Marc Hernaiz-Llorens
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View article: Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration
Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration Open
Despite substantial progress in understanding the biology of axon regeneration in the CNS, our ability to promote regeneration of the clinically important corticospinal tract (CST) after spinal cord injury remains limited. To understand re…
View article: Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion Open
Introduction Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of…
View article: Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq
Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq Open
The corticospinal tract (CST) is clinically important for the recovery of motor functions after spinal cord injury. Despite substantial progress in understanding the biology of axon regeneration in the central nervous system (CNS), our abi…
View article: New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization
New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization Open
Neuronal cell adhesion molecule 2 (NCAM2) is a membrane protein with an important role in the morphological development of neurons. In the cortex and the hippocampus, NCAM2 is essential for proper neuronal differentiation, dendritic and ax…
View article: Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion
Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion Open
Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of the cellular…
View article: One Raft to Guide Them All, and in Axon Regeneration Inhibit Them
One Raft to Guide Them All, and in Axon Regeneration Inhibit Them Open
Central nervous system damage caused by traumatic injuries, iatrogenicity due to surgical interventions, stroke and neurodegenerative diseases is one of the most prevalent reasons for physical disability worldwide. During development, axon…
View article: Author response: Olig3 regulates early cerebellar development
Author response: Olig3 regulates early cerebellar development Open
View article: Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors
Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors Open
View article: Olig3 acts as a master regulator of cerebellar development
Olig3 acts as a master regulator of cerebellar development Open
The mature cerebellum controls motor skill precision and participates in other sophisticated brain functions that include learning, cognition and speech. Different types of GABAergic and glutamatergic cerebellar neurons originate in tempor…
View article: Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide
Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide Open
Nystatin is a pharmacological agent commonly used for the treatment of oral, mucosal and cutaneous fungal infections. Nystatin has also been extensively applied to study the cellular function of cholesterol-enriched structures because of i…
View article: Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration
Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration Open
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. Cholester…
View article: A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse
A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse Open
Axonal growth and guidance rely on correct growth cone responses to guidance cues. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the crosstalk mechanisms between guidance and membrane…