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View article: miRNA and Its Implications in the Treatment Resistance in Breast Cancer—Narrative Review of What Do We Know So Far
miRNA and Its Implications in the Treatment Resistance in Breast Cancer—Narrative Review of What Do We Know So Far Open
Breast cancer remains a leading cause of cancer-related mortality worldwide, with treatment resistance and tumor heterogeneity posing major clinical challenges. MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have eme…
View article: Surgical Techniques for Urinary Incontinence in Young Women—Narrative Review
Surgical Techniques for Urinary Incontinence in Young Women—Narrative Review Open
Urinary incontinence (UI) is a widespread worldwide gynecological pathology with a negative impact on women’s quality of life. We performed a narrative review and present a general, descriptive, and comprehensive perspective about surgical…
View article: The Career Decision of Medical Students: A Tool for Organizational Psychology in the Healthcare System
The Career Decision of Medical Students: A Tool for Organizational Psychology in the Healthcare System Open
Background: The deficit of medical staff in various health care systems points out the need for a more detailed strategic management toward sustainability in human resources. The purpose of this study is to explore the relationships linkin…
View article: Antimicrobial and immunomodulatory activity of natural bioactive compounds – an in vitro investigation with potential applications in managing Hidradenitis Suppurativa
Antimicrobial and immunomodulatory activity of natural bioactive compounds – an in vitro investigation with potential applications in managing Hidradenitis Suppurativa Open
Background Natural bioactive compounds such as terpenoids and phenolic acids have emerged as promising agents in dermatological research due to their proven antioxidant, antimicrobial and anti-inflammatory properties. Hidradenitis Suppurat…
View article: Virulence and Antibiotic Resistance Profiles of Staphylococcus aureus Isolated from Epidermal Growth Factor Receptor Inhibitors-Associated Skin Lesions
Virulence and Antibiotic Resistance Profiles of Staphylococcus aureus Isolated from Epidermal Growth Factor Receptor Inhibitors-Associated Skin Lesions Open
Cutaneous adverse reactions (CARs) are common complications of epidermal growth factor receptor (EGFR) inhibitor therapy, with papulopustular eruptions and paronychia being the most frequent. Growing scientific evidence implies that Staphy…
View article: CA125 as a Potential Biomarker in Non-Malignant Serous Effusions: Diagnostic and Prognostic Considerations
CA125 as a Potential Biomarker in Non-Malignant Serous Effusions: Diagnostic and Prognostic Considerations Open
Background/Objectives: Carbohydrate antigen 125 (CA125) is a glycoprotein commonly overexpressed in epithelial ovarian cancer and widely recognized as a tumor marker. However, elevated CA125 levels are also observed in various non-malignan…
View article: Therapeutic Approaches in Monkeypox Infections
Therapeutic Approaches in Monkeypox Infections Open
Monkeypox virus, a zoonotic orthopoxvirus, has emerged as a significant global health concern following recent outbreaks in non-endemic regions. While previously confined to Central and West Africa, monkeypox virus has been recently detect…
View article: The Career Decision of Medical Students: A Tool for Organizational Psychology in Healthcare System
The Career Decision of Medical Students: A Tool for Organizational Psychology in Healthcare System Open
Background: The deficit of medical staff in various health care systems points out the need for a more detailed strategic management toward sustainability in human resources. The purpose of this study is to explore the relationships linkin…
View article: Nanotechnology-driven enhancement and modulation of immune responses in monkeypox and respiratory syncytial virus nanovaccine research
Nanotechnology-driven enhancement and modulation of immune responses in monkeypox and respiratory syncytial virus nanovaccine research Open
The global health landscape continues to face significant challenges from emerging and re-emerging viral pathogens, notably Monkeypox virus (MPXV) and Respiratory Syncytial Virus (RSV). Traditional vaccine approaches often fall short in pr…
View article: Bullous Pemphigoid Overlapping Psoriasis Vulgaris: A Rare Case Report and Literature Review
Bullous Pemphigoid Overlapping Psoriasis Vulgaris: A Rare Case Report and Literature Review Open
Bullous pemphigoid (BP) is a rare autoimmune disease, primarily affecting elderly individuals, that significantly impacts the patient’s quality of life. In contrast, psoriasis vulgaris (PV) is a common, chronic, immune-mediated skin condit…
View article: Silver Nanoparticles Functionalized with Polymeric Substances to Reduce the Growth of Planktonic and Biofilm Opportunistic Pathogens
Silver Nanoparticles Functionalized with Polymeric Substances to Reduce the Growth of Planktonic and Biofilm Opportunistic Pathogens Open
The global rise in antimicrobial resistance, particularly among ESKAPE pathogens, has intensified the demand for alternative therapeutic strategies. Silver nanoparticles (AgNPs) have exhibited broad-spectrum antimicrobial activity and repr…
View article: Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection
Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection Open
The gut microbiome, a complex community of microorganisms residing in the intestinal tract, plays a dual role in colorectal cancer (CRC) development, acting both as a contributing risk factor and as a protective element. This review explor…
View article: Promising Antimicrobial Activities of Essential Oils and Probiotic Strains on Chronic Wound Bacteria
Promising Antimicrobial Activities of Essential Oils and Probiotic Strains on Chronic Wound Bacteria Open
Background: Disruption of the natural balance of the skin microbiota can impair wound healing and contribute to chronic infections. Identifying the bacterial species involved and understanding their antimicrobial susceptibility profiles ar…
View article: Enhancing Prognosis in Advanced Ovarian Cancer: Primary Cytoreductive Surgery and Adjuvant Chemotherapy or Neoadjuvant Chemotherapy and Interval Cytoreduction—A Single-Center Retrospective Observational Study
Enhancing Prognosis in Advanced Ovarian Cancer: Primary Cytoreductive Surgery and Adjuvant Chemotherapy or Neoadjuvant Chemotherapy and Interval Cytoreduction—A Single-Center Retrospective Observational Study Open
Background: Advanced-stage ovarian cancer presents a significant therapeutic challenge, with primary cytoreductive surgery (PCS) followed by chemotherapy and neoadjuvant chemotherapy (NACT) with interval debulking surgery (IDS) as the two …
View article: Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review
Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review Open
View article: Phenotypic and Genotypic Bacterial Virulence and Resistance Profiles in Hidradenitis Suppurativa
Phenotypic and Genotypic Bacterial Virulence and Resistance Profiles in Hidradenitis Suppurativa Open
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition, primarily affecting young individuals, with a significant impact on their quality of life due to recurrent, painful nodules, abscesses, and oozing sinus tracts, primar…
View article: From Microbial Ecology to Clinical Challenges: The Respiratory Microbiome’s Role in Antibiotic Resistance
From Microbial Ecology to Clinical Challenges: The Respiratory Microbiome’s Role in Antibiotic Resistance Open
Antibiotic resistance represents a growing public health threat, with airborne drug-resistant strains being especially alarming due to their ease of transmission and association with severe respiratory infections. The respiratory microbiom…
View article: Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression
Unraveling the Skin Microbiome in Hidradenitis Suppurativa: Implications for Treatment and Disease Progression Open
Background: Hidradenitis suppurativa (HS) is a chronic, disabling, and disfiguring inflammatory disease with a complex, incompletely elucidated pathogenesis. The role of skin dysbiosis in the development and progression of HS has not yet b…
View article: Diagnosis and Management of Cancers in Pregnancy: The Results of a Dual Battle Between Oncological Condition and Maternal Environment—Literature Review
Diagnosis and Management of Cancers in Pregnancy: The Results of a Dual Battle Between Oncological Condition and Maternal Environment—Literature Review Open
Cancer during pregnancy presents considerable challenges that arise from various factors, including the diagnostic, prognostic and therapeutic implications of managing cancer in this unique patient population. There is a crucial need for a…
View article: Effective Management of Severe Epidermal Growth Factor Receptor Inhibitors-Induced Papulopustular Eruption With Low-Dose Isotretinoin and Corticosteroids
Effective Management of Severe Epidermal Growth Factor Receptor Inhibitors-Induced Papulopustular Eruption With Low-Dose Isotretinoin and Corticosteroids Open
View article: Exploring the Intersection of Blood Transfusion and Same-Day Computed Tomography Imaging: An Overview of Clinical Risks and Practices
Exploring the Intersection of Blood Transfusion and Same-Day Computed Tomography Imaging: An Overview of Clinical Risks and Practices Open
The use of transfusions, whether involving whole blood or specific blood components, is essential for managing various clinical conditions. Many cases are acute, often requiring post-transfusion imaging evaluation. While there is no absolu…
View article: Correlations between Gut Microbiota and Hematological, Inflammatory, Biochemical and Oxidative Stress Parameters in Treatment-Naïve Psoriasis Patients
Correlations between Gut Microbiota and Hematological, Inflammatory, Biochemical and Oxidative Stress Parameters in Treatment-Naïve Psoriasis Patients Open
Psoriasis is an inflammatory dermatosis with a complex pathogenesis, significantly impacting the quality of life of patients. The role of oxidative stress and gut microbiota in the pathogenesis of this disease is increasingly studied, appe…
View article: Host–Microbiome Crosstalk in Chronic Wound Healing
Host–Microbiome Crosstalk in Chronic Wound Healing Open
The pathogenesis of chronic wounds (CW) involves a multifaceted interplay of biochemical, immunological, hematological, and microbiological interactions. Biofilm development is a significant virulence trait which enhances microbial surviva…
View article: Perspectives on Psoriasiform Adverse Events from Immune Checkpoint Inhibitors: Lessons Learned from Our Practice
Perspectives on Psoriasiform Adverse Events from Immune Checkpoint Inhibitors: Lessons Learned from Our Practice Open
Background: New oncologic therapies, including immune checkpoint inhibitors (ICIs), have revolutionized the survival and prognosis of cancer patients. However, these therapies are often complicated by immune-related adverse effects (irAEs)…
View article: Clinical and microbiological features of host-bacterial interplay in chronic venous ulcers versus other types of chronic skin ulcers
Clinical and microbiological features of host-bacterial interplay in chronic venous ulcers versus other types of chronic skin ulcers Open
Introduction Chronic venous ulcers of the lower limbs develop in the context of advanced venous disease and have a significant impact on the patient’s quality of life, being associated with depression and worrisome suicide rates, as well a…
View article: Cutaneous Adverse Reactions Associated with Tattoos and Permanent Makeup Pigments
Cutaneous Adverse Reactions Associated with Tattoos and Permanent Makeup Pigments Open
Tattooing is the procedure of implanting permanent pigment granules and additives into the dermal layer of the skin, serving various purposes such as decoration, medical identification, or accidental markings. There has been a significant …
View article: Pyoderma Gangrenosum: The Impact of Treatment Non-adherence on Disease Progression
Pyoderma Gangrenosum: The Impact of Treatment Non-adherence on Disease Progression Open
Pyoderma gangrenosum (PG) is a rare, ulcerative, rapidly progressing, destructive, inflammatory cutaneous disease that is both diagnostically and therapeutically challenging. Due to the lack of standardized diagnostic criteria or conclusiv…
View article: Personalization of Minimally-Invasive Aesthetic Procedures with the Use of Ultrasound Compared to Alternative Imaging Modalities
Personalization of Minimally-Invasive Aesthetic Procedures with the Use of Ultrasound Compared to Alternative Imaging Modalities Open
Ultrasonography is a well-tolerated procedure that aids in the targeted esthetic therapies of special cutaneous regions, as well as in the prevention (vascular mapping, identification of previous filler, and others) and management of poten…
View article: An Insight on the Possible Association between Inflammatory Bowel Disease and Biologic Therapy with IL-17 Inhibitors in Psoriasis Patients
An Insight on the Possible Association between Inflammatory Bowel Disease and Biologic Therapy with IL-17 Inhibitors in Psoriasis Patients Open
Psoriasis is a chronic, inflammatory, multisystemic disease which affects approximately 2–3% of the population globally, whose onset is triggered by genetic and environmental factors which activate both dendritic cells and keratinocytes, r…
View article: Antimicrobial Biomaterials for Chronic Wound Care
Antimicrobial Biomaterials for Chronic Wound Care Open
Chronic wounds encompass a myriad of lesions, including venous and arterial leg ulcers, diabetic foot ulcers (DFUs), pressure ulcers, non-healing surgical wounds and others. Despite the etiological differences, chronic wounds share several…