Mauricio Rojas
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View article: Charting a transformational course toward a safe and just future: the Earth Commission’s contribution
Charting a transformational course toward a safe and just future: the Earth Commission’s contribution Open
Humans are now operating well outside the planetary conditions that enabled stable and equitable development. The situation is urgent — we need a swift and profound shift in direction — a collective transformation. In response, the Earth C…
View article: An Intrinsic-hoc Framework for Heterogeneous Cellular Senescence Elucidation Using Deep Graph Representation Learning and Experimental Validation
An Intrinsic-hoc Framework for Heterogeneous Cellular Senescence Elucidation Using Deep Graph Representation Learning and Experimental Validation Open
Characterizing senescent cells and identifying corresponding senescence-associated genes within complex tissues is critical for our understanding of aging and age-related diseases. We present DeepSAS, an intrinsic-hoc framework for elucida…
View article: EXTRACELLULAR VESICLES FROM LUPUS NEPHRITIS PATIENTS INDUCE CHANGES IN THE TRANSCRIPTIONAL PROFILE OF MONOCYTES THAT RESEMBLE SLAN+ MONOCYTES
EXTRACELLULAR VESICLES FROM LUPUS NEPHRITIS PATIENTS INDUCE CHANGES IN THE TRANSCRIPTIONAL PROFILE OF MONOCYTES THAT RESEMBLE SLAN+ MONOCYTES Open
PV114 / #325 Poster Topic: AS12 - Genetics, Epigenetics, Transcriptomics Background/Purpose Extracellular Vesicles (EVs) are a source of autoantigens that can be recognized by circulating monocytes and can also form immune complexes. Lupus…
View article: SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms
SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms Open
Cellular senescence is a major hallmark of aging. Senescence is defined as an irreversible growth arrest observed when cells are exposed to a variety of stressors including DNA damage, oxidative stress, or nutrient deprivation. While senes…
View article: Pluronic F127/lecithin PLGA nanoparticles as carriers of monocyte-targeted jakinibs: a potential therapeutic platform
Pluronic F127/lecithin PLGA nanoparticles as carriers of monocyte-targeted jakinibs: a potential therapeutic platform Open
Aim: In this study, PLGA nanoparticles (PNPs) emulsified in Pluronic F127 (F127)/Lecithin (LEC) were designed to load Itacitinib (ITA), a selective JAK1 inhibitor, for targeting human monocytes.Materials & methods: The physicochemical char…
View article: Circulating extracellular vesicles in Systemic Lupus Erythematosus: physicochemical properties and phenotype
Circulating extracellular vesicles in Systemic Lupus Erythematosus: physicochemical properties and phenotype Open
Objective This study aimed to identify the physicochemical and phenotypic characteristics of circulating Extracellular Vesicles (EVs) in the plasma of patients with SLE, with or without Lupus Nephritis (LN), and their potential utility as …
View article: NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy
NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy Open
Background. Since 2010, several cases of a new vasculopathy induced by the use of levamisole-adulterated cocaine (LAC) have been reported. This vasculopathy is characterized by retiform purpura, earlobe necrosis, multisystem compromise, an…
View article: Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy
Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy Open
Chronic inflammation and dysregulated repair mechanisms after epithelial damage have been implicated in chronic obstructive pulmonary disease (COPD). However, the lack of ex vivo-models that accurately reflect multicellular lung tissue hin…
View article: scResolve: Recovering single cell expression profiles from multi-cellular spatial transcriptomics
scResolve: Recovering single cell expression profiles from multi-cellular spatial transcriptomics Open
Many popular spatial transcriptomics techniques lack single-cell resolution. Instead, these methods measure the collective gene expression for each location from a mixture of cells, potentially containing multiple cell types. Here, we deve…
View article: Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases Open
Autoimmune diseases are chronic conditions that result from an inadequate immune response to self-antigens and affect many people worldwide. Their signs, symptoms, and clinical severity change throughout the course of the disease, therefor…
View article: Lippia origanoides Essential Oil or Thymol in Combination with Fluconazole Produces Damage to Cells and Reverses the Azole-Resistant Phenotype of a Candida tropicalis Strain
Lippia origanoides Essential Oil or Thymol in Combination with Fluconazole Produces Damage to Cells and Reverses the Azole-Resistant Phenotype of a Candida tropicalis Strain Open
Candida tropicalis is one of the most pathogenic species within the genus. Increased antifungal resistance has been reported, which is in part due to the organism’s ability to form biofilms. In natural products derived from plants, such as…
View article: Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls
Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls Open
Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in…
View article: Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants
Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants Open
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to nongenetic factors, have been consistently associated with IPF. Rare variants identified …
View article: Nanoparticles Targeting Monocytes and Macrophages as Diagnostic and Therapeutic Tools for Autoimmune Diseases
Nanoparticles Targeting Monocytes and Macrophages as Diagnostic and Therapeutic Tools for Autoimmune Diseases Open
The diagnosis and treatment of autoimmune diseases are major challenges. Their signs, symptoms, and their clinical severity change throughout the course of the disease. The available treatments for these conditions do not result in complet…
View article: NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease
NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease Open
Cells respond to a myriad of stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a senescence-associated-secretory-phenotype (SASP). The heterogeneity of senescent cells (SnCs) and their SASP is v…
View article: Altered B cell phenotype and CD27+ memory B cells are associated with clinical features and environmental exposure in Colombian systemic lupus erythematosus patients
Altered B cell phenotype and CD27+ memory B cells are associated with clinical features and environmental exposure in Colombian systemic lupus erythematosus patients Open
Background B lymphocytes are dysregulated in Systemic Lupus Erythematosus (SLE) including the expansion of extrafollicular B cells in patients with SLE of African American ancestry, which is associated with disease activity and nephritis. …
View article: Editorial: Defining and Characterizing Respiratory Disease in an Aging Population
Editorial: Defining and Characterizing Respiratory Disease in an Aging Population Open
EDITORIAL article Front. Med., 07 April 2022Sec. Pulmonary Medicine https://doi.org/10.3389/fmed.2022.889834
View article: A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis diagnosis
A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis diagnosis Open
An estimated one third of tuberculosis (TB) cases go undiagnosed or unreported. Sputum samples, widely used for TB diagnosis, are inefficient at detecting infection in children and paucibacillary (smear negative) patients. Indeed, developi…
View article: Effect of supplementation of freezing media with isoespintanol on functional integrity of equine semen
Effect of supplementation of freezing media with isoespintanol on functional integrity of equine semen Open
Adding antioxidants to semen extender has become one of the major strategies to reduce the damage caused by freezing to stallion sperm. Isoespintanol (Iso) is a natural antioxidant that is known as a good free radical scavenger. The aim of…
View article: Differences in Endothelial Activation and Dysfunction Induced by Antiphospholipid Antibodies Among Groups of Patients With Thrombotic, Refractory, and Non-refractory Antiphospholipid Syndrome
Differences in Endothelial Activation and Dysfunction Induced by Antiphospholipid Antibodies Among Groups of Patients With Thrombotic, Refractory, and Non-refractory Antiphospholipid Syndrome Open
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by pregnancy morbidity or thrombosis and persistent antiphospholipid antibodies (aPL) that bind to the endothelium and induce endothelial activation, which is evidence…
View article: Effect of a Surfactant Additive on Drug Transport and Distribution Uniformity After Aerosol Delivery to <i>Ex Vivo</i> Lungs
Effect of a Surfactant Additive on Drug Transport and Distribution Uniformity After Aerosol Delivery to <i>Ex Vivo</i> Lungs Open
Background: Inhaled drug delivery can be limited by heterogeneous dose distribution. An additive that would disperse drug over the internal surfaces of the lung after aerosol deposition could improve dosing uniformity and increase the trea…