Explanipedia

SUN-033 Exploring Associations Between Stress and the Vaginal Microbiome in Healthy Young Females Open

Alice Zhang, Jyontika Kapoor, Christen M. Deveney, Adela G. Cope, Marina Walther-António , et al. · 2025

Disclosure: A. Zhang: None. J. Kapoor: None. C. Deveney: None. A.G. Cope: None. M.M. Walther-Antonio: None. N. Chia: None. C.W. Pattanayak: None. M.J. Tetel: None. The vaginal microbiome (VM) consists of the microorganisms and their metabo…

3C. 3-Ketosteroid receptors in GtoPdb v.2025.3 Open

Derek W. Cain, Nancy L. Weigel, Marc J. Tetel, Carol A. Sartorius, Jennifer K. Richer , et al. · 2025

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 221, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids …

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023 Open

Thomas P. Burris, Ian Mitchelle S. de Vera, Isabelle Côté, Colin A. Flaveny, Udayanga Wanninayake , et al. · 2023

3C. 3-Ketosteroid receptors in GtoPdb v.2023.1 Open

Derek W. Cain, John A. Cidlowski, Dean P. Edwards, Peter J. Fuller, Sandra L. Grimm , et al. · 2023

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 218, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids …

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice Open

Kalpana D. Acharya, Madeline Graham, Harshini Raman, Abigail E. R. Parakoyi, Alexis Corcoran , et al. · 2023

Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet Open

Kalpana D. Acharya, Randall H. Friedline, Doyle V. Ward, Madeline Graham, LAUREN A. TAUER , et al. · 2022

Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet…

3C. 3-Ketosteroid receptors in GtoPdb v.2021.3 Open

Derek W. Cain, John A. Cidlowski, Dean P. Edwards, Peter J. Fuller, Sandra L. Grimm , et al. · 2021

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [74, 215, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids …

Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice Open

Kalpana D. Acharya, Hye Lim Noh, Madeline Graham, Sujin Suk, Randall H. Friedline , et al. · 2021

A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain, cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that gut microbiota regulates energy homeostasis, it is unclear…

Gut and vaginal microbiomes on steroids: implications for women’s health Open

Madeline Graham, William G. Herbert, Stephanie Song, Harshini Raman, Jade E. Zhu , et al. · 2021

Author Correction: Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice Open

Kalpana D. Acharya, Xing Gao, Elizabeth P. Bless, Jun Chen, Marc J. Tetel · 2021

Dopamine‐induced interactions of female mouse hypothalamic proteins with progestin receptor‐A in the absence of hormone Open

Kalpana D. Acharya, Sabin A. Nettles, Cheryl F. Lichti, Katherine Warre‐Cornish, Lucia Dutan Polit , et al. · 2020

Neural progestin receptors (PR) function in reproduction, neural development, neuroprotection, learning, memory and the anxiety response. In the absence of progestins, PR can be activated by dopamine (DA) in the rodent hypothalamus to elic…

Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise Open

Stephanie Song, Kalpana D. Acharya, Jade E. Zhu, Christen M. Deveney, Marina Walther-António , et al. · 2020

The vaginal microbiome is a critical component of women’s sexual and reproductive health, with variations in microbial composition, particularly the loss of Lactobacillus species, being implicated in gynecologic and obstetric diseases. Giv…

Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice Open

Kalpana D. Acharya, Xing Gao, Elizabeth P. Bless, Jun Chen, Marc J. Tetel · 2019

Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and …

3C. 3-Ketosteroid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open

Derek W. Cain, John A. Cidlowski, Dean P. Edwards, Peter J. Fuller, Sandra L. Grimm , et al. · 2019

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [65, 193]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (es…

Estradiol modulates gut microbiota in female<i>ob/ob</i>mice fed a high fat diet Open

Kalpana D. Acharya, Xing Gao, Elizabeth P. Bless, Jun Chen, Marc J. Tetel · 2019

Estrogens protect against diet-induced obesity in women and female rodents. In support of these anorectic effects, lack of estrogens in postmenopausal women is associated with weight gain, increasing their risk for cardiovascular diseases …

SUN-474 Estradiol Protects Against High-Fat Diet-Induced Obesity and Anxiety in Female Mice Open

Madeline Graham, Kalpana D. Acharya, Abigail E. R. Parakoyi, Alexis Corcoran, Srikanth Gottipati , et al. · 2019

Menopause is characterized by a decline in ovarian function and a decrease in estrogens. This decrease in estrogens leads to changes in metabolic phenotype, increasing the risk of weight gain from fat, metabolic syndrome, and type 2 diabet…

SUN-198 Vaginal Microbial Diversity Changes across the Menstrual Cycle in Healthy Young Women Open

Stephanie Song, Kalpana D. Acharya, Jade E. Zhu, Marina Walther-António, Marc J. Tetel , et al. · 2019

The vaginal microbiome, the collection of microorganisms and their metabolites residing in the vaginal tract, is critical for maintaining women’s health. For example, the vaginal microbiome protects against pathogens by maintaining a low-p…

SUN-092 Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice Open

Kalpana D. Acharya, Madeline Graham, Hye Lim Noh, Sujin Suk, Randall H. Friedline , et al. · 2019

Due to an aging-associated decrease in ovarian estrogens, postmenopausal women tend to gain weight, which predisposes them to developing cardiovascular disease, type 2 diabetes, chronic inflammation, and cancer. Estradiol replacement has b…

Steroids, stress and the gut microbiome‐brain axis Open

Marc J. Tetel, Geert J. De Vries, Roberto Cosimo Melcangi, Giancarlo Panzica, Siobhain M. O’Mahony · 2017

It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota and, in turn, how the gut microbiota can influence hormone …

The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent Open

Kalpana D. Acharya, Sabin A. Nettles, Katherine J. Sellers, Dana D. Im, Moriah Harling , et al. · 2017

Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In th…

Adult Neurogenesis in the Female Mouse Hypothalamus: Estradiol and High-Fat Diet Alter the Generation of Newborn Neurons Expressing Estrogen Receptor α Open

Elizabeth P. Bless, Jane Yang, Kalpana D. Acharya, Sabin A. Nettles, Fair M. Vassoler , et al. · 2016

Estrogens and leptins act in the hypothalamus to maintain reproduction and energy homeostasis. Neurogenesis in the adult mammalian hypothalamus has been implicated in the regulation of energy homeostasis. Recently, high-fat diet (HFD) and …

Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus Open

Kalpana D. Acharya, Sarah Finkelstein, Elizabeth P. Bless, Sabin A. Nettles, Biserka Mulac‐Jeričević , et al. · 2015

Estrogens act in brain to profoundly influence neurogenesis, sexual differentiation, neuroprotection, cognition, energy homeostasis, and female reproductive behavior and physiology through a variety of mechanisms, including the induction o…

Neuroactive steroids and the peripheral nervous system: An update Open

Silvia Giatti, Simone Romano, Marzia Pesaresi, Gaia Cermenati, Nico Mitro , et al. · 2015

The 2014 FUN Achievement Award. Open

Barbara S. Beltz, Jeanne L. Benton, Bevil R. Conway, Bruce R. Johnson, Virginia Quinan , et al. · 2015

The JUNE edition of the FUN 2014 Workshop Proceedings at Ithaca College in 2014 is dedicated to Carol Ann Paul, who died in October 2014. The following provides background on her career achievements as a neuroscience educator, and is based…

Marc J. Tetel YOU? Author Swipe