Mingzi Ran
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View article: Effect of pre-incisional infiltration with bupivacaine liposome for postoperative pain in patients undergoing acoustic neuroma surgery: study protocol for a prospective, double-blind, randomized controlled study
Effect of pre-incisional infiltration with bupivacaine liposome for postoperative pain in patients undergoing acoustic neuroma surgery: study protocol for a prospective, double-blind, randomized controlled study Open
Background Post-craniotomy pain, relatively common in neurosurgery, is often inadequately managed. Preincisional infiltration with ropivacaine provides effective analgesia for post-craniotomy pain, although its duration of action is limite…
View article: Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine
Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine Open
While N-methyl-d-aspartate receptor (NMDAR) blockade is crucial for the rapid antidepressant effects of ketamine, the involvement of other mechanisms remains contentious, particularly regarding the role of serotonin, a key neurotransmitter…
View article: The value of pupillary diameter in evaluating pain perception after awakening in patients undergoing general anesthesia during orthopedic surgery
The value of pupillary diameter in evaluating pain perception after awakening in patients undergoing general anesthesia during orthopedic surgery Open
Background The pupillary response to tetanic electrical stimulation reflects the balance between nociceptive stimulation and analgesia. Although pupillary pain index (PPI) was utilized to predict postoperative pain, it depended on tetanic …
View article: The value of pupillary diameter in evaluating pain perception after awakening in patients undergoing general anesthesia during orthopedic surgery
The value of pupillary diameter in evaluating pain perception after awakening in patients undergoing general anesthesia during orthopedic surgery Open
Background The pupillary response to tetanic electrical stimulation has been used to reflect the balance between nociceptive stimuli and analgesia. Although pupillary pain index (PPI) was utilized to predict postoperative pain, it depends …
View article: The modified lymphocyte C-reactive protein score is a promising indicator for predicting 3-year mortality in elderly patients with intertrochanteric fractures
The modified lymphocyte C-reactive protein score is a promising indicator for predicting 3-year mortality in elderly patients with intertrochanteric fractures Open
Background Hip fractures are common in elderly patients, and almost all the patients undergo surgery. This study aimed to develop a novel modified lymphocyte C-reactive protein (CRP) score (mLCS) to simply and conveniently predict 3-year m…
View article: Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Attenuates Surgical Wound-Induced Blood-Brain Barrier Dysfunction in Mice
Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Attenuates Surgical Wound-Induced Blood-Brain Barrier Dysfunction in Mice Open
Blood-brain barrier (BBB) is the most important component of central nervous system (CNS) to keep toxins and pathogens from CNS. Although our studies demonstrated that using interleukin-6 antibodies (IL-6-AB) reversed the increased permeab…
View article: Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis
Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis Open
Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and …
View article: The Modified Lymphocyte C-reactive Protein Score is a Promising Indicator for Predicting 3-year Mortality in Elderly Patients with Intertrochanteric Fractures
The Modified Lymphocyte C-reactive Protein Score is a Promising Indicator for Predicting 3-year Mortality in Elderly Patients with Intertrochanteric Fractures Open
Background Hip fractures are common in elderly patients, and almost all the patients undergo surgery. This study aimed to develop a novel modified lymphocyte C-reactive protein (CRP) score (mLCS) to simply and conveniently predict 3-year m…
View article: New insight into neurological degeneration: Inflammatory cytokines and blood–brain barrier
New insight into neurological degeneration: Inflammatory cytokines and blood–brain barrier Open
Neurological degeneration after neuroinflammation, such as that resulting from Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), and post-traumatic brain injury (TBI), is typically associated with high mortality and morbidity and …
View article: Epidemiology and clinical characteristics of burns in mainland China from 2009 to 2018
Epidemiology and clinical characteristics of burns in mainland China from 2009 to 2018 Open
Background Burn injuries place a heavy burden on the global healthcare system. However, there is still a lack of nationwide studies on the epidemiological characteristics of burn patients in mainland China. The present study aims to accura…
View article: Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia
Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia Open
Aims General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highl…
View article: Serotonergic neurons in the dorsal raphe nucleus mediate the arousal-promoting effect of orexin during isoflurane anesthesia in male rats
Serotonergic neurons in the dorsal raphe nucleus mediate the arousal-promoting effect of orexin during isoflurane anesthesia in male rats Open
Previous studies have demonstrated that the activation of orexinergic neurons facilitates the recovery of animals from general anesthesia. Moreover, serotonergic neurons that receive projections from orexin neurons have also been shown to …
View article: Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation Open
The lateral habenula has been widely studied for its contribution in generating reward-related behaviors [1, 2]. We have found that this nucleus plays an unexpected role in the sedative actions of the general anesthetic propofol. The later…
View article: Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats
Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats Open
Circadian rhythm (CR) plays a critical role in the treatment of several diseases. However, the role of CR in the treatment of peripheral nerve defects has not been studied. It is also known that the pulsed electromagnetic fields (PEMF) can…