Maonan Wang
YOU?
Author Swipe
View article: Over-Expression of TNFRSF12A Promotes Immune Suppression and Facilitates Angiogenesis in Triple-Negative Breast Cancer
Over-Expression of TNFRSF12A Promotes Immune Suppression and Facilitates Angiogenesis in Triple-Negative Breast Cancer Open
The urgent need for novel therapeutic strategies in triple-negative breast cancer (TNBC)—characterized by absent ER, PR, and HER2 expression—stems from its association with a paucity of effective treatments and an adverse prognosis. This s…
View article: TNFRSF12A Drives Triple-Negative Breast Cancer Progression via Immune Microenvironment Reprogramming and Facilitated Angiogenesis
TNFRSF12A Drives Triple-Negative Breast Cancer Progression via Immune Microenvironment Reprogramming and Facilitated Angiogenesis Open
The urgent need for novel therapeutic strategies in triple-negative breast cancer (TNBC)—characterized by absent ER, PR, and HER2 expression—stems from its association with a paucity of effective treatments and an adverse prognosis. This s…
View article: ITM2A as a potential prognostic marker for triple-negative breast cancer
ITM2A as a potential prognostic marker for triple-negative breast cancer Open
Different subtypes of breast cancer pose great challenges for precision therapy, especially triple-negative breast cancer (TNBC), because it lacks effective therapeutic targets and is highly resistant to chemotherapy. In this study, the tr…
View article: Characterization of Cuproptosis-Related LncRNAs Prognostic Signature and Identification of LINC02285 as a Novel Biomarker for Ovarian Cancer
Characterization of Cuproptosis-Related LncRNAs Prognostic Signature and Identification of LINC02285 as a Novel Biomarker for Ovarian Cancer Open
Our study established a prognostic model based on 4 CRLs to assess overall survival and the immune microenvironment in OC patients. As a high-risk factor, LINC02285 demonstrates potential as a prognostic biomarker for OC.
View article: Malignant features related PRDX1 associated with osimertinib sensitivity of EGFR-mutant lung adenocarcinoma
Malignant features related PRDX1 associated with osimertinib sensitivity of EGFR-mutant lung adenocarcinoma Open
The peroxiredoxin (PRDX) family, also known as the peroxidase family, consists of six members that participate in a variety of essential bio-processes in carcinogenesis. However, their molecular role in lung adenocarcinoma (LUAD) has not b…
View article: Metabolic reprogramming in cancer and senescence
Metabolic reprogramming in cancer and senescence Open
The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being the aging of the global population. Statistical data show that cancer incidence and mortality rates show a clear upward trend with age…
View article: Epigenetic editing of <i>BRCA1</i> promoter increases cisplatin and olaparib sensitivity of ovarian cancer cells
Epigenetic editing of <i>BRCA1</i> promoter increases cisplatin and olaparib sensitivity of ovarian cancer cells Open
Drug resistance is the primary contributor to the high mortality rate of ovarian cancer (OC). The loss of BRCA1/2 function is linked to drug sensitivity in OC cells. The aim of this study is to enhance the drug sensitivity of OC cells by i…
View article: Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis
Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis Open
Background: Ovarian cancer has a poor prognosis, and DNA damage-response (DDR) genes are associated with both its occurrence and prognosis. However, previous studies have mostly focused on genetic mutations, with no clear conclusions on ep…
View article: Reduced Viral Shedding Time in High-Risk COVID-19 Patients Infected by Omicron and Treated with Paxlovid: A Real-World Study from China
Reduced Viral Shedding Time in High-Risk COVID-19 Patients Infected by Omicron and Treated with Paxlovid: A Real-World Study from China Open
The CT value of the Paxlovid therapy group became negative more quickly. This finding suggests that Paxlovid treatment after early diagnosis of the Omicron variant may achieve good therapeutic efficacy.
View article: Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer
Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer Open
Our study suggests that targeting TFAP2A may provide a novel and effective strategy for cancer treatment.
View article: White light powered antimicrobial nanoagents for triple photothermal, chemodynamic and photodynamic based sterilization
White light powered antimicrobial nanoagents for triple photothermal, chemodynamic and photodynamic based sterilization Open
State of the art antibacterial nanoagents made more biocompatible and cost-effective with multiple modalities.
View article: Oridonin attenuates dextran sulfate sodium‑induced ulcerative colitis in mice via the Sirt1/NF‑κB/p53 pathway
Oridonin attenuates dextran sulfate sodium‑induced ulcerative colitis in mice via the Sirt1/NF‑κB/p53 pathway Open
Ulcerative colitis (UC) is a serious chronic inflammatory bowel disease. Oridonin (Ori) has anti‑inflammatory, antibacterial and antitumor activities. The current study aimed to investigate the regulatory role of Ori in UC. BALB/C mice wer…
View article: Research on Influencing Factors of Offline Fresh E-commerce Sales Intention Under the Background of Digital Economy
Research on Influencing Factors of Offline Fresh E-commerce Sales Intention Under the Background of Digital Economy Open
Under the background of digital economy, China's industries and Internet industries have also been further integrated. The e-commerce industry has achieved leapfrog development, and the proportion of agricultural products in e-commerce sal…
View article: The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway
The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway Open
BackgroundLong noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved in several pathological responses. However, many important lncRNAs in breast cancer have not been identified and their exp…
View article: The regulatory networks of the Hippo signaling pathway in cancer development
The regulatory networks of the Hippo signaling pathway in cancer development Open
The Hippo signaling pathway is a relatively young tumor-related signaling pathway. Although it was discovered lately, research on it developed rapidly. The Hippo signaling pathway is closely relevant to the occurrence and development of tu…
View article: LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma
LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma Open
Long noncoding RNA (lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels have often been associated with cancer pathogenesis. In this study, we identified AA…
View article: Bio responsive self-assembly of Au-miRNAs for targeted cancer theranostics
Bio responsive self-assembly of Au-miRNAs for targeted cancer theranostics Open
National Natural Science Foundation of China (91753106); Primary Research & Development Plan of Jiangsu Province (BE2019716); National Key Research and Development Program of China (2017YFA0205300).
View article: In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition
In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition Open
Significance Although many efforts have been devoted to localize and monitor cancer progression, it is still difficult to precisely evaluate the development of cancers for efficient targeted treatments. Herein, we demonstrate a straightfor…
View article: Role of tumor microenvironment in tumorigenesis
Role of tumor microenvironment in tumorigenesis Open
Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenviro…
View article: Roles of miR-186 and PTTG1 in colorectal neuroendocrine tumors.
Roles of miR-186 and PTTG1 in colorectal neuroendocrine tumors. Open
PTTG1 expression was significantly up-regulated in patients with CNET, which was induced by the down-regulated miR-186. MiR-186 may participate in the regulation of infiltration and invasion in CNET patients through targeting PTTG1 express…