Marc Hinterthaner
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View article: Proteasome inhibition as a potential therapeutic target in thymic cancer
Proteasome inhibition as a potential therapeutic target in thymic cancer Open
Multimodal radio-chemotherapy is the mainstay of treatment for unresectable thymoma (TH) and thymic carcinoma (TC), but there is an urgent need for other therapeutic strategies in these rare tumors. The epithelial cells of the normal thymu…
View article: Expression and prongostic impact of galectin-7 in human lung cancer
Expression and prongostic impact of galectin-7 in human lung cancer Open
Malignant tumors of the lung are the leading cancers worldwide. Prognostic biomarkers continue to be investigated for the detection and stratification of lung cancer for clinical use. In breast cancer cells and in lymphomas, the overexpres…
View article: Proteomic analysis identifies argininosuccinate synthetase 1 and special AT‐rich sequence binding protein 1 as reliable markers for the immunohistochemical distinction between WHO types A and B3 thymomas
Proteomic analysis identifies argininosuccinate synthetase 1 and special AT‐rich sequence binding protein 1 as reliable markers for the immunohistochemical distinction between WHO types A and B3 thymomas Open
Aims The reliable classification of type A versus type B3 thymomas has prognostic and therapeutic relevance, but can be problematic due to considerably overlapping morphology. No immunohistochemical markers aiding in this distinction have …
View article: NTRK Gene Fusions in Non-Small-Cell Lung Cancer: Real-World Screening Data of 1068 Unselected Patients
NTRK Gene Fusions in Non-Small-Cell Lung Cancer: Real-World Screening Data of 1068 Unselected Patients Open
(1) Background: The main objectives of our study are (i) to determine the prevalence of NTRK (neurotrophic tyrosine kinase) fusions in a routine diagnostic setting in NSCLC (non-small cell lung cancer) and (ii) to investigate the feasibili…
View article: Optimizing the structure of interdisciplinary tumor boards for effective cancer care
Optimizing the structure of interdisciplinary tumor boards for effective cancer care Open
Introduction Multi-professional interdisciplinary tumor boards (ITB) are essential institutions to discuss all newly diagnosed, relapsed or complex cancer patients in a team of specialists to find an optimal cancer care plan for each indiv…
View article: Expression and prognostic impact of DNA-PK in human lung cancer
Expression and prognostic impact of DNA-PK in human lung cancer Open
Among all cancer patient’s lung cancer is the leading cause of death. Prognostic biomarkers continue to be investigated for the detection and stratification of lung cancer for clinical use. The DNA-dependent protein kinase is involved in m…
View article: Phosphoproteomic Analysis Identifies TYRO3 as a Mediator of Sunitinib Resistance in Metastatic Thymomas
Phosphoproteomic Analysis Identifies TYRO3 as a Mediator of Sunitinib Resistance in Metastatic Thymomas Open
Background: After initially responding to empiric radio-chemotherapy, most advanced thymomas (TH) and thymic carcinomas (TC) become refractory and require second-line therapy. The multi-target receptor tyrosine kinase (RTK) inhibitor, suni…
View article: Regulation and Therapeutic Targeting of MTHFD2 and EZH2 in KRAS-Mutated Human Pulmonary Adenocarcinoma
Regulation and Therapeutic Targeting of MTHFD2 and EZH2 in KRAS-Mutated Human Pulmonary Adenocarcinoma Open
Activating KRAS mutations occur in about 30% of pulmonary adenocarcinoma (AC) cases and the discovery of specific inhibitors of G12C-mutated KRAS has considerably improved the prognosis for a subgroup of about 14% of non-small cell lung ca…
View article: Symptom relief, prognostic factors, and outcome in patients receiving urgent radiation therapy for superior vena cava syndrome
Symptom relief, prognostic factors, and outcome in patients receiving urgent radiation therapy for superior vena cava syndrome Open
Purpose Superior vena cava syndrome (SVCS) often results from external vessel compression due to tumor growth. Urgent symptom-guided radiotherapy (RT) remains a major treatment approach in histologically proven, rapidly progressive disease…
View article: Endoscopic Lung Volume Reduction with One-Way Valves in Patients with Severe Chronic Obstructive Pulmonary Disease with Hypercapnia
Endoscopic Lung Volume Reduction with One-Way Valves in Patients with Severe Chronic Obstructive Pulmonary Disease with Hypercapnia Open
Background: Robust clinical evidence on the efficacy and safety of endoscopic lung volume reduction (ELVR) with one-way valves in patients with severe lung emphysema with chronic hypercapnic respiratory failure is lacking.
View article: Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas
Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas Open
View article: One carbon metabolism in human lung cancer
One carbon metabolism in human lung cancer Open
Expression of MTHFD2 significantly reduces the prognosis of AC patients. Furthermore, MTHFD2 expression is crucial for survival of AC cell lines and its expression correlates with resistance against Pemetrexed. As MTHFD2 is almost not expr…
View article: Role of Annexin A1 in Squamous Cell Lung Cancer Progression
Role of Annexin A1 in Squamous Cell Lung Cancer Progression Open
Lung cancer remains the primary cause of cancer-related death worldwide, and its molecular mechanisms of tumor progression need further characterization to improve the clinical management of affected patients. The role of Annexin A1 (ANXA1…
View article: Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis
Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis Open
The newly defined top-level category of MET amplification in NSCLC defines a specific subgroup of pulmonary adenocarcinoma with adverse prognosis and characteristic morphological features. Lower levels of MET gene copy number…
View article: Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer
Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer Open
Background Targeting fibroblast growth factor receptor 1 ( FGFR1 ) is a potential treatment for squamous cell lung cancer (SQCLC). So far, treatment decision in clinical studies is based on gene amplification. However, only a minority of p…
View article: UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma
UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma Open
Background: UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels …
View article: Surgical approaches for treatment of ureteropelvic junction obstruction – a systematic review and network meta-analysis
Surgical approaches for treatment of ureteropelvic junction obstruction – a systematic review and network meta-analysis Open
View article: Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis
Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis Open
Muscle loss is an independent risk factor for increased death risk in lung cancer patients independent of cancer stage. This argues for implementing screening for sarcopenia into cancer care.
View article: Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer
Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer Open
Molecular characterization of lung cancer specimens after radical surgery offers additional prognostic information and may help to guide adjuvant therapeutic procedures. The transcriptional regulators alpha thalassemia/mental retardation X…
View article: Molecular Classification of Neuroendocrine Tumors of the Thymus
Molecular Classification of Neuroendocrine Tumors of the Thymus Open
View article: Surgical approaches for treatment of ureteropelvic junction obstruction – a systematic review and network meta-analysis
Surgical approaches for treatment of ureteropelvic junction obstruction – a systematic review and network meta-analysis Open
Background: Multiple surgical treatment options are available for the treatment of ureteropelvic junction obstruction (UPJO).The aim of this study is to compare the most frequently used technics in a comprehensive network approach.Methods:…
View article: Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis
Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis Open
View article: Thymectomy via open surgery or robotic video assisted thoracic surgery
Thymectomy via open surgery or robotic video assisted thoracic surgery Open
Patients undergoing RVATS spent less time in hospital than patients treated by open surgery (sternotomy). These patients tended to have less postoperative complications, less intraoperative blood loss, and fewer chest-in-tube days. We foun…
View article: Acute respiratory distress syndrome after aspiration of lamp oil in a fire-eater: a case report
Acute respiratory distress syndrome after aspiration of lamp oil in a fire-eater: a case report Open
View article: Comparison of Conductive and Convective Warming in Patients Undergoing Video-Assisted Thoracic Surgery: A Prospective Randomized Clinical Trial
Comparison of Conductive and Convective Warming in Patients Undergoing Video-Assisted Thoracic Surgery: A Prospective Randomized Clinical Trial Open
Background Perioperative hypothermia is frequent during thoracic surgery. After approval by the local ethics committee and written informed consent from patients, we examined the efficiency of prewarming and intraoperative warming with a c…
View article: Isolated Mediastinal Kocuria rosea Infection Mimicking Malignancies
Isolated Mediastinal Kocuria rosea Infection Mimicking Malignancies Open
Isolated mediastinal Kocuria rosea infection is a rare condition and presentation can be variable. We report an unusual case of Kocuria rosea infection which presented as solitary pulmonary nodules and isolated lymph node swelling, en…
View article: Isolated Mediastinal Kocuria rosea Infection Mimicking Malignancies
Isolated Mediastinal Kocuria rosea Infection Mimicking Malignancies Open
Isolated mediastinal Kocuria rosea infection is a rare condition and presentation can be variable. We report an unusual case of Kocuria rosea infection which presented as solitary pulmonary nodules and isolated lymph node swelling, entirel…