Marc Behrendt
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View article: Depolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers
Depolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers Open
The majority of somatosensory DRG neurons express GABA A receptors (GABA A R) and depolarise in response to its activation based on the high intracellular chloride concentration maintained by the Na-K-Cl cotransporter type 1 (NKCC1). The t…
View article: Bradykinin-Induced Sensitization of Transient Receptor Potential Channel Melastatin 3 Calcium Responses in Mouse Nociceptive Neurons
Bradykinin-Induced Sensitization of Transient Receptor Potential Channel Melastatin 3 Calcium Responses in Mouse Nociceptive Neurons Open
TRPM3 is a calcium-permeable cation channel expressed in a range of sensory neurons that can be activated by heat and the endogenous steroid pregnenolone sulfate (PS). During inflammation, the expression and function of TRPM3 are both augm…
View article: The structural basis for an on–off switch controlling Gβγ-mediated inhibition of TRPM3 channels
The structural basis for an on–off switch controlling Gβγ-mediated inhibition of TRPM3 channels Open
Significance µ-Opioid receptors, activated by endogenous peptides or opioid drugs such as morphine, dampen the activity of nociceptor cells that detect noxious stimuli and thereby reduce pain. These receptors achieve this clinically import…
View article: Transient receptor potential channels in the context of nociception and pain – recent insights into TRPM3 properties and function
Transient receptor potential channels in the context of nociception and pain – recent insights into TRPM3 properties and function Open
Potential harmful stimuli like heat, mechanical pressure or chemicals are detected by specialized cutaneous nerve fiber endings of nociceptor neurons in a process called nociception. Acute stimulation results in immediate protective reflex…
View article: Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels
Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels Open
Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which also causes important adverse effects. However, µORs are also found on the periphe…
View article: Author response: Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels
Author response: Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Opioids, agonists of µ-opioid receptors (µORs),…
View article: Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122
Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122 Open
Background and Purpose Signalling through phospholipase C (PLC) controls many cellular processes. Much information on the relevance of this important pathway has been derived from pharmacological inhibition of the enzymatic activity of PLC…