Marc‐Emmanuel Dumas
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View article: A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. Open
Cardiometabolic diseases (CMD) are on the rise globally with one billion people expected to suffer from obesity and 643 million from type 2 diabetes by 2030, of which one-third will likely develop chronic kidney disease and two-thirds will…
View article: Impact of Erythritol and Xylitol on Glucose Metabolism and Gut Microbiota in Obese Individuals: A Randomized Controlled Trial
Impact of Erythritol and Xylitol on Glucose Metabolism and Gut Microbiota in Obese Individuals: A Randomized Controlled Trial Open
Objective The aim of this study was to examine whether glucose tolerance, metabolomic profile, and gut microbiota composition is influenced by regular intake of erythritol or xylitol in non-diabetic, obese patients.Background Sugar alcohol…
View article: Whole Genome Sequencing for the Diagnosis of Rare Disorders
Whole Genome Sequencing for the Diagnosis of Rare Disorders Open
Background Whole-Genome Sequencing (WGS) and Whole-Transcriptome Sequencing (WTS) have emerged as transformative tools in the diagnosis of rare diseases with complex phenotypes. These technologies enable deep analysis of the genome and RNA…
View article: Perspectives on Outpatient Delivery of Bispecific T-Cell Engager Therapies for Multiple Myeloma
Perspectives on Outpatient Delivery of Bispecific T-Cell Engager Therapies for Multiple Myeloma Open
In the past few years, a new promising therapy, called bispecific T-cell engager (TCE), has been developed and is now available in many countries for patients with relapsed or refractory multiple myeloma. T-cell engagers are associated wit…
View article: Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease
Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease Open
View article: Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism
Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism Open
Background The microbiota is emerging as a key factor in the predisposition to insulin resistance and obesity. Objective To understand the interplay among gut microbiota and insulin sensitivity in multiple tissues. Design Integrative multi…
View article: Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
View article: Genomic attributes of airway commensal bacteria and mucosa
Genomic attributes of airway commensal bacteria and mucosa Open
View article: The Gut Microbiome Strongly Mediates the impact of Lifestyle combined variables on Cardiometabolic Phenotypes
The Gut Microbiome Strongly Mediates the impact of Lifestyle combined variables on Cardiometabolic Phenotypes Open
Individual lifestyle factors moderately impact the gut microbiome and host biology. This study explores whether their combined influence significantly alters the gut microbiome and determines the mediating role of the gut microbiome in the…
View article: Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 Open
Background While inflammatory and immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infectio…
View article: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
View article: Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity Open
View article: Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications
Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications Open
International audience
View article: International Pediatric COVID-19 Severity Over the Course of the Pandemic
International Pediatric COVID-19 Severity Over the Course of the Pandemic Open
Importance Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for COVID-19 severity in children worldwide are unclear. Objective To determine whether the dominant circulating SARS-CoV-2 variants of conce…
View article: Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease
Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease Open
View article: Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality
Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality Open
The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival.
View article: The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection Open
View article: ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 – a longitudinal cohort study
ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 – a longitudinal cohort study Open
Introduction Outcomes of traumatic brain injury (TBI) are highly variable, with cognitive and psychiatric problems often present in survivors, including an increased dementia risk in the long term. Military personnel are at an increased oc…
View article: SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination Open
View article: Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine<i>N</i>-oxide with implications for heart and kidney disorders
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine<i>N</i>-oxide with implications for heart and kidney disorders Open
Objectives The host-microbiota co-metabolite trimethylamine N -oxide (TMAO) is linked to increased thrombotic and cardiovascular risks. Here we, sought to i) characterize which host variables contribute to fasting serum TMAO levels in real…
View article: Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study Open
Background We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. …
View article: Genomic and ecologic characteristics of the airway microbial-mucosal complex
Genomic and ecologic characteristics of the airway microbial-mucosal complex Open
S ummary paragraph Lung diseases due to infection and dysbiosis affect hundreds of millions of people world-wide 1-4 . Microbial communities at the airway mucosal barrier are conserved and highly ordered 5 , reflecting symbiosis and co-evo…
View article: High Resolution Ambient MS Imaging of Biological Samples by Desorption Electro-Flow Focussing Ionization
High Resolution Ambient MS Imaging of Biological Samples by Desorption Electro-Flow Focussing Ionization Open
In this study, we examine the suitability of desorption electro-flow focusing ionization (DEFFI) for mass spectrometry imaging (MSI) of biological tissue. We also compare the performance of desorption electrospray ionization (DESI) with an…
View article: ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids
ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids Open
View article: Microbiome and metabolome features of the cardiometabolic disease spectrum
Microbiome and metabolome features of the cardiometabolic disease spectrum Open
View article: Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease Open
View article: Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism Open
Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s functional composition in healthy metabolic stat…
View article: SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses Open
View article: “You look sleepy…” The impact of sleep restriction on skin parameters and facial appearance of 24 women
“You look sleepy…” The impact of sleep restriction on skin parameters and facial appearance of 24 women Open
Two nights of SR significantly altered the skin and facial appearances in our test group of typically good-sleeping women.
View article: Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia Open