Mara Hon
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View article: Tuning insulin receptor signaling using de novo-designed agonists
Tuning insulin receptor signaling using de novo-designed agonists Open
Insulin binding induces conformational changes in the insulin receptor (IR) that activate the intracellular kinase domain and the protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways, regulating metabolism and prolif…
View article: Tuning Insulin Receptor Signaling Using<i>De Novo</i>Designed Agonists
Tuning Insulin Receptor Signaling Using<i>De Novo</i>Designed Agonists Open
Summary Binding of insulin to the insulin receptor (IR) induces conformational changes in the extracellular portion of the receptor that lead to activation of the intracellular kinase domain and the AKT and MAPK pathways, and downstream mo…
View article: A Hot Saturn Orbiting an Oscillating Late Subgiant Discovered by TESS
A Hot Saturn Orbiting an Oscillating Late Subgiant Discovered by TESS Open
We present the discovery of HD 221416 b, the first transiting planet identified by the Transiting Exoplanet Survey Satellite (TESS) for which asteroseismology of the host star is possible. HD 221416 b (HIP 116158, TOI-197) is a bright (V =…