Mei Yang
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View article: RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability
RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability Open
RNA-binding proteins (RBPs) critically regulate post-transcriptional gene expression, yet their roles in chemotherapy resistance remain underexplored. Here, through a targeted siRNA screen of 40 RBM family members, we identified RNA-bindin…
View article: STAMBP Accelerates Progression and Tamoxifen Resistance of Breast Cancer Through Deubiquitinating ERα
STAMBP Accelerates Progression and Tamoxifen Resistance of Breast Cancer Through Deubiquitinating ERα Open
Breast cancer (BRCA) remains a global health burden, with endocrine-resistant ER-positive BRCA posing therapeutic challenges. This study investigates STAMBP’s role in breast cancer progression and evaluates its potential as a therapeutic t…
View article: Superior Current Spreading in InGaN Green Micro-LEDs Achieved by Hexagonal Mesa Engineering
Superior Current Spreading in InGaN Green Micro-LEDs Achieved by Hexagonal Mesa Engineering Open
To address the challenge of low external quantum efficiency (EQE) in green micro-light-emitting diodes (micro-LEDs), we systematically investigated the effects of circular, square, and hexagonal mesa geometries. Through comprehensive fabri…
View article: Multi-Scale Feature Analysis Method for Soil Heavy Metal Based on Two-Dimensional Empirical Mode Decomposition: An Example of Arsenic
Multi-Scale Feature Analysis Method for Soil Heavy Metal Based on Two-Dimensional Empirical Mode Decomposition: An Example of Arsenic Open
The spatial distribution of soil heavy metals was influenced by both natural and anthropogenic factors, and the multi-scale characteristics of heavy metals played a key role in analyzing their influencing factors. Taking arsenic (As) of an…
View article: Improving Winter Wheat Yield Estimation Under Saline Stress by Integrating Sentinel-2 and Soil Salt Content Using Random Forest
Improving Winter Wheat Yield Estimation Under Saline Stress by Integrating Sentinel-2 and Soil Salt Content Using Random Forest Open
Accurate estimation of winter wheat yield under saline stress is crucial for addressing food security challenges and optimizing agricultural management in regional soils. This study proposed a method integrating Sentinel-2 data and field-m…
View article: Specificity protein 1 initiates epithelial-mesenchymal transition of circulating tumor cells to inhibit metastasis in prostate cancer
Specificity protein 1 initiates epithelial-mesenchymal transition of circulating tumor cells to inhibit metastasis in prostate cancer Open
Circulating tumor cells (CTCs), as seeds for metastasis, hold great promise for cancer diagnosis, prognosis, and treatment. Based on the expression of biomarkers, CTCs can be categorized as epithelial (E), mesenchymal (M), or hybrid (M/E) …
View article: Exogenous adenosine counteracts tigecycline resistance in <i>tet</i> (X3)-harboring <i>Escherichia coli</i>
Exogenous adenosine counteracts tigecycline resistance in <i>tet</i> (X3)-harboring <i>Escherichia coli</i> Open
The rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet (X3) gene conferring high-level tigecycline resistance is deeply concerning.…
View article: Preparation, structural characterization, and performance evaluation of antler plate collagen peptide-calcium chelates
Preparation, structural characterization, and performance evaluation of antler plate collagen peptide-calcium chelates Open
This study investigated the preparation conditions, stability, calcium absorption characteristics, anti-osteoporotic activity, and chelation properties of antler plate collagen peptide‑calcium chelates (APCP-Ca). The high-affinity calcium …
View article: Ptbp1 Knockdown in Glial Cells Promotes Motor and Sensory Function Recovery After Peripheral Nerve Injury
Ptbp1 Knockdown in Glial Cells Promotes Motor and Sensory Function Recovery After Peripheral Nerve Injury Open
Background: Peripheral nerve injury (PNI) frequently causes persistent sensory and motor deficits with limited therapeutic options. While Ptbp1‐mediated astrocyte reprogramming shows promise in central nervous system repair, its role in PN…
View article: Engineered <scp>EVs</scp>‐Mediated <scp>miR</scp>‐222 Targeting <scp>PTEN</scp>/<scp>FN1</scp> Axis Reverses Anthracycline Resistance in <scp>HER2</scp>‐Negative Breast Cancer
Engineered <span>EVs</span>‐Mediated <span>miR</span>‐222 Targeting <span>PTEN</span>/<span>FN1</span> Axis Reverses Anthracycline Resistance in <span>HER2</span>‐Negative Breast Cancer Open
Anthracycline resistance represents a critical therapeutic challenge in breast cancer treatment, wherein alterations in the tumor immune microenvironment and enhanced cellular resistance mechanisms facilitate chemoresistance progression. T…
View article: Single‐cell sequencing reveals the role of <i>IL‐33</i><sup>+</sup> endothelial subsets in promoting early gastric cancer progression
Single‐cell sequencing reveals the role of <i>IL‐33</i><sup>+</sup> endothelial subsets in promoting early gastric cancer progression Open
Early gastric cancer (EGC) represents a critical stage in preventing and controlling the progression from gastritis to advanced gastric cancer (AGC). Therefore, identifying the single‐cell characteristics of EGC, particularly the cellular …
View article: M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation
M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation Open
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects various organs and systems, significantly impacting patients' health and quality of life. Conventional drugs, including glucocorticoids and standard immunosup…
View article: Carboxyamidotriazole Regulates the Function of Salivary Gland Epithelial Cells and B Cells to Alleviate Experimental Sjögren′s Disease in Mice
Carboxyamidotriazole Regulates the Function of Salivary Gland Epithelial Cells and B Cells to Alleviate Experimental Sjögren′s Disease in Mice Open
Sjögren's disease (SjD), a systemic autoimmune disease, suffers from restricted treatment choices. The activation of salivary gland epithelial cells and abnormal auto-reactive B cells, triggering cytokine and autoantibody generation, is ke…
View article: Baicalin restores innate lymphoid immune imbalance during exacerbation of COPD
Baicalin restores innate lymphoid immune imbalance during exacerbation of COPD Open
Chronic obstructive pulmonary disease (COPD) is characterized by immune dysregulation, including altered innate lymphoid cell (ILC) immune responses, particularly during exacerbations (ECOPD). Baicalin, a natural compound prevalent in vari…
View article: Endoscopists and endoscopic assistants’ qualifications, but not their biopsy rates, improve gastric precancerous lesions detection rate
Endoscopists and endoscopic assistants’ qualifications, but not their biopsy rates, improve gastric precancerous lesions detection rate Open
BACKGROUND Detecting gastric precancerous lesions (GPLs) is critical for the early diagnosis and treatment of gastric cancer. Endoscopy combined with tissue examination is an important method for detecting GPLs. However, negative biopsy re…
View article: Organ-based characterization of B cells in patients with systemic lupus erythematosus
Organ-based characterization of B cells in patients with systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical mana…
View article: Leptin increases chemosensitivity by inhibiting CPT1B in colorectal cancer cells
Leptin increases chemosensitivity by inhibiting CPT1B in colorectal cancer cells Open
These findings indicate that leptin, through modulation of CPT1B, may serve as a promising adjunct to chemotherapy for CRC, addressing the challenge of chemoresistance and improving therapeutic outcomes. The leptin-CPT1B axis may be potent…
View article: Effectiveness of a home-based, post-discharge early intervention program for very preterm infants in reducing parental stress: a randomized controlled trial
Effectiveness of a home-based, post-discharge early intervention program for very preterm infants in reducing parental stress: a randomized controlled trial Open
This study was registered in the Chinese Clinical Trial Registry (registration number: CTR1900028330). Registration date: December 19, 2019.
View article: Hyperglycemia‐induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis
Hyperglycemia‐induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis Open
Background Hyperglycemia‐induced neuroinflammation significantly contributes to diabetic neuropathic pain (DNP), but the underlying mechanisms remain unclear. Objective To investigate the role of Sirt3, a mitochondrial deacetylase, in hype…
View article: Effects of the fermentation quality and microbial community of waxy maize mixed with fodder soybean silage
Effects of the fermentation quality and microbial community of waxy maize mixed with fodder soybean silage Open
Waxy maize ( Zea mays L. sinensis Kulesh) is highly regarded for its high nutritional content and unique taste. Although the stalks and leaves contain high carbohydrate levels after ear harvesting, inadequate crude protein (CP) limits the …
View article: HSV-1 reactivation results in post-herpetic neuralgia by upregulating Prmt6 and inhibiting cGAS-STING
HSV-1 reactivation results in post-herpetic neuralgia by upregulating Prmt6 and inhibiting cGAS-STING Open
Chronic varicella zoster virus (VZV) infection induced neuroinflammatory condition is the critical pathology of post-herpetic neuralgia (PHN). The immune escape mechanism of VZV remains elusive. As to mice have no VZV infection receptor, h…
View article: MicroRNA expression profiles of stress susceptibility and resilience in the prelimbic and infralimbic cortex of rats after single prolonged stress
MicroRNA expression profiles of stress susceptibility and resilience in the prelimbic and infralimbic cortex of rats after single prolonged stress Open
The experience of traumatic stress can engender lasting memories associated with the trauma, often resulting in post-traumatic stress disorder (PTSD). However, only a minority of individuals develop PTSD symptoms upon exposure. The neurobi…
View article: Lyn‐mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating <scp>IRF5</scp> nuclear translocation in spinal dorsal horn
Lyn‐mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating <span>IRF5</span> nuclear translocation in spinal dorsal horn Open
The pro‐inflammatory phenotype of microglia usually induces neuroinflammatory reactions in neuropathic pain. Glycometabolism shift to glycolysis can promote the pro‐inflammatory phenotype transition of microglia. The omics data analysis su…
View article: Improvement of Lignocellulolytic Enzyme Production Mediated by Calcium Signaling in Bacillus subtilis Z2 under Graphene Oxide Stress
Improvement of Lignocellulolytic Enzyme Production Mediated by Calcium Signaling in Bacillus subtilis Z2 under Graphene Oxide Stress Open
To effectively convert lignocellulose into fermentable sugars, high lignocellulolytic enzyme loading is needed. Graphene oxide (GO) has been shown to promote exoenzyme (lignocellulolytic enzyme, amylase, peptidase, and protease) production…
View article: Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis
Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis Open
Background Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to relieve neuropathi…
View article: Low-Stiffness Hydrogels Promote Peripheral Nerve Regeneration Through the Rapid Release of Exosomes
Low-Stiffness Hydrogels Promote Peripheral Nerve Regeneration Through the Rapid Release of Exosomes Open
A hydrogel system loaded with mesenchymal stem cell–derived exosome (MSC-Exos) is an attractive new tool for tissue regeneration. However, the effect of the stiffness of exosome-loaded hydrogels on tissue regeneration is unclear. Here, the…