Marta Cascante
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View article: Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection
Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant global morbidity since 2019. Long COVID, characterized by persistent symptoms after acute infection, may involve endothelial injury. We analyzed endothelia…
View article: Metabolic plasticity drives specific mechanisms of chemotherapy and targeted therapy resistance in metastatic colorectal cancer
Metabolic plasticity drives specific mechanisms of chemotherapy and targeted therapy resistance in metastatic colorectal cancer Open
Microsatellite-stable metastatic colorectal cancer (MSS mCRC) is currently treated with chemotherapy and targeted agents based on RAS and BRAF mutational status. Although these therapies offer initial benefit, most patients rapidly develop…
View article: From Current Therapeutics to Multitarget Ligands: A Review of Diabetes Pharmacological Treatments
From Current Therapeutics to Multitarget Ligands: A Review of Diabetes Pharmacological Treatments Open
Diabetes is a chronic and complex pathological syndrome that includes a series of disorders and imbalances, whose first characterization is hyperglycemia, although, as it is a multifactorial phenomenon, it requires risk reduction strategie…
View article: Using control bias to identify initial targets for bioproduction improvement
Using control bias to identify initial targets for bioproduction improvement Open
Sensitivity analysis of bioprocess metabolic reaction networks analysis allows the prediction of system parameters such as those associated with the enzyme activity of certain reaction steps which significantly affect the overall productio…
View article: Glutaminase as a metabolic target of choice to counter acquired resistance to Palbociclib by colorectal cancer cells
Glutaminase as a metabolic target of choice to counter acquired resistance to Palbociclib by colorectal cancer cells Open
Several mechanisms of resistance of cancer cells to cyclin-dependent kinase inhibitors (CDKi) have been identified, including the upregulation of metabolic regulators such as glutaminase. However, whether such resistance mechanisms represe…
View article: Mathematical Modeling Unveils a New Role for Transient Mitochondrial Permeability Transition in ROS Damage Prevention
Mathematical Modeling Unveils a New Role for Transient Mitochondrial Permeability Transition in ROS Damage Prevention Open
We have previously shown that the mitochondrial respiratory chain (RC) can switch between the following two states: (i) an “ATP-producing” state characterized by the low production of reactive oxygen species (ROS), the vigorous translocati…
View article: Metabolic plasticity underlying resistance to anti-PD1 retifanlimab and the arginase inhibitor CB-1158, in microsatellite-stable colorectal cancer patient-derived organoids co-cultured with tumor-infiltrating lymphocytes
Metabolic plasticity underlying resistance to anti-PD1 retifanlimab and the arginase inhibitor CB-1158, in microsatellite-stable colorectal cancer patient-derived organoids co-cultured with tumor-infiltrating lymphocytes Open
Aim Cancer immunotherapies show low activity in metastatic microsatellite-stable (MSS) colorectal cancer (CCR) patients. Arginase 1 inhibitors have shown activity in pre-clinical animal models associated with PD-1 inhibitors but failed in …
View article: Correction: Povo-Retana et al. Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer Therapy. Molecules 2024, 29, 331
Correction: Povo-Retana et al. Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer Therapy. Molecules 2024, 29, 331 Open
In the published publication [...]
View article: Novel protocol for metabolomics data normalization and biomarker discovery in human tears
Novel protocol for metabolomics data normalization and biomarker discovery in human tears Open
Objectives Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol for no…
View article: Current efficacy of immune checkpoint inhibitors in microsatellite unstable colorectal cancer and potential biomarkers
Current efficacy of immune checkpoint inhibitors in microsatellite unstable colorectal cancer and potential biomarkers Open
Microsatellite unstable (MSI) colorectal cancer (CRC) tumors have a high mutational load (particularly frame-shift mutations) that creates numerous neoantigens that are presented to major histocompatibility complex molecules and recognized…
View article: Metabolic Singularities in Microsatellite-Stable Colorectal Cancer: Identifying Key Players in Immunosuppression to Improve the Immunotherapy Response
Metabolic Singularities in Microsatellite-Stable Colorectal Cancer: Identifying Key Players in Immunosuppression to Improve the Immunotherapy Response Open
Although immune checkpoint inhibitor (ICI) therapy is currently the standard of care in microsatellite-unstable (MSI) metastatic colorectal cancer (CRC), ICI therapy, alone or in combination with other therapies, is not a treatment approac…
View article: Synthesis and biological evaluation of novel carnosic acid derivatives with anticancer activity
Synthesis and biological evaluation of novel carnosic acid derivatives with anticancer activity Open
Novel derivatives of carnosic acid 1 with ester or carbamate groups at C-20 and derivatives with these functional groups combined with benzylic modifications (C-7) were synthesized and evaluated in a colorectal cancer cell line (HCT116).
View article: Design, Synthesis, and Biological Evaluation of Novel Urea-Containing Carnosic Acid Derivatives with Anticancer Activity
Design, Synthesis, and Biological Evaluation of Novel Urea-Containing Carnosic Acid Derivatives with Anticancer Activity Open
A series of novel carnosic acid 1 derivatives incorporating urea moieties at the C-20 position was synthesized and evaluated for their antiproliferative activity against the HCT116 colorectal cancer cell line. Most derivatives demonstrated…
View article: Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS‐CoV2‐Induced Cytokine Storm. A Fluxomic Approach
Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS‐CoV2‐Induced Cytokine Storm. A Fluxomic Approach Open
The cytokine storm associated with SARS‐CoV‐2 infection is one of the most distinctive pathological signatures in COVID‐19 patients. Macrophages respond to this pro‐inflammatory challenge by reprogramming their functional and metabolic phe…
View article: Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes
Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes Open
Neuregulin 4 (Nrg4) is an adipokine that belongs to the epidermal growth factor family and binds to ErbB4 tyrosine kinase receptors. In 3T3-L1 adipocytes, the downregulation of Nrg4 expression enhances inflammation and autophagy, resulting…
View article: Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10
Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 Open
Antiviral signaling, immune response and cell metabolism are dysregulated by SARS‐CoV‐2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and…
View article: Induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors
Induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors Open
Viral accessory proteins play critical roles in viral escape form host innate immune responses and in viral inflammatory pathogenesis. Here we show that the SARS-CoV-2 accessory protein, ORF9b, but not other SARS-CoV-2 accessory proteins (…
View article: Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer Therapy
Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer Therapy Open
Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural analogues that differ on the tetrahydroisoquinoline moiety of…
View article: Glutaminase as a metabolic target of choice to counter acquired resistance to Palbociclib by colorectal cancer cells
Glutaminase as a metabolic target of choice to counter acquired resistance to Palbociclib by colorectal cancer cells Open
Summary Several mechanisms of resistance of cancer cells to cyclin-dependent kinase inhibitors (CDKi) have been identified, including the upregulation of metabolic regulators such as glutaminase. However, whether such mechanisms and target…
View article: Exploring the effect of the axial ligands on the anticancer activity of [C,N,N′] Pt(<scp>iv</scp>) cyclometallated compounds
Exploring the effect of the axial ligands on the anticancer activity of [C,N,N′] Pt(<span>iv</span>) cyclometallated compounds Open
The anticancer activity of [C,N,N′] Pt( iv ) cyclometallated compounds with different axial ligands is higher for the most easily reduced compounds while the efficiency of binding to DNA is less relevant.
View article: Circulating metabolic markers after surgery identify patients at risk for severe postoperative complications: a prospective cohort study in colorectal cancer
Circulating metabolic markers after surgery identify patients at risk for severe postoperative complications: a prospective cohort study in colorectal cancer Open
Background: Early detection of postoperative complications after colorectal cancer (CRC) surgery is associated with improved outcomes. The aim was to investigate early metabolomics signatures capable to detect patients at risk for severe p…
View article: Retifanlimab and the arginase inhibitor CB-1158 show low activity in microsatellite-stable colorectal cancer patient-derived organoids co-cultured with tumor-infiltrating lymphocytes
Retifanlimab and the arginase inhibitor CB-1158 show low activity in microsatellite-stable colorectal cancer patient-derived organoids co-cultured with tumor-infiltrating lymphocytes Open
Background Cancer immunotherapies show low activity in metastatic microsatellite-stable (MSS) colorectal cancer (CCR) patients. Arginase 1 inhibitors have shown activity in pre-clinical models associated with PD-1 inhibitors. Methods We es…
View article: Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction
Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction Open
Compelling evidence has accumulated on the role of oxidative stress on the endothelial cell (EC) dysfunction in acute coronary syndrome. Unveiling the underlying metabolic determinants has been hampered by the scarcity of appropriate cell …
View article: Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer Open
Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor for microsatellite stable tumors and pembrolizumab for microsatellite instable tumors. Ho…
View article: Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10
Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 Open
Antiviral signaling, immune response and cell metabolism in human body are dysregulated by SARS-CoV-2, the causative agent of the COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant…