Mara Lawniczak
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View article: Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia
Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia Open
Microsporidia are single-celled, obligately intracellular parasites with growing public health, agricultural, and economic importance. Despite this, Microsporidia remain relatively enigmatic, with many aspects of their biology and evolutio…
View article: Genetic isolation drives divergent insecticide resistance between coastal and western Kenya Anopheles funestus populations
Genetic isolation drives divergent insecticide resistance between coastal and western Kenya Anopheles funestus populations Open
Escalating levels of insecticide resistance and adaptive changes in mosquito populations threaten recent gains in malaria control. Understanding the molecular, ecological, and evolutionary processes driving these transformations is importa…
View article: Genomic diversity of the African malaria vector <i>Anopheles funestus</i>
Genomic diversity of the African malaria vector <i>Anopheles funestus</i> Open
Anopheles funestus s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and 45 historic specimens (collected 1927 t…
View article: Constraints on chromosome evolution revealed by the 229 chromosome pairs of the Atlas blue butterfly
Constraints on chromosome evolution revealed by the 229 chromosome pairs of the Atlas blue butterfly Open
Chromosomal arrangements are important for processes including genetic recombination, adaptation, and speciation. Related taxa often possess similar numbers of chromosomes, but some groups show remarkable variation in chromosome numbers. M…
View article: The Earth BioGenome Project Phase II: illuminating the eukaryotic tree of life
The Earth BioGenome Project Phase II: illuminating the eukaryotic tree of life Open
The Earth BioGenome Project (EBP) aims to “sequence life for the future of life” by generating high-quality reference genome sequences for all recognized eukaryotic species, thereby building a rich knowledge base to inform conservation, in…
View article: A chromosomal reference genome sequence for the malaria mosquito, Anopheles (Nyssorhynchus) aquasalis, Curry, 1932
A chromosomal reference genome sequence for the malaria mosquito, Anopheles (Nyssorhynchus) aquasalis, Curry, 1932 Open
We present a genome assembly from an individual female Anopheles (Nyssorhynchus) aquasalis (a malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), from a wild population in French Guiana. The genome sequence is 177 megabases in span…
View article: An atlas of positive selection in the genomes of major malaria vectors
An atlas of positive selection in the genomes of major malaria vectors Open
Insecticide resistance poses a major threat to malaria control efforts in Africa, yet our understanding of the genomic basis of adaptation in malaria vectors remains incomplete. Here we present a comprehensive atlas of recent positive sele…
View article: Breaking the cold chain: solutions for room temperature preservation of mosquitoes leading to high quality reference genomes
Breaking the cold chain: solutions for room temperature preservation of mosquitoes leading to high quality reference genomes Open
The Earth BioGenome Project (EBP) is a global endeavour to produce reference genomes for all described eukaryotic species. The majority of described species are arthropods, which tend to be small and require taxonomic expertise to identify…
View article: Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal
Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal Open
View article: Signatures of selection and mechanisms of insecticide resistance in Ugandan<i>Anopheles funestus</i>: Insights from embedding translational genomics into the LLINEUP cluster randomised trial
Signatures of selection and mechanisms of insecticide resistance in Ugandan<i>Anopheles funestus</i>: Insights from embedding translational genomics into the LLINEUP cluster randomised trial Open
In response to the emerging threat of insecticide resistance in malaria vectors, insecticides are being repurposed for vector control or developed de novo . Good stewardship of these finite new resources is essential if disease control pro…
View article: Assessing the population genetic structure and demographic history of <i>Anopheles gambiae</i> and <i>An. arabiensis</i> at island and mainland sites in Uganda: Implications for testing novel malaria vector control approaches
Assessing the population genetic structure and demographic history of <i>Anopheles gambiae</i> and <i>An. arabiensis</i> at island and mainland sites in Uganda: Implications for testing novel malaria vector control approaches Open
Despite substantial investments in malaria control, the disease remains a major burden in sub-Saharan Africa, particularly Uganda. Novel tools such as gene drive systems are being developed to suppress malaria vector populations, but their…
View article: Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia
Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia Open
Microsporidia are single-celled, obligately intracellular parasites with growing public health, agricultural, and economic importance. Despite this, Microsporidia remain relatively enigmatic, with many aspects of their biology and evolutio…
View article: On the path to reference genomes for all biodiversity: lessons learned and laboratory protocols created in the Sanger Tree of Life core laboratory over the first 2000 species
On the path to reference genomes for all biodiversity: lessons learned and laboratory protocols created in the Sanger Tree of Life core laboratory over the first 2000 species Open
Since its inception in 2019, the Tree of Life programme at the Wellcome Sanger Institute has released high-quality, chromosomally-resolved reference genome assemblies for over 2000 species. Tree of Life has at its core multiple teams, each…
View article: Two chromosomal reference genome sequences for the malaria mosquito, Anopheles (Nyssorhynchus) darlingi, Root, 1926 from French Guiana and Peru
Two chromosomal reference genome sequences for the malaria mosquito, Anopheles (Nyssorhynchus) darlingi, Root, 1926 from French Guiana and Peru Open
We present two genome assemblies, each generated from individual female Anopheles (Nyssorhynchus) darlingi (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), from wild populations in French Guiana and Peru. The genome sequenc…
View article: The 229 chromosomes of the Atlas blue butterfly reveal rules constraining chromosome evolution in Lepidoptera
The 229 chromosomes of the Atlas blue butterfly reveal rules constraining chromosome evolution in Lepidoptera Open
Chromosomal arrangements are important for processes including genetic recombination, adaptation, and speciation. Related taxa often possess similar numbers of chromosomes, but some groups show remarkable variation in chromosome numbers. M…
View article: A chromosomal reference genome sequence for the northern house mosquito, Culex pipiens form pipiens, Linnaeus, 1758
A chromosomal reference genome sequence for the northern house mosquito, Culex pipiens form pipiens, Linnaeus, 1758 Open
We present a genome assembly from an individual female Culex pipiens sensu stricto (the northern house mosquito; Arthropoda; Insecta; Diptera; Culicidae), from a wild population in Sweden. The genome sequence is 533 megabases in span. Most…
View article: CiFi: Accurate long-read chromosome conformation capture with low-input requirements
CiFi: Accurate long-read chromosome conformation capture with low-input requirements Open
Hi-C characterizes three-dimensional chromatin organization, facilitates haplotype phasing, and enables genome-assembly scaffolding, but encounters difficulties across complex regions. By coupling chromosome conformation capture (3C) with …
View article: A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection
A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection Open
The mosquito midgut functions as a key interface between pathogen and vector. However, studies of midgut physiology and virus infection dynamics are scarce, and in Culex tarsalis— an extremely efficient vector of West Nile virus (WNV) — no…
View article: Best-practice guidance for Earth BioGenome Project sample collection and processing: progress and challenges in biodiverse reference genome creation
Best-practice guidance for Earth BioGenome Project sample collection and processing: progress and challenges in biodiverse reference genome creation Open
The Earth BioGenome Project has the extremely ambitious goal of generating, at scale, high-quality reference genomes across the entire Tree of Life. Currently in its first phase, the project is targeting family-level representatives and is…
View article: On the path to reference genomes for all biodiversity: laboratory protocols and lessons learned from processing over 2,000 species in the Sanger Tree of Life
On the path to reference genomes for all biodiversity: laboratory protocols and lessons learned from processing over 2,000 species in the Sanger Tree of Life Open
Since its inception in 2019, the Tree of Life programme at the Wellcome Sanger Institute has released high-quality, chromosomally resolved reference genome assemblies for over 2,000 species. Tree of Life has at its core multiple teams, eac…
View article: Genomic diversity of the African malaria vector<i>Anopheles funestus</i>
Genomic diversity of the African malaria vector<i>Anopheles funestus</i> Open
Anopheles funestus s.s. is a formidable human malaria vector across sub-Saharan Africa. To understand how the species is evolving, especially in response to malaria vector control, we sequenced 656 modern specimens (collected 2014-2018) an…
View article: Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis
Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis Open
Bill & Melinda Gates Foundation.
View article: A chromosomal reference genome sequence for the malaria mosquito, Anopheles nili, Theobald, 1904
A chromosomal reference genome sequence for the malaria mosquito, Anopheles nili, Theobald, 1904 Open
We present a genome assembly from an individual male Anopheles nili (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), from a wild population in Cameroon. The genome sequence is 195 megabases in span. Most of the assembly is …
View article: Discovery of Knock‐Down Resistance in the Major African Malaria Vector <i>Anopheles funestus</i>
Discovery of Knock‐Down Resistance in the Major African Malaria Vector <i>Anopheles funestus</i> Open
A major insecticide resistance mechanism in insect pests is knock‐down resistance ( kdr ) caused by mutations in the voltage‐gated sodium channel ( Vgsc ) gene. Despite being common in most malaria Anopheles vector species, kdr mutations h…
View article: Illuminating Entomological Dark Matter with DNA Barcodes in an Era of Insect Decline, Deep Learning, and Genomics
Illuminating Entomological Dark Matter with DNA Barcodes in an Era of Insect Decline, Deep Learning, and Genomics Open
Most insects encountered in the field are initially entomological dark matter in that they cannot be identified to species while alive. This explains the enduring quest for efficient ways to identify collected specimens. Morphological tool…
View article: A chromosomal reference genome sequence for the malaria mosquito, Anopheles marshallii, Theobald, 1903
A chromosomal reference genome sequence for the malaria mosquito, Anopheles marshallii, Theobald, 1903 Open
We present a genome assembly from an individual female Anopheles marshallii (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae) from Lopé, Gabon. The genome sequence is 225.7 megabases in span. Most of the assembly is scaffolde…
View article: Chromosomal reference genome sequences for the malaria mosquito, Anopheles coustani, Laveran, 1900
Chromosomal reference genome sequences for the malaria mosquito, Anopheles coustani, Laveran, 1900 Open
We present genome assembly from individual female An. coustani (African malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae) from Lopé, Gabon. The genome sequence is 270 megabases in span. Most of the assembly is scaffolded into thre…
View article: A chromosomal reference genome sequence for the malaria mosquito, Anopheles maculipalpis, Giles, 1902
A chromosomal reference genome sequence for the malaria mosquito, Anopheles maculipalpis, Giles, 1902 Open
We present a genome assembly from an individual female Anopheles maculipalpis (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae). The genome sequence is 224 megabases in span. Most of the assembly is scaffolded into three chro…
View article: Improved species assignments across the entire Anopheles genus using targeted sequencing
Improved species assignments across the entire Anopheles genus using targeted sequencing Open
Accurate species identification of the mosquitoes in the genus Anopheles is of crucial importance to implement malaria control measures and monitor their effectiveness. We use a previously developed amplicon panel (ANOSPP) that retrieves s…
View article: A single-cell atlas of the<i>Culex tarsalis</i>midgut during West Nile virus infection
A single-cell atlas of the<i>Culex tarsalis</i>midgut during West Nile virus infection Open
The mosquito midgut functions as a key interface between pathogen and vector. However, studies of midgut physiology and virus infection dynamics are scarce, and in Culex tarsalis – an extremely efficient vector of West Nile virus (WNV) – n…