Mingfeng Xia
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View article: Characterizing the role of RSD-6 in the biogenesis of virus-derived small interfering RNAs and the modulation of viral pathogenesis
Characterizing the role of RSD-6 in the biogenesis of virus-derived small interfering RNAs and the modulation of viral pathogenesis Open
Small interfering RNAs (siRNAs) produced through the processing of viral double-stranded RNAs mediate potent antiviral RNA interference (RNAi) in eukaryotes. In Caenorhabditis elegans , such an antiviral defense is further amplified throug…
View article: Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation
Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation Open
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among indivi…
View article: Inflammatory cytokine regulation and behavioral improvement in depressed mice: The role of photobiomodulation
Inflammatory cytokine regulation and behavioral improvement in depressed mice: The role of photobiomodulation Open
In recent years, depression has emerged as a significant global health concern, prompting many individuals to seek pharmacological interventions. The identification of inflammatory changes in the hippocampus of depressed patients has highl…
View article: Assessment of SREBP Activation Using a Microsomal Vesicle Budding Assay
Assessment of SREBP Activation Using a Microsomal Vesicle Budding Assay Open
Sterol regulatory element binding proteins (SREBPs) are transcription factors that reside in the endoplasmic reticulum (ER) membrane as inactive precursors. To be active, SREBPs are translocated to the Golgi where the transcriptionally act…
View article: Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells
Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells Open
Vascular inflammation is a common pathological basis underlying many cardiovascular diseases. As such, the treatment of vascular inflammation has attracted increasing attention. The Piezo1 pathway has long been shown to play an important r…
View article: Decision: Updates of precision medicine in type 2 diabetes — R1/PR10
Decision: Updates of precision medicine in type 2 diabetes — R1/PR10 Open
Diabetes mellitus is prevalent worldwide and affects 1 in 10 adults. Despite the successful development of glucose-lowering drugs, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 inhibitors rece…
View article: Recommendation: Updates of precision medicine in type 2 diabetes — R1/PR9
Recommendation: Updates of precision medicine in type 2 diabetes — R1/PR9 Open
Diabetes mellitus is prevalent worldwide and affects 1 in 10 adults. Despite the successful development of glucose-lowering drugs, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 inhibitors rece…
View article: Recommendation: Updates of precision medicine in type 2 diabetes — R0/PR4
Recommendation: Updates of precision medicine in type 2 diabetes — R0/PR4 Open
Diabetes mellitus is prevalent worldwide and affects 1 in 10 adults. Despite the successful development of glucose-lowering drugs, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 inhibitors rece…
View article: Piezo1 in vascular remodeling of atherosclerosis and pulmonary arterial hypertension: A potential therapeutic target
Piezo1 in vascular remodeling of atherosclerosis and pulmonary arterial hypertension: A potential therapeutic target Open
Vascular remodeling (VR) is a structural and functional change of blood vessels to adapt to the changes of internal and external environment. It is one of the common pathological features of many vascular proliferative diseases. The proces…
View article: P1305: HSA_CIRC_0001599 REGULATES IL18 LEVELS IN AGVHD VIA CERNA MECHANISM
P1305: HSA_CIRC_0001599 REGULATES IL18 LEVELS IN AGVHD VIA CERNA MECHANISM Open
Background: AGVHD (acute graft-versus-host disease) is one of the major complications after hematopoietic stem cell transplantation, and severe aGVHD not only seriously affects the outcome of transplantation but also may pose a threat to t…
View article: Correction to: CDK5 Regulates PD-L1 Expression and Cell Maturation in Dendritic Cells of CRSwNP
Correction to: CDK5 Regulates PD-L1 Expression and Cell Maturation in Dendritic Cells of CRSwNP Open
View article: Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model Open
AgNP-coated biliary stents resisted sediment accumulation in this canine model of obstructive jaundice caused by ligation of the CBD.