Marc Gitzinger
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View article: First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug
First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug Open
Background The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. Objectives A Phase 1, double-blind, randomized, placebo-controlled study to investigate …
View article: Targeting virulence regulation to disarm <i>Acinetobacter baumannii</i> pathogenesis
Targeting virulence regulation to disarm <i>Acinetobacter baumannii</i> pathogenesis Open
The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcript…
View article: Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration
Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration Open
View article: The small-molecule SMARt751 reverses <i>Mycobacterium tuberculosis</i> resistance to ethionamide in acute and chronic mouse models of tuberculosis
The small-molecule SMARt751 reverses <i>Mycobacterium tuberculosis</i> resistance to ethionamide in acute and chronic mouse models of tuberculosis Open
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties…
View article: Design and Synthesis of Water-Soluble Prodrugs of Rifabutin for Intraveneous Administration
Design and Synthesis of Water-Soluble Prodrugs of Rifabutin for Intraveneous Administration Open
View article: The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli
The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli Open
Gut microbiota dysbiosis toward adherent-invasive Escherichia coli (AIEC) plays an important role in Crohn’s disease (CD). The OmpR transcriptional regulator is required for the AIEC LF82 prototype strain to adhere and invade intestinal ep…
View article: <i>In vitro</i>activity of rifabutin against 293 contemporary carbapenem-resistant<i>Acinetobacter baumannii</i>clinical isolates and characterization of rifabutin mode of action and resistance mechanisms
<i>In vitro</i>activity of rifabutin against 293 contemporary carbapenem-resistant<i>Acinetobacter baumannii</i>clinical isolates and characterization of rifabutin mode of action and resistance mechanisms Open
Background Rifabutin, an oral drug approved to treat Mycobacterium avium infections, demonstrated potent activity against Acinetobacter baumannii in nutrient-limited medium enabled by rifabutin cellular uptake through the siderophore recep…
View article: Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates
Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates Open
The discovery of antibiotics revolutionized modern medicine and enabled us to cure previously deadly bacterial infections. However, a progressive increase in antibiotic resistance rates is a major and global threat for our health care syst…
View article: A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2
A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2 Open
View article: Reversion of antibiotic resistance in <i>Mycobacterium tuberculosis</i> by spiroisoxazoline SMARt-420
Reversion of antibiotic resistance in <i>Mycobacterium tuberculosis</i> by spiroisoxazoline SMARt-420 Open
Countering TB prodrug resistance The arsenal of antibiotics for treating tuberculosis (TB) contains many prodrugs, such as ethionamide, which need activation by normal metabolism to release their toxic effects. Ethionamide is potentiated b…
View article: A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism
A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism Open
Infections with the Gram-negative coccobacillus Acinetobacter baumannii are a major threat in hospital settings. The progressing emergence of multidrug-resistant clinical strains significantly reduces the treatment options for clinicians t…