Maral Budak
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View article: GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy
GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy Open
Introduction Tuberculosis (TB) remains the primary cause of death due to infectious disease in the world. TB, while treatable, requires an extended course of multiple antibiotics, taking 6–9 months, and many antibiotic regimens have delete…
View article: Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden
Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden Open
Pulmonary infection after inhalation of Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). TB presents with lung granulomas - complex spheroidal structures composed of immune cells and bacteria. Granulomas often have centralized ca…
View article: A novel machine-learning based optimization: identifying new treatment regimens for tuberculosis
A novel machine-learning based optimization: identifying new treatment regimens for tuberculosis Open
Identifying optimization in a system from any discipline requires identifying ways to either maximize or minimize objectives of interest-or even trade-offs between these choices where goals must be balanced. Traditionally, optimal control …
View article: A systematic efficacy analysis of tuberculosis treatment with <scp>BPaL</scp>‐containing regimens using a multiscale modeling approach
A systematic efficacy analysis of tuberculosis treatment with <span>BPaL</span>‐containing regimens using a multiscale modeling approach Open
Tuberculosis (TB) is a life‐threatening infectious disease. The standard treatment is up to 90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol [HRZE]) over long t…
View article: Development and Analysis of Multiscale Models for Tuberculosis: From Molecules to Populations
Development and Analysis of Multiscale Models for Tuberculosis: From Molecules to Populations Open
Although infectious disease dynamics are often analyzed at the macro-scale, increasing numbers of drug-resistant infections highlight the importance of within-host modeling that simultaneously solves across multiple scales to effectively r…
View article: Semi-automated colony-forming unit counting for biosafety level 3 laboratories
Semi-automated colony-forming unit counting for biosafety level 3 laboratories Open
Biosafety level 3 decontamination precautions motivate measuring microbial colonies using consumable photography instead of expensive automated plate counters or smartphones, and assaying drug treatments-with multiple concentrations per tr…
View article: Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens Open
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization initiated an End TB Strategy that aims to reduce TB-related deaths in 2035 by 95…
View article: Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens
Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens Open
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization initiated an End TB Strategy that aims to reduce TB-related deaths in 2035 by 95…
View article: Binaural Processing Deficits Due to Synaptopathy and Myelin Defects
Binaural Processing Deficits Due to Synaptopathy and Myelin Defects Open
Hidden hearing loss (HHL) is a deficit in auditory perception and speech intelligibility that occurs despite normal audiometric thresholds and results from noise exposure, aging, or myelin defects. While mechanisms causing perceptual defic…
View article: Correction: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects
Correction: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects Open
[This corrects the article DOI: 10.1371/journal.pcbi.1008499.].
View article: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects
Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects Open
Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitudes of the sound-evoked auditory nerve compound action potential (CAP). In animal models, HHL can be caused by moderate noise…
View article: Contrasting mechanisms for hidden hearing loss: synaptopathy vs myelin defects
Contrasting mechanisms for hidden hearing loss: synaptopathy vs myelin defects Open
Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitude of the sound-evoked auditory nerve compound action potential (CAP). It has been proposed that in humans HHL leads to speec…
View article: Synaptic Failure Differentially Affects Pattern Formation in Heterogenous Networks
Synaptic Failure Differentially Affects Pattern Formation in Heterogenous Networks Open
The communication of neurons is primarily maintained by synapses, which play a crucial role in the functioning of the nervous system. Therefore, synaptic failure may critically impair information processing in the brain and may underlie ma…