Maoying Zhang
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View article: Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis
Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis Open
Introduction Cryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplina…
View article: Precision Treatment of Cryptogenic Brain Abscesses: Metagenomic Next-generation Sequencing and Imaging for Recurrence Control
Precision Treatment of Cryptogenic Brain Abscesses: Metagenomic Next-generation Sequencing and Imaging for Recurrence Control Open
Combined multimodal imaging and mNGS serve as the core modalities for early diagnosis of cryptogenic brain abscesses. Surgical resection significantly improves cure rates and reduces recurrence risk, particularly suitable for patients with…
View article: Conversion of human glial cells into neurons in ex vivo culture of human brain tissue: essential roles of the transcription factors NeuroD1 and Ascl1
Conversion of human glial cells into neurons in ex vivo culture of human brain tissue: essential roles of the transcription factors NeuroD1 and Ascl1 Open
Transcription factor–mediated cell conversion has been reported in the central nervous system of both rodents and nonhuman primates. In particular, glia-to-neuron conversion has been achieved in the brain and spinal cord of animal models f…
View article: Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma
Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma Open
Glioblastoma is the most common malignant tumor in the central nervous system and its occurrence and development is involved in various molecular abnormalities. C-X-C chemokine ligand 10 (CXCL10), an inflammatory chemokine, has been report…
View article: Case Report:The Combination of Surgical and Pharmacological Treatment for Basal Ganglia Cryptococcal Meningitis
Case Report:The Combination of Surgical and Pharmacological Treatment for Basal Ganglia Cryptococcal Meningitis Open
Objective To summarize the clinical presentation, diagnosis, and therapy of cryptococcal meningitis (CM) individuals. Methods Broad literature research has been conducted as well as the author’s own clinical experienced has been reviewed. …
View article: Effect of low-dose bevacizumab on health-related quality of life in patients with recurrent high-grade glioma: A retrospective clinical study
Effect of low-dose bevacizumab on health-related quality of life in patients with recurrent high-grade glioma: A retrospective clinical study Open
View article: Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality
Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality Open
Epoxyeicosatrienoic acids with anti-inflammatory effects are inactivated by soluble epoxide hydrolase (sEH). Both sEH and histone deacetylase 6 (HDAC6) inhibitors are being developed as neuropathic pain relieving agents. Based on the struc…
View article: NeuroD1 and Ascl1 Convert Human Glial Cells into Neurons in Ex Vivo Culture of Human Brain Tissue
NeuroD1 and Ascl1 Convert Human Glial Cells into Neurons in Ex Vivo Culture of Human Brain Tissue Open
Transcription factor-mediated cell conversion has been reported in the central nervous system (CNS) of both rodents and non-human primates (NHPs). In particular, glia-to-neuron (GtN) conversion has been achieved in the brains and spinal co…
View article: Discovery of Dual Lysine Methyltransferase G9a and EZH2 Inhibitors with In Vivo Efficacy against Malignant Rhabdoid Tumor
Discovery of Dual Lysine Methyltransferase G9a and EZH2 Inhibitors with In Vivo Efficacy against Malignant Rhabdoid Tumor Open
In recent years, it has been proposed that G9a/EZH2 dual inhibition is a promising cancer treatment strategy. Herein, we present the discovery of G9a/EZH2 dual inhibitors that merge the pharmacophores of G9a and EZH2 inhibitors. Among them…
View article: Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases
Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases Open
Soluble epoxide hydrolase (sEH) has been identified as an attractive target for anti-inflammatory drug design in recent years. Picomolar level compound G1 against sEH was obtained by introducing the hydrophilic group homopiperazine …
View article: Neurod1 and Ascl1 Convert Human Astrocytes into Neurons in Ex Vivo Culture of Human Brain Tissue
Neurod1 and Ascl1 Convert Human Astrocytes into Neurons in Ex Vivo Culture of Human Brain Tissue Open
View article: Surgical Treatment of Intracranial Solitary Fibroma Tumors
Surgical Treatment of Intracranial Solitary Fibroma Tumors Open
Objective: To summarize the clinical presentation, diagnosis, and therapy of solitary fibrous tumors (SFT) individuals. Methods: Broad literature research has been conducted as well as the author’s own clinical experienced has been reviewe…
View article: Protection of Personal Information in Government Information Disclosure Based on the Administrative Regulation Perspective
Protection of Personal Information in Government Information Disclosure Based on the Administrative Regulation Perspective Open
Personal information protection is the focus of data security governance, while government information disclosure is a practical need for government administration in the context of the information age. As a public authority, the governmen…
View article: Open biopsy with posterior instrumentation followed by anterolateral approach for removal of an uncommon tumor in the cervical spine
Open biopsy with posterior instrumentation followed by anterolateral approach for removal of an uncommon tumor in the cervical spine Open
The conventional treatment for the resection of cervical spinal tumors comprises anterior, posterior, and combined surgical approaches. However, these approaches have certain limitations when tumors invade the vertebrae, vertebral artery, …
View article: Acute Spinal Subarachnoid Hemorrhage: Case Report Cured by Continuous Cerebrospinal Fluid Drainage by Lumbar Puncture
Acute Spinal Subarachnoid Hemorrhage: Case Report Cured by Continuous Cerebrospinal Fluid Drainage by Lumbar Puncture Open
Background: Spinal subarachnoid hemorrhage (SSH) is a rare condition that can lead to severe neurological deficits. Clinicians should consider SSH when neurological deficits such as low back pain, pain hyperalgesia, paraplegia, and urinary…
View article: Forensic identification of traumatic thoracic aortic pseudoaneurysm: A surviving case report
Forensic identification of traumatic thoracic aortic pseudoaneurysm: A surviving case report Open
Traumatic thoracic aortic pseudoaneurysm is a rare and has a high mortality rate. Forensic identification in a living individual is even more rare. We herein present the case involving a 25-year-old male who developed a thoracic aortic pse…
View article: Specific protein 1 depletion attenuates glucose uptake and proliferation of human glioma cells by regulating GLUT3 expression
Specific protein 1 depletion attenuates glucose uptake and proliferation of human glioma cells by regulating GLUT3 expression Open
It has been reported previously that the expression of glucose transporter member 3 (GLUT3) is increased in malignant glioma cells compared with normal glial cells. However, the regulating mechanism that causes this phenomenon remains unkn…
View article: Behavior tests, MRI and MRS and neuron protection mechanism analysis of MCAO rats treated with iNSCs.
Behavior tests, MRI and MRS and neuron protection mechanism analysis of MCAO rats treated with iNSCs. Open
(A) mNSS test of MCAO rats that received PBS(n = 12) or NSCs (n = 12) or iNSC1 (n = 12) treatment post MCAO surgery. NSCs or iNSCs treatment was significantly less mNSS score than PBS treatment on days 7, 10, 14 after transplantation (p <0…
View article: Transdifferentiation-Induced Neural Stem Cells Promote Recovery of Middle Cerebral Artery Stroke Rats
Transdifferentiation-Induced Neural Stem Cells Promote Recovery of Middle Cerebral Artery Stroke Rats Open
Induced neural stem cells (iNSCs) can be directly transdifferentiated from somatic cells. One potential clinical application of the iNSCs is for nerve regeneration. However, it is unknown whether iNSCs function in disease models. We produc…