Marc Botteman
YOU?
Author Swipe
View article: The Long-Term Healthcare Utilization and Economic Burden of RSV Infection in Children ≤5 Years in Japan: Propensity Score Matched Cohort Study
The Long-Term Healthcare Utilization and Economic Burden of RSV Infection in Children ≤5 Years in Japan: Propensity Score Matched Cohort Study Open
RSV infection had a significant long-term health and economic burden among children infected during their first year of life and later in life. Study findings have import for prevention strategies, currently directed at maternal immunizati…
View article: Understanding what matters to metastatic castration‐resistant prostate cancer (<scp>mCRPC</scp>) patients when considering treatment options: A <scp>US</scp> patient preference survey
Understanding what matters to metastatic castration‐resistant prostate cancer (<span>mCRPC</span>) patients when considering treatment options: A <span>US</span> patient preference survey Open
Background Understanding how patients perceive the efficacy, safety, and administrative burden of treatments for metastatic castration‐resistant prostate cancer (mCRPC) can facilitate shared‐decision making for optimal management. This stu…
View article: Patient Preferences for Benefits, Risks, and Administration Route of Hypomethylating Agents in Myelodysplastic Syndromes
Patient Preferences for Benefits, Risks, and Administration Route of Hypomethylating Agents in Myelodysplastic Syndromes Open
Given equivalent effectiveness across HMAs, patients' preferences for HMA administration method should be considered in treatment decision-making to minimize burden and facilitate adherence.
View article: Assessing the value of orphan drugs using conventional cost-effectiveness analysis: Is it fit for purpose?
Assessing the value of orphan drugs using conventional cost-effectiveness analysis: Is it fit for purpose? Open
View article: Injectable Hypomethylating Agents for Management of Myelodysplastic Syndromes: Patients’ Perspectives on Treatment
Injectable Hypomethylating Agents for Management of Myelodysplastic Syndromes: Patients’ Perspectives on Treatment Open
Patients receiving IV/SC HMAs experienced pain/discomfort and interference with social and daily activities. The introduction of an oral HMA may alleviate some treatment challenges for MDS patients.
View article: Changes in Healthcare Resource Use and Costs in Commercially Insured Insomnia Patients Initiating Suvorexant
Changes in Healthcare Resource Use and Costs in Commercially Insured Insomnia Patients Initiating Suvorexant Open
Article full textThe above graphical abstract represents a summary of the manuscript. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed …
View article: 354 Trends in the Drug-Sparing Effects for Benzodiazepines and Prescription Opioids among Insomnia Patients on Suvorexant in the US
354 Trends in the Drug-Sparing Effects for Benzodiazepines and Prescription Opioids among Insomnia Patients on Suvorexant in the US Open
Introduction Use of benzodiazepines to treat insomnia has been associated with serious side effects and abuse potential. Insomnia patients are at high risk of opioid abuse and better sleep patterns may help to reduce opioid use. This study…
View article: The Long-Term Healthcare Utilization and Economic Burden of RSV Infection in Infants&lt;5 Years in Japan: A Propensity Score Matched Case Control Study
The Long-Term Healthcare Utilization and Economic Burden of RSV Infection in Infants<5 Years in Japan: A Propensity Score Matched Case Control Study Open
View article: Cost effectiveness of axicabtagene ciloleucel versus tisagenlecleucel for adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy in the United States
Cost effectiveness of axicabtagene ciloleucel versus tisagenlecleucel for adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy in the United States Open
In this simulation, axi-cel was a superior treatment option as it is predicted to achieve better outcomes at lower or minimal incremental costs versus tisa-cel.
View article: Corneal cross-linking versus conventional management for keratoconus: a lifetime economic model
Corneal cross-linking versus conventional management for keratoconus: a lifetime economic model Open
Keratoconus is a progressive and life-altering disease with substantial clinical, economic, and humanistic consequences. The economic value of cross-linking is maximized when applied earlier in the disease process and/or younger age, and e…
View article: Patient and caregiver benefit‐risk preferences for nonmetastatic castration‐resistant prostate cancer treatment
Patient and caregiver benefit‐risk preferences for nonmetastatic castration‐resistant prostate cancer treatment Open
Background Recently approved second‐generation androgen receptor inhibitors (SGARIs) for non‐metastatic castration‐resistant prostate cancer (nmCRPC) have similar efficacy but differ in safety profiles. We used a discrete choice experiment…
View article: Physician preferences for non-metastatic castration-resistant prostate cancer treatment
Physician preferences for non-metastatic castration-resistant prostate cancer treatment Open
View article: Nomogram for Estimating Overall Survival in Patients With Metastatic Pancreatic Cancer
Nomogram for Estimating Overall Survival in Patients With Metastatic Pancreatic Cancer Open
Objectives This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. Methods Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) ( nab -paclitaxel …
View article: The Real-World Lifetime Economic Burden of Urothelial Carcinoma by Stage at Diagnosis.
The Real-World Lifetime Economic Burden of Urothelial Carcinoma by Stage at Diagnosis. Open
UC continues to be a costly cancer with stage III patients having highest lifetime costs. Hospitalizations drive most of the lifetime costs across all stages; most of these hospitalizations did not involve costs related to cystectomy. Trea…
View article: Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy
Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy Open
View article: Landscape of Health-Related Quality of Life in Patients With Early-Stage Pancreatic Cancer Receiving Adjuvant or Neoadjuvant Chemotherapy
Landscape of Health-Related Quality of Life in Patients With Early-Stage Pancreatic Cancer Receiving Adjuvant or Neoadjuvant Chemotherapy Open
Objectives Pancreatic resection is associated with postoperative morbidity and reduced quality of life (QoL). A systematic literature review was conducted to understand the patient-reported outcome measure (PROM) landscape in early-stage p…
View article: Real-world incidence and burden of adverse events among non-metastatic prostate cancer patients treated with secondary hormonal therapies following androgen deprivation therapy
Real-world incidence and burden of adverse events among non-metastatic prostate cancer patients treated with secondary hormonal therapies following androgen deprivation therapy Open
Aims: To describe the incidence and identify prognostic factors of central nervous system (CNS) adverse events (AEs) and any AEs (CNS, skin rash, or fracture) and evaluate the healthcare resource utilization (HCRU), direct medical c…
View article: A Canadian Cost-Utility Analysis of 2 Trabecular Microbypass Stents at Time of Cataract Surgery in Patients with Mild to Moderate Open-Angle Glaucoma
A Canadian Cost-Utility Analysis of 2 Trabecular Microbypass Stents at Time of Cataract Surgery in Patients with Mild to Moderate Open-Angle Glaucoma Open
iStent Inject TBS implantation during cataract surgery seems to be cost effective for reducing IOP in patients with mild to moderate OAG versus cataract surgery alone.
View article: Treatment Characteristics for Nonmetastatic Castration-Resistant Prostate Cancer in the United States, Europe and Japan
Treatment Characteristics for Nonmetastatic Castration-Resistant Prostate Cancer in the United States, Europe and Japan Open
Aim: We conducted this study to describe nonmetastatic castration-resistant prostate cancer (nmCRPC) patient characteristics and treatment patterns in the US, Europe and Japan. Materials & methods: Descriptive analyses were conducted using…
View article: Survival, costs, and health care resource use by line of therapy in US Medicare patients with newly diagnosed glioblastoma: a retrospective observational study
Survival, costs, and health care resource use by line of therapy in US Medicare patients with newly diagnosed glioblastoma: a retrospective observational study Open
Background Glioblastoma (GBM) is associated with poor prognosis, large morbidity burden, and limited treatment options. This analysis evaluated real-world treatment patterns, overall survival, resource use, and costs among Medicare patient…
View article: Cost-effectiveness of a fixed combination of netupitant and palonosetron (NEPA) relative to aprepitant plus granisetron (APR + GRAN) for prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a trial-based analysis
Cost-effectiveness of a fixed combination of netupitant and palonosetron (NEPA) relative to aprepitant plus granisetron (APR + GRAN) for prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a trial-based analysis Open
This first-ever economic analysis using patient-level data from a phase 3 trial comparing neurokinin-1 receptor antagonist (NK1 RA) antiemetic regimens suggests that NEPA is highly cost-effective (and in fact cost-saving) versus an aprepit…
View article: PB1782 TWO‐YEAR SURVIVAL WITH AXICABTAGENE CILOLEUCEL IN RELAPSED OR REFRACTORY LARGE B‐CELL LYMPHOMA: AN UPDATED ANALYSIS
PB1782 TWO‐YEAR SURVIVAL WITH AXICABTAGENE CILOLEUCEL IN RELAPSED OR REFRACTORY LARGE B‐CELL LYMPHOMA: AN UPDATED ANALYSIS Open
Background: Relapsed/refractory large B cell lymphoma is historically associated with a poor prognosis, with a median overall survival (OS) of 6.3 months. In the 2‐year update of the ZUMA‐1 trial of axicabtagene ciloleucel (axi‐cel), media…
View article: A Quality-adjusted Time Without Symptoms or Toxicity (Q-TWiST) Analysis of Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma (aRCC)
A Quality-adjusted Time Without Symptoms or Toxicity (Q-TWiST) Analysis of Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma (aRCC) Open
View article: Long-term Assessment of Healthcare Utilization 5 Years After Respiratory Syncytial Virus Infection in US Infants
Long-term Assessment of Healthcare Utilization 5 Years After Respiratory Syncytial Virus Infection in US Infants Open
Background Respiratory syncytial virus (RSV) is the primary cause of respiratory tract infections in infants; however, current burden estimates report only the short-term effects of acute infection. Methods Infants with RSV infection and ≥…
View article: Budget impact of netupitant/palonosetron for the prevention of chemotherapy-induced nausea and vomiting
Budget impact of netupitant/palonosetron for the prevention of chemotherapy-induced nausea and vomiting Open
Background: Chemotherapy-induced nausea and vomiting (CINV) are among the most common and debilitating side-effects patients experience during chemotherapy, and are associated with considerable acute care use and healthcare cost. It…
View article: PCN156 CHARACTERISTICS AND TREATMENT PATTERNS FOR NON-METASTATIC CASTRATION RESISTANT PROSTATE CANCER (NMCRPC) PATIENTS IN GERMANY, FRANCE, AND UNITED KINGDOM (UK)
PCN156 CHARACTERISTICS AND TREATMENT PATTERNS FOR NON-METASTATIC CASTRATION RESISTANT PROSTATE CANCER (NMCRPC) PATIENTS IN GERMANY, FRANCE, AND UNITED KINGDOM (UK) Open
View article: PRO69 PATIENT AND CAREGIVER PREFERENCES FOR CHARACTERISTICS OF TREATMENT IN HEMOPHILIA A: LITERATURE REVIEW AND QUALITATIVE RESEARCH
PRO69 PATIENT AND CAREGIVER PREFERENCES FOR CHARACTERISTICS OF TREATMENT IN HEMOPHILIA A: LITERATURE REVIEW AND QUALITATIVE RESEARCH Open
View article: MS2 AN UPDATED TWO-YEAR SURVIVAL ANALYSIS OF AXICABTAGENE CILOLEUCEL (AXI-CEL) IN RELAPSED OR REFRACTORY LARGE B-CELL LYMPHOMA (R/R-LBCL)
MS2 AN UPDATED TWO-YEAR SURVIVAL ANALYSIS OF AXICABTAGENE CILOLEUCEL (AXI-CEL) IN RELAPSED OR REFRACTORY LARGE B-CELL LYMPHOMA (R/R-LBCL) Open
View article: PNS54 SYSTEMATIC REVIEW AND BENCHMARKING OF US BUDGET IMPACT ANALYSES
PNS54 SYSTEMATIC REVIEW AND BENCHMARKING OF US BUDGET IMPACT ANALYSES Open
View article: Economic-Burden Trajectories in Commercially Insured US Infants With Respiratory Syncytial Virus Infection
Economic-Burden Trajectories in Commercially Insured US Infants With Respiratory Syncytial Virus Infection Open
The RSV burden extends across cost domains and prematurity, with the greatest burden incurred by the second year of follow-up. Findings are useful in determining the cost-effectiveness of RSV therapies in development.