Maralinde R. Abbink
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View article: Molecular underpinnings of programming by early-life stress and the protective effects of early dietary ω6/ω3 ratio, basally and in response to LPS: Integrated mRNA-miRNAs approach
Molecular underpinnings of programming by early-life stress and the protective effects of early dietary ω6/ω3 ratio, basally and in response to LPS: Integrated mRNA-miRNAs approach Open
Early-life stress (ELS) exposure increases the risk for mental disorders, including cognitive impairments later in life. We have previously demonstrated that an early diet with low ω6/ω3 polyunsaturated fatty acid (PUFA) ratio protects aga…
View article: Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS
Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS Open
Brain lipid dysregulation is a hallmark of depression and Alzheimer’s disease, also marked by chronic inflammation. Early-life stress (ELS) and dietary intake of polyunsaturated fatty acids (PUFAs) are risk factors for these pathologies an…
View article: Molecular underpinnings of programming by early-life stress and the protective effects of early dietary ω6/ω3 ratio, basally and in response to LPS: hippocampal mRNA-miRNAs integrated approach
Molecular underpinnings of programming by early-life stress and the protective effects of early dietary ω6/ω3 ratio, basally and in response to LPS: hippocampal mRNA-miRNAs integrated approach Open
Early-life stress (ELS) exposure increases the risk for mental disorders, including cognitive impairments later in life. We have previously demonstrated that a dietary low ω6/ω3 polyunsaturated fatty acid (PUFA) ratio protects against ELS-…
View article: Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS
Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS Open
Brain lipid dysregulation is a hallmark of depression and Alzheimer’s disease, also marked by chronic inflammation. Early-life stress (ELS) and dietary intake of polyunsaturated fatty acids (PUFAs) are risk factors for these pathologies an…
View article: Effects of early-life stress on peripheral and central mitochondria in male mice across ages
Effects of early-life stress on peripheral and central mitochondria in male mice across ages Open
Exposure to early-life stress (ES) increases the vulnerability to develop metabolic diseases as well as cognitive dysfunction, but the specific biological underpinning of the ES-induced programming is unknown. Metabolic and cognitive disor…
View article: Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus
Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus Open
Stress is a potent environmental factor that can confer potent and enduring effects on brain structure and function. Exposure to stress during early life (ELS) has been linked to a wide range of consequences later in life. In particular, E…
View article: Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers
Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers Open
Early-life stress (ES) exposure increases the risk of developing obesity. Breastfeeding can markedly decrease this risk, and it is thought that the physical properties of the lipid droplets in human milk contribute to this benefit. A conce…
View article: Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus
Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus Open
Stress is a potent environmental factor that can confer potent and enduring effects on brain structure and function. Exposure to stress during early life (ELS) has been linked to a wide range of consequences later in life. In particular, E…
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 m…
View article: The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes Open
Early life stress (ES) increases the risk to develop metabolic and brain disorders in adulthood. Breastfeeding (exclusivity and duration) is associated with improved metabolic and neurocognitive health outcomes, and the physical properties…
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 m…
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 m…
View article: Early life stress decreases the proliferation and numbers of adult hypothalamic neural stem cells
Early life stress decreases the proliferation and numbers of adult hypothalamic neural stem cells Open
Early life stress (ELS) is a potent environmental factor that can confer enduring effects on brain structure and function. Exposure to stress during early life has been linked to a wide range of physiopathological consequences later in lif…
View article: The involvement of astrocytes in early‐life adversity induced programming of the brain
The involvement of astrocytes in early‐life adversity induced programming of the brain Open
Early‐life adversity (ELA) in the form of stress, inflammation, or malnutrition, can increase the risk of developing psychopathology or cognitive problems in adulthood. The neurobiological substrates underlying this process remain unclear.…
View article: Increasing availability of ω‐3 fatty acid in the early‐life diet prevents the early‐life stress‐induced cognitive impairments without affecting metabolic alterations
Increasing availability of ω‐3 fatty acid in the early‐life diet prevents the early‐life stress‐induced cognitive impairments without affecting metabolic alterations Open
Exposure to early‐life stress (ES) is associated with cognitive and metabolic deficits in adulthood. The role of early nutrition in programming these long‐term effects is largely unknown. We focused on essential ω‐3 and ω‐6 long‐chain poly…
View article: Programming of the brain by early-life stress : The impact of early nutritional interventions and later life challenges
Programming of the brain by early-life stress : The impact of early nutritional interventions and later life challenges Open
Early-life is a critical period for brain development, during which the brain is shaped for life. This ‘programming’ of the brain can be negatively influenced by adversity in the early-life environment, such as abuse and neglect. Early-lif…
View article: Early‐life stress diminishes the increase in neurogenesis after exercise in adult female mice
Early‐life stress diminishes the increase in neurogenesis after exercise in adult female mice Open
Exposure to early‐life stress (ES) has long‐lasting consequences for later cognition and hippocampal plasticity, including adult hippocampal neurogenesis (AHN), i.e., the generation of new neurons from stem/progenitor cells in the adult hi…
View article: Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice
Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice Open