Marc Delord
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View article: Erratum to “Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial” [J Infect 91 (2025) 106504]
Erratum to “Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial” [J Infect 91 (2025) 106504] Open
The publisher regrets that an error was made with the upload of the supplementary material. The CONSORT 2010 checklist page numbering is incorrect and relates to a previous typesetting of the article. A revised document correcting the page…
View article: Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial
Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial Open
Progression to a substantive trial is feasible with modifications to the existing FERARO protocol. FMT was safe, well tolerated, and acceptable to patients colonised with MDRO. Microbiome analysis infers that greater donor-recipient microb…
View article: The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT
The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT Open
Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejec…
View article: Statin Therapy and Stroke Risk in Patients with Hypercholesterolaemia: A population-based Longitudinal Study Using Electronic Health Records in South London
Statin Therapy and Stroke Risk in Patients with Hypercholesterolaemia: A population-based Longitudinal Study Using Electronic Health Records in South London Open
Background We aim to evaluate the impact of statin prescription on stroke risk in patients with hypercholesterolaemia and to assess disparities in statin prescribing. Methods We analysed electronic health records from patients with hyperch…
View article: Multicentre, multi-arm, double-blind randomised placebo-controlled dose-finding trial investigating the safety and Efficacy of MirococePt (APT070) In Reducing delayed graft function In the Kidney ALlograft (EMPIRIKAL-2): study protocol for a randomised controlled trial
Multicentre, multi-arm, double-blind randomised placebo-controlled dose-finding trial investigating the safety and Efficacy of MirococePt (APT070) In Reducing delayed graft function In the Kidney ALlograft (EMPIRIKAL-2): study protocol for a randomised controlled trial Open
Background Up to 50% of kidney transplant patients are diagnosed with delayed graft function (DGF) following transplantation—the majority being linked to ischaemia reperfusion injury (IRI). DGF is traditionally defined as the requirement f…
View article: Multiple states clustering analysis (MSCA), an unsupervised approach to multiple time-to-event electronic health records applied to multimorbidity associated with myocardial infarction
Multiple states clustering analysis (MSCA), an unsupervised approach to multiple time-to-event electronic health records applied to multimorbidity associated with myocardial infarction Open
View article: Patient-oriented unsupervised learning to uncover the patterns of multimorbidity associated with stroke using primary care electronic health records
Patient-oriented unsupervised learning to uncover the patterns of multimorbidity associated with stroke using primary care electronic health records Open
View article: Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression
Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression Open
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneou…
View article: Does Ethnicity Alter the Hazard of Stroke in Patients with Major Modifiable Cardiometabolic Risk Factors? A population-based Longitudinal Study using Electronic Health Records in South London
Does Ethnicity Alter the Hazard of Stroke in Patients with Major Modifiable Cardiometabolic Risk Factors? A population-based Longitudinal Study using Electronic Health Records in South London Open
Background Ethnic inequality in stroke risk was partially explained by a history of hypertension, diabetes and socioeconomic status. We aimed to estimate the impact of ethnicity on the hazard of stroke in patients with hypertension, diabet…
View article: Patient-Oriented Unsupervised Learning to Unlock Patterns of Multimorbidity Associated with Stroke using Primary Care Electronic Health Records
Patient-Oriented Unsupervised Learning to Unlock Patterns of Multimorbidity Associated with Stroke using Primary Care Electronic Health Records Open
Background: Identifying and characterising the longitudinal patterns of multimorbidity associated with stroke is needed to better understand patients' needs and inform new models of care. Methods: We used an unsupervised patient-oriented c…
View article: Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation
Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation Open
View article: 293. Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organism: a prospective, randomised placebo-controlled feasibility trial - The FERARO study (IRCTN reg. no. 34467677)
293. Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organism: a prospective, randomised placebo-controlled feasibility trial - The FERARO study (IRCTN reg. no. 34467677) Open
Background The gastrointestinal tract (GIT) is a reservoir of antibiotic resistant organisms (ARO). ARO colonisation precedes infections which are more challenging to treat than if drug susceptible, with excess morbidity and mortality. Pre…
View article: Long-term heart function in cardiac-arrest survivors
Long-term heart function in cardiac-arrest survivors Open
View article: Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation
Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation Open
View article: Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)—An open-label, single-arm Simon’s two stage phase 1 study protocol
Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)—An open-label, single-arm Simon’s two stage phase 1 study protocol Open
Background Pediatric acute liver failure (PALF) carries a high mortality without liver transplantation (LT) in children. Liver transplantation, though lifesaving, is limited by timely donor organ availability, the risks of major surgery an…
View article: Unsupervised Clustering Approach to Multiple Time-to-Event Electronic Health Records applied to Multimorbidity associated with Myocardial Infarction
Unsupervised Clustering Approach to Multiple Time-to-Event Electronic Health Records applied to Multimorbidity associated with Myocardial Infarction Open
Multimorbidity is characterized by the accrual of two or more long-term conditions (LTCs) in an individual. This state of health is increasingly prevalent and poses public health challenges. Adapting approaches to effectively analyse elect…
View article: Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study
Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study Open
Background Locally advanced/recurrent head and neck squamous cell carcinoma (HNSCC) is associated with significant morbidity and mortality. To target upregulated ErbB dimer expression in this cancer, we developed an autologous CD28-based c…
View article: CXCR4 signaling strength regulates hematopoietic multipotent progenitor fate through extrinsic and intrinsic mechanisms
CXCR4 signaling strength regulates hematopoietic multipotent progenitor fate through extrinsic and intrinsic mechanisms Open
How cell-extrinsic niche-related and cell-intrinsic cues drive lineage specification of hematopoietic multipotent progenitors (MPPs) in the bone marrow (BM) is partly understood. We show that CXCR4 signaling strength regulates localization…
View article: Table S4 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Table S4 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Differentially translated transcripts - translatome
View article: Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Deletion of chromosome 6q is a well-recognized abnormality found in poor-prognosis T-cell acute lymphoblastic leukemia (T-ALL). Using integrated genomic approaches, we identified two candidate haploinsufficient genes contiguous at 6q14,
View article: Table S5 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Table S5 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Differentially expressed genes in Xenograted T-ALL shSYNCRIP-SNHG5 versus ShCtrl
View article: Supplementary Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Supplementary Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Supp Fig. S1-6, Supp Tables S1-S3, Supp Methods and References
View article: Table S4 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Table S4 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Differentially translated transcripts - translatome
View article: Supplementary Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Supplementary Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Supp Fig. S1-6, Supp Tables S1-S3, Supp Methods and References
View article: Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Deletion of chromosome 6q is a well-recognized abnormality found in poor-prognosis T-cell acute lymphoblastic leukemia (T-ALL). Using integrated genomic approaches, we identified two candidate haploinsufficient genes contiguous at 6q14,
View article: Table S3 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Table S3 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Differentially Expressed Proteins Deleted versus non-deleted clones
View article: Table S3 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Table S3 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Differentially Expressed Proteins Deleted versus non-deleted clones
View article: Table S5 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
Table S5 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation Open
Differentially expressed genes in Xenograted T-ALL shSYNCRIP-SNHG5 versus ShCtrl
View article: Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma
Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma Open
Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma
View article: Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma
Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma Open
Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma