Marc Kermorgant
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View article: Development and Feasibility of a Mixed Virtual and in‐Presence Therapeutic Education Program for Early Multiple System Atrophy Patients
Development and Feasibility of a Mixed Virtual and in‐Presence Therapeutic Education Program for Early Multiple System Atrophy Patients Open
Background Multiple system atrophy (MSA) is a relentlessly progressive neurodegenerative disorder with no cure. While therapeutic education programs (TEPs) benefit many chronic conditions, data in MSA are limited. Objectives To assess the …
View article: Structural Alterations Associated With Cardiovascular Autonomic Failure in Multiple System Atrophy
Structural Alterations Associated With Cardiovascular Autonomic Failure in Multiple System Atrophy Open
Background Early severe autonomic failure (AF) in multiple system atrophy (MSA) is a risk factor for poor survival. Postmortem studies suggested that AF is related to the degeneration of preganglionic autonomic neurons of the brainstem and…
View article: The Effects of Antioxidant Cocktail on Ophthalmological Changes Induced by a 60-Day Head-Down Bed Rest in a Randomized Trial
The Effects of Antioxidant Cocktail on Ophthalmological Changes Induced by a 60-Day Head-Down Bed Rest in a Randomized Trial Open
Neuro-ophthalmological changes have been reported after prolonged exposure to microgravity; however, the pathophysiology remains unclear. Furthermore, several countermeasures have been suggested to counteract the side effects of microgravi…
View article: Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions
Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions Open
Background and purpose White matter lesions (WMLs) are frequent in sickle cell disease (SCD), with a prevalence described to be as high as 53% by age 30. Cerebrovascular regulation and cardiovascular autonomic regulation, more specifically…
View article: Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions
Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions Open
Background The prevalence of asymptomatic white matter lesions (WML) in patients with sickle cell disease (SCD) has been described to be very frequent in young adults. Cerebrovascular regulation and cardiovascular autonomic regulation, mor…
View article: Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight Open
Whether in real or simulated microgravity, Humans or animals, the kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial. In this study, we used hindlimb unloading (HU) in 10 con…
View article: Age and Gender Differences in Cardiovascular Autonomic Failure in the Transgenic PLP-syn Mouse, a Model of Multiple System Atrophy
Age and Gender Differences in Cardiovascular Autonomic Failure in the Transgenic PLP-syn Mouse, a Model of Multiple System Atrophy Open
Multiple system atrophy (MSA) is a rare and progressive neurodegenerative disorder. Autonomic failure (AF) is one main clinical feature which has a significant impact on health-related quality of life. The neuropathological hallmark of MSA…
View article: Reduced Regional Cerebral Blood Flow Measured by 99mTc-Hexamethyl Propylene Amine Oxime Single-Photon Emission Computed Tomography in Microgravity Simulated by 5-Day Dry Immersion
Reduced Regional Cerebral Blood Flow Measured by 99mTc-Hexamethyl Propylene Amine Oxime Single-Photon Emission Computed Tomography in Microgravity Simulated by 5-Day Dry Immersion Open
Microgravity induces a cephalad fluid shift that is responsible for cephalic venous stasis that may increase intracranial pressure (ICP) in astronauts. However, the effects of microgravity on regional cerebral blood flow (rCBF) are not kno…
View article: Effects of Resistance Exercise with or without Whey Protein Supplementation on Ocular Changes after a 21-Day Head-Down Bed Rest
Effects of Resistance Exercise with or without Whey Protein Supplementation on Ocular Changes after a 21-Day Head-Down Bed Rest Open
Neuro-ophthalmological changes have been reported after prolonged exposure to microgravity; however, the pathophysiology remains unclear. The objectives of the present study were twofold: (1) to assess the neuro-ophthalmological impact of …
View article: Effects of Venoconstrictive Thigh Cuffs on Dry Immersion-Induced Ophthalmological Changes
Effects of Venoconstrictive Thigh Cuffs on Dry Immersion-Induced Ophthalmological Changes Open
Neuro-ophthalmological changes named spaceflight associated neuro-ocular syndrome (SANS) reported after spaceflights are important medical issues. Dry immersion (DI), an analog to microgravity, rapidly induces a centralization of body flui…
View article: Reduced regional cerebral blood flow measured by 99mTc-HMPAO SPECT in microgravity simulated by 5-day dry immersion
Reduced regional cerebral blood flow measured by 99mTc-HMPAO SPECT in microgravity simulated by 5-day dry immersion Open
Purpose Neuro-ophthalmological changes defined as spaceflight-associated neuro-ocular syndrome have been reported after long duration space flights. The pathophysiology of this syndrome remains unclear, with the possible involvement of ele…
View article: Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation
Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation Open
It is well known that exposure to microgravity in astronauts leads to a plethora physiological responses such as headward fluid shift, body unloading, and cardiovascular deconditioning. When astronauts return to Earth, some encounter probl…
View article: Evaluation of upconverting nanoparticles towards heart theranostics
Evaluation of upconverting nanoparticles towards heart theranostics Open
Restricted and controlled drug delivery to the heart remains a challenge giving frequent off-target effects as well as limited retention of drugs in the heart. There is a need to develop and optimize tools to allow for improved design of d…
View article: Effects of Resistance Exercise and Nutritional Supplementation on Dynamic Cerebral Autoregulation in Head-Down Bed Rest
Effects of Resistance Exercise and Nutritional Supplementation on Dynamic Cerebral Autoregulation in Head-Down Bed Rest Open
Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR…
View article: Evaluation of Upconverting nanoparticles towards heart theranostics
Evaluation of Upconverting nanoparticles towards heart theranostics Open
Restricted and controlled drug delivery to the heart remains a challenge giving frequent off-target effects as well as limited retention of drugs in the heart. There is a need to develop and optimize tools to allow for improved design of d…
View article: Cerebral autoregulation in migraine with aura: A case control study
Cerebral autoregulation in migraine with aura: A case control study Open
Background Migraine with aura is independently associated with increased risk of ischemic stroke, especially in younger subjects. This association might be related to an impairment of cerebral autoregulation, which normally maintains cereb…
View article: Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation
Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation Open
Dry immersion (DI) is used to simulate weightlessness. We investigated in healthy volunteers if DI induces changes in ONSD, as a surrogate marker of intracranial pressure (ICP) and how these changes could affect cerebral autoregulation (CA…