidant capacity and synthesis of phytochemicals
Proanthocyanidins delay the senescence of young asparagus stems by regulating antioxidant capacity and synthesis of phytochemicals Open
Asparagus, characterized by its high metabolic rate, is susceptible to quality degradation. Proanthocyanidins have antioxidant, antibacterial, antiviral, and other biological functions and can inhibit the production of reactive oxygen spec…
View article: High GNG4 predicts adverse prognosis for osteosarcoma: Bioinformatics prediction and experimental verification
High GNG4 predicts adverse prognosis for osteosarcoma: Bioinformatics prediction and experimental verification Open
Background Guanine nucleotide binding (G) protein subunit γ 4 (GNG4) is closely related to the malignant progression and poor prognosis of various tumours. However, its role and mechanism in osteosarcoma remain unclear. This study aimed to…
View article: Correction: Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging
Correction: Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging Open
Correction for ‘Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging’ by Yanfeng Ding, et al. , Biomater. Sci ., 2021, 9 , 6236–6250. https://doi.org/10.1039/D1BM00743B.
View article: Complete Chloroplast Genome Sequence of a New Variety of Brasenia schreberi: Genome Characteristics, Comparative Analysis, and Phylogenetic Relationships
Complete Chloroplast Genome Sequence of a New Variety of Brasenia schreberi: Genome Characteristics, Comparative Analysis, and Phylogenetic Relationships Open
This study sequenced and assembled the chloroplast (cp) genome of Brasenia schreberi cv. ‘Mahu Chuncai’, a novel variety of B. schreberi rich in nutrients with distinctive characteristics, unlike other varieties in China. The cpDNA genome …
View article: Variation in the main health-promoting compounds and antioxidant activity of different organs of Wasabi (Eutrema japonicum) from two producing areas
Variation in the main health-promoting compounds and antioxidant activity of different organs of Wasabi (Eutrema japonicum) from two producing areas Open
Wasabi (Eutrema japonicum ), also known as Japanese horseradish, is a perennial herb widely used in Japanese cuisine for its special flavour. The health-promoting phytochemicals and antioxidant capacity of four organs (leaf, petiole, rhizo…
View article: Effects of Exogenous Phthalic Acid on Seed Germination, Root Physiological Characteristics, and Mineral Element Absorption of Watermelon
Effects of Exogenous Phthalic Acid on Seed Germination, Root Physiological Characteristics, and Mineral Element Absorption of Watermelon Open
To understand the effect of exogenous PA on the watermelon root system, the watermelon variety ‘Zaojia 84–24’ was used as experimental material. This study investigated the effects of allelochemicals DIBP and DOP at varying different conce…
View article: Implantable Polyacrylonitrile-Spermidine Electrospun Nanofibers with Sustainable ROS Scavening Capacity for Osteoarthritis (OA) Therapy
Implantable Polyacrylonitrile-Spermidine Electrospun Nanofibers with Sustainable ROS Scavening Capacity for Osteoarthritis (OA) Therapy Open
Osteoarthritis (OA) is a major cause of mobility impairment in the elderly. Scavenging excessive reactive oxygen species (ROS) to inhibit oxidative stress damage is a theraupetic strategy for OA. However, low clearance efficiency, rapid cl…
View article: RPL34 regulates osteosarcoma cells proliferation through c-Myc/RPL34 signaling axis
RPL34 regulates osteosarcoma cells proliferation through c-Myc/RPL34 signaling axis Open
Background Ribosomal protein L34 (RPL34) is a member of the L34E ribosomal protein family containing zinc finger domains. This protein plays a key role in regulating the apoptosis, cell cycle progression and proliferation of various cancer…
View article: Transcriptome Profiling Reveals the Effects of Nitric Oxide on the Growth and Physiological Characteristics of Watermelon under Aluminum Stress
Transcriptome Profiling Reveals the Effects of Nitric Oxide on the Growth and Physiological Characteristics of Watermelon under Aluminum Stress Open
Excessive aluminum ions (Al3+) in acidic soil can have a toxic effect on watermelons, restricting plant growth and reducing yield and quality. In this study, we found that exogenous application of nitric oxide (NO) could increase the photo…
View article: Clinical Significance And Potential Mechanisms of The RNA Methyltransferase KIAA1429 In Osteosarcoma
Clinical Significance And Potential Mechanisms of The RNA Methyltransferase KIAA1429 In Osteosarcoma Open
Background: KIAA1429, a member of the RNA methyltransferase complex, is involved in cancer progression. However, the clinical significance of KIAA1429 in osteosarcoma (OS) and the underlying mechanisms by which it contributes to disease pr…
View article: Function and Potential Molecular Mechanism of High STIL Expression in Osteosarcoma
Function and Potential Molecular Mechanism of High STIL Expression in Osteosarcoma Open
BackgroundSCL/TAL1 interrupting locus (STIL) is associated with the progression of several tumors; however, the biological role of STIL in osteosarcoma remains poorly understood.MethodsIn this study, the clinical significance of STIL in os…
View article: Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing
Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing Open
The underlying molecular mechanisms of intervertebral disc degeneration (IDD) remain unclear. This study aimed to identify the crucial molecules and explore the function of noncoding RNAs and related pathways in IDD. We randomly selected t…
View article: Supplementary Material for: Topotecan plus Platinum-Based Chemotherapy versus Etoposide plus Platinum-Based Chemotherapy for Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Supplementary Material for: Topotecan plus Platinum-Based Chemotherapy versus Etoposide plus Platinum-Based Chemotherapy for Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background: Whether topotecan plus platinum-based chemotherapy (TP) can achieve better results than etoposide plus platinum-based chemotherapy (EP) for small-cell lung cancer (SCLC) treatment is still controversial in clinical applications…
View article: Neuroprotective Effects of Higenamine Against the Alzheimer’s Disease Via Amelioration of Cognitive Impairment, A<b>β</b> Burden, Apoptosis and Regulation of Akt/GSK3β Signaling Pathway
Neuroprotective Effects of Higenamine Against the Alzheimer’s Disease Via Amelioration of Cognitive Impairment, A<b>β</b> Burden, Apoptosis and Regulation of Akt/GSK3β Signaling Pathway Open
The present investigation was envisaged to elucidate the neuroprotective effect of Higenamine (HGN) against aluminum chloride (AlCl 3 ) triggered experimental Alzheimer’s disease (AD) rat model. Thirty-six male albino Wister rats were rand…
View article: [Application of pasteurized tumor-bearing bone replantation for primary malignant bone tumor of extremities].
[Application of pasteurized tumor-bearing bone replantation for primary malignant bone tumor of extremities]. Open
The procedure of the pasteurized tumor-bearing bone replantation is an effective, simple, and economic way in repair of massive segmental bone defect to save limb function for primary malignant bone tumor of extremities.
View article: Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway
Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway Open
Knockdown of RPL34 suppresses osteosarcoma cells proliferation probably through EIF3A, EIF3F, and FAU.
View article: Carotid artery plaque intervention with Tongxinluo capsule (CAPITAL): A multicenter randomized double-blind parallel-group placebo-controlled study
Carotid artery plaque intervention with Tongxinluo capsule (CAPITAL): A multicenter randomized double-blind parallel-group placebo-controlled study Open
To determine whether the traditional Chinese medicine Tongxinluo (TXL) is efficacious at retarding the progression of carotid atherosclerotic lesions, a total of 1,212 patients with a focal intima-media thickness (IMT) of ≥1.2 mm of the ca…
View article: Targeting of <scp>CDKN</scp>1B by miR‐222‐3p may contribute to the development of intervertebral disc degeneration
Targeting of <span>CDKN</span>1B by miR‐222‐3p may contribute to the development of intervertebral disc degeneration Open
Micro RNA s (mi RNA s) are small endogenous non‐coding RNA s that can negatively regulate the expression of their complementary mRNA targets, and have been implicated in various pathophysiological processes. In this study, we examined the …