Mara Maldotti
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View article: FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy Open
View article: DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells
DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells Open
View article: 3plex enables deep computational investigation of triplex forming lncRNAs
3plex enables deep computational investigation of triplex forming lncRNAs Open
View article: RNABSdb and 3plex enable deep computational investigation of triplex forming lncRNAs
RNABSdb and 3plex enable deep computational investigation of triplex forming lncRNAs Open
1. Abstract Long non-coding RNAs (lncRNAs) regulate gene expression through different molecular mechanisms, including DNA binding. We curated the first database of RNA Binding Sites (RNABSdb) by harmonising publicly available raw-data of R…
View article: The Emerging Roles of Long Non-Coding RNAs in Intellectual Disability and Related Neurodevelopmental Disorders
The Emerging Roles of Long Non-Coding RNAs in Intellectual Disability and Related Neurodevelopmental Disorders Open
In the human brain, long non-coding RNAs (lncRNAs) are widely expressed in an exquisitely temporally and spatially regulated manner, thus suggesting their contribution to normal brain development and their probable involvement in the molec…
View article: The acetyltransferase p300 is recruited <i>in trans</i> to multiple enhancer sites by lncSmad7
The acetyltransferase p300 is recruited <i>in trans</i> to multiple enhancer sites by lncSmad7 Open
The histone acetyltransferase p300 (also known as KAT3B) is a general transcriptional coactivator that introduces the H3K27ac mark on enhancers triggering their activation and gene transcription. Genome-wide screenings demonstrated that a …
View article: Genome-Wide Analysis of Smad7-Mediated Transcription in Mouse Embryonic Stem Cells
Genome-Wide Analysis of Smad7-Mediated Transcription in Mouse Embryonic Stem Cells Open
Smad7 has been identified as a negative regulator of the transforming growth factor TGF-β pathway by direct interaction with the TGF-β type I receptor (TβR-I). Although Smad7 has also been shown to play TGF-β unrelated functions in the cyt…
View article: The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs Open
View article: Intragenic DNA methylation prevents spurious transcription initiation
Intragenic DNA methylation prevents spurious transcription initiation Open
View article: High-throughput single-base resolution mapping of RNA 2΄-O-methylated residues
High-throughput single-base resolution mapping of RNA 2΄-O-methylated residues Open
Functional characterization of the transcriptome requires tools for the systematic investigation of RNA post-transcriptional modifications. 2΄-O-methylation (2΄-OMe) of the ribose moiety is one of the most abundant post-transcriptional mod…
View article: The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to regulate c-Myc expression
The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to regulate c-Myc expression Open
View article: TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues
TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues Open
Ten-eleven translocation (Tet) genes encode for a family of hydroxymethylase enzymes involved in regulating DNA methylation dynamics. Tet1 is highly expressed in mouse embryonic stem cells (ESCs) where it plays a critical role the pluripot…