Marc Dhénain
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View article: Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline
Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline Open
View article: Vers l’utilisation des pseudo-prions contre les maladies neurodégénératives
Vers l’utilisation des pseudo-prions contre les maladies neurodégénératives Open
International audience
View article: Normal aging increases white matter microglial reaction and perivascular macrophages in the microcebe primate
Normal aging increases white matter microglial reaction and perivascular macrophages in the microcebe primate Open
As populations age, the incidence of neurodegenerative disorders is rising. Early age-related neuropathological changes are the breeding ground for the development of these disorders. Microglia are the resident macrophages of the central n…
View article: Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus
Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus Open
Resveratrol (RSV), a polyphenol with anti-aging properties affecting metabolism and energy balance, is considered as a mimetic candidate to calorie restriction (CR). However its potential effects on delaying the onset of age-related diseas…
View article: Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits
Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits Open
DCLK3 (Doublecortin-like kinase 3) is a kinase preferentially expressed in neurons. Dclk3 variants are risk factors for psychiatric disorders and brain alterations linked to age-related mild cognitive impairment, suggesting that this kinas…
View article: Contributions of connectional pathways to shaping Alzheimer’s disease pathologies
Contributions of connectional pathways to shaping Alzheimer’s disease pathologies Open
Four important imaging biomarkers of Alzheimer’s disease, namely grey matter atrophy, glucose hypometabolism and amyloid-β and tau deposition, follow stereotypical spatial distributions shaped by the brain network of structural and functio…
View article: Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization
Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization Open
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying …
View article: Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model
Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model Open
View article: Etude comparative des reseaux cerebraux en IRM fonctionnelle au repos chez l’humain, le microcebe et la souris
Etude comparative des reseaux cerebraux en IRM fonctionnelle au repos chez l’humain, le microcebe et la souris Open
Les réseaux cérébraux au repos, visibles en IRM fonctionnelle, sont les reflets de l’activité intrinsèque du cerveau et donnent de précieuses informations sur la fonction cérébrale saine et pathologique. L’étude de ces réseaux dans des mod…
View article: Organisation et bilan d’activité des comités d’éthique en expérimentation animale (CEEA) : enseignements sur des pistes d’évolution
Organisation et bilan d’activité des comités d’éthique en expérimentation animale (CEEA) : enseignements sur des pistes d’évolution Open
Les comités d’éthique en expérimentation animale (CEEA) sont les structures officiellement responsables de l’évaluation des projets expérimentaux impliquant l’utilisation d’animaux vivants, l’autorisation des projets étant ensuite délivrée…
View article: Mean amplitude of low frequency fluctuations measured by fMRI at 11.7 T in the aging brain of mouse lemur primate
Mean amplitude of low frequency fluctuations measured by fMRI at 11.7 T in the aging brain of mouse lemur primate Open
View article: Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation
Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation Open
Alzheimer’s disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins induce synaptic dysfunctions that are strongly correlat…
View article: Intrahippocampal Inoculation of Aβ1–42 Peptide in Rat as a Model of Alzheimer’s Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells
Intrahippocampal Inoculation of Aβ1–42 Peptide in Rat as a Model of Alzheimer’s Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells Open
Circulating microRNAs (miRNAs) have aroused a lot of interest as reliable blood diagnostic biomarkers of Alzheimer’s disease (AD). Here, we investigated the panel of expressed blood miRNAs in response to aggregated Aβ1–42 peptides infused …
View article: Recherche fondamentale et préclinique en neuro-psycho-pharmacologie : réflexion sur les tests comportementaux
Recherche fondamentale et préclinique en neuro-psycho-pharmacologie : réflexion sur les tests comportementaux Open
Dépression, modèles animaux, tests comportementaux
View article: Recherche fondamentale et préclinique en neuro-psychopharmacologie : réflexion sur les tests comportementaux
Recherche fondamentale et préclinique en neuro-psychopharmacologie : réflexion sur les tests comportementaux Open
View article: Mean amplitude of low frequency fluctuations measured by fMRI at 11.7T in the aging brain of mouse lemur primate
Mean amplitude of low frequency fluctuations measured by fMRI at 11.7T in the aging brain of mouse lemur primate Open
Non-human primates are a critical species for the identification of key biological mechanisms in normal and pathological aging. One of these primates, the mouse lemur, has been widely studied as a model of cerebral aging or Alzheimer’s dis…
View article: Long term worsening of Alzheimer pathology and clinical outcome by a single inoculation of mutated beta-amyloid seeds
Long term worsening of Alzheimer pathology and clinical outcome by a single inoculation of mutated beta-amyloid seeds Open
Background Alzheimer’s disease (AD) is characterized by intracerebral accumulation of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These lesions induce synaptic dysfunctions that are strongly correlate…
View article: Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice Open
Alzheimer's disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Three types of tau lesions occur in the form of neuropil threads, ne…
View article: An evolutionary gap in primate default mode network organization
An evolutionary gap in primate default mode network organization Open
View article: Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations
Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations Open
Pathogenesis of the inherited neurodegenerative disorder Huntington’s disease (HD) is progressive with a long presymptomatic phase in which subtle changes occur up to 15 years before the onset of symptoms. Thus, there is a need for early, …
View article: Whole brain mapping of glutamate distribution in adult and old primates at 11.7T
Whole brain mapping of glutamate distribution in adult and old primates at 11.7T Open
Glutamate is the amino acid with the highest cerebral concentration. It plays a central role in brain metabolism. It is also the principal excitatory neurotransmitter in the brain and is involved in multiple cognitive functions. Alteration…
View article: Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate Open
View article: Whole brain mapping of glutamate in adult and old primates at 11.7T
Whole brain mapping of glutamate in adult and old primates at 11.7T Open
Glutamate is the amino acid with the highest cerebral concentration. It plays a central role in brain metabolism. It is also the principal excitatory neurotransmitter in the brain and is involved in multiple cognitive functions. Alteration…
View article: Identification of the key role of white matter alteration in the pathogenesis of Huntington’s Disease
Identification of the key role of white matter alteration in the pathogenesis of Huntington’s Disease Open
Pathogenesis of the inherited neurodegenerative disorder Huntington’s Disease (HD) is complex and progressive, with a long presymptomatic phase in which subtle changes occur in the brain of gene carriers up to 15 years before the onset of …
View article: Transmission iatrogène des protéines β-amyloïde et tau : importance clinique et pour la recherche biomédicale sur la maladie d’Alzheimer
Transmission iatrogène des protéines β-amyloïde et tau : importance clinique et pour la recherche biomédicale sur la maladie d’Alzheimer Open
View article: Zero Echo Time 17O-MRI Reveals Decreased Cerebral Metabolic Rate of Oxygen Consumption in a Murine Model of Amyloidosis
Zero Echo Time 17O-MRI Reveals Decreased Cerebral Metabolic Rate of Oxygen Consumption in a Murine Model of Amyloidosis Open
The cerebral metabolic rate of oxygen consumption (CMRO2) is a key metric to investigate the mechanisms involved in neurodegeneration in animal models and evaluate potential new therapies. CMRO2 can be measured by direct 17O magnetic reson…
View article: Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice Open
Alzheimer’s disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Tau lesions occur in the form of neuropil threads, neurofibrillary t…
View article: Contribution de la Cellule Covid 19 de l'Académie Vétérinaire de France : Bilan provisoire et perspectives
Contribution de la Cellule Covid 19 de l'Académie Vétérinaire de France : Bilan provisoire et perspectives Open
La cellule Covid-19 de l'Académie vétérinaire de France a été créée au lendemain de la mise en place du premier confinement lors de la pandémie de 2020 liée au coronavirus SARS-CoV-2. Cette cellule s'est organisée autour de quatre objectif…
View article: An Evolutionary Gap in Primate Default Mode Network Organization
An Evolutionary Gap in Primate Default Mode Network Organization Open
View article: Effect of Alzheimer’s disease‐related β‐amyloid peptide conformations in transgenic mouse models of β‐amyloidosis
Effect of Alzheimer’s disease‐related β‐amyloid peptide conformations in transgenic mouse models of β‐amyloidosis Open
Background Alzheimer’s disease (AD) brain dysfunctions are not exclusively related to amyloid plaques occurence, but are thought to start much earlier, presumably due to soluble pathological forms of b‐amyloid peptide (Aβ). Indeed Aβ oligo…