Marc Horner
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View article: Finite element analysis of cardiovascular stent frames: identifying appropriate mesh discretization
Finite element analysis of cardiovascular stent frames: identifying appropriate mesh discretization Open
Engineers use finite element analysis (FEA) to predict the deformations, strains, stresses, and resistive forces of metallic stent frames under in vivo , in vitro , and manufacturing-induced loading conditions. The discretization of the ge…
View article: A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare
A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare Open
The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Committee on Credible Practice of Modeling & Simu…
View article: Association of Anaemia With Higher Mortality and Disability After Subarachnoid Haemorrhage: A Single-Centre Cohort Study
Association of Anaemia With Higher Mortality and Disability After Subarachnoid Haemorrhage: A Single-Centre Cohort Study Open
View article: A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare
A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare Open
The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Committee on Credible Practice of Modeling & Simu…
View article: Model Credibility
Model Credibility Open
The need for a framework to justify that a model has sufficient credibility to be used as a basis for internal or external (typically regulatory) decision-making is a primary concern when using modelling and simulation (M&S) in healthcare.…
View article: Model Development
Model Development Open
Good Simulation Practice implies that a computational model considered for a simulation task has also been developed according to good practice.
View article: Theoretical Foundations of Good Simulation Practice
Theoretical Foundations of Good Simulation Practice Open
View article: Introduction
Introduction Open
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View article: An in silico testbed for fast and accurate MR labeling of orthopedic implants
An in silico testbed for fast and accurate MR labeling of orthopedic implants Open
One limitation on the ability to monitor health in older adults using magnetic resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: Author Response: An in silico testbed for fast and accurate MR labeling of orthopedic implants
Author Response: An in silico testbed for fast and accurate MR labeling of orthopedic implants Open
View article: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants
An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants Open
One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: Author response: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants
Author response: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants Open
One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: Author Response: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants
Author Response: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants Open
One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: Reviewer #1 (Public Review): An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants
Reviewer #1 (Public Review): An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants Open
One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: An in silico testbed for fast and accurate MR labeling of orthopedic implants
An in silico testbed for fast and accurate MR labeling of orthopedic implants Open
One limitation on the ability to monitor health in older adults using magnetic resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants
An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants Open
One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the populati…
View article: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants
An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants Open
A bstract One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in th…
View article: In Silico Fit Evaluation of Additively Manufactured Face Coverings
In Silico Fit Evaluation of Additively Manufactured Face Coverings Open
View article: Possible Contexts of Use for In Silico trials methodologies: a consensus- based review
Possible Contexts of Use for In Silico trials methodologies: a consensus- based review Open
The term In Silico Trial indicates the use of computer modelling and simulation to evaluate the safety and efficacy of a medical product, whether a drug, a medical device, a diagnostic product or an advanced therapy medicinal product. Pred…
View article: Credible practice of modeling and simulation in healthcare: ten rules from a multidisciplinary perspective
Credible practice of modeling and simulation in healthcare: ten rules from a multidisciplinary perspective Open
The complexities of modern biomedicine are rapidly increasing. Thus, modeling and simulation have become increasingly important as a strategy to understand and predict the trajectory of pathophysiology, disease genesis, and disease spread …
View article: Modeling radio-frequency energy-induced heating due to the presence of transcranial electric stimulation setup at 3T
Modeling radio-frequency energy-induced heating due to the presence of transcranial electric stimulation setup at 3T Open
Purpose The purpose of the present study was to develop a numerical workflow for simulating temperature increase in a high-resolution human head and torso model positioned in a whole-body magnetic resonance imaging (MRI) radio-frequency (R…
View article: In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products
In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products Open
View article: Toward Estimating the Uncertainty Associated With Three-Dimensional Geometry Reconstructed From Medical Image Data
Toward Estimating the Uncertainty Associated With Three-Dimensional Geometry Reconstructed From Medical Image Data Open
Patient-specific computational modeling is increasingly used to assist with visualization, planning, and execution of medical treatments. This trend is placing more reliance on medical imaging to provide accurate representations of anatomi…
View article: Modeling radiofrequency responses of realistic multi-electrode leads containing helical and straight wires
Modeling radiofrequency responses of realistic multi-electrode leads containing helical and straight wires Open
Purpose To present a modeling workflow for the evaluation of a lead electromagnetic model (LEM) consisting of a transfer function (TF) and a calibration factor. The LEM represents an analytical relationship between the RF response of a lea…
View article: Patient-Specific RF Safety Assessment in MRI: Progress in Creating Surface-Based Human Head and Shoulder Models
Patient-Specific RF Safety Assessment in MRI: Progress in Creating Surface-Based Human Head and Shoulder Models Open
The interaction of electromagnetic (EM) fields with the human body during magnetic resonance imaging (MRI) is complex and subject specific. MRI radiofrequency (RF) coil performance and safety assessment typically includes numerical EM simu…
View article: Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience
Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience Open
Modeling and simulation in computational neuroscience is currently a research enterprise to better understand neural systems. It is not yet directly applicable to the problems of patients with brain disease. To be used for clinical applica…
View article: ASME V&V40 Industry Day 2018 -- Industry and FDA Slides for Public Distribution
ASME V&V40 Industry Day 2018 -- Industry and FDA Slides for Public Distribution Open
The upcoming publication of the new ASME Standard V&V 40 -- Assessing Credibility of Computational Modeling and Simulation Results through Verification and Validation: Application to Medical Devices was a key topic at the 2018 V&V Symposiu…
View article: A uniform‐shear rate microfluidic bioreactor for real‐time study of proplatelet formation and rapidly‐released platelets
A uniform‐shear rate microfluidic bioreactor for real‐time study of proplatelet formation and rapidly‐released platelets Open
Platelet transfusions, with profound clinical importance in blood clotting and wound healing, are entirely derived from human volunteer donors. Hospitals rely on a steady supply of donations, but these methods are limited by a 5‐day shelf …
View article: Use of the FDA nozzle model to illustrate validation techniques in computational fluid dynamics (CFD) simulations
Use of the FDA nozzle model to illustrate validation techniques in computational fluid dynamics (CFD) simulations Open
A "credible" computational fluid dynamics (CFD) model has the potential to provide a meaningful evaluation of safety in medical devices. One major challenge in establishing "model credibility" is to determine the required degree of similar…