Marc Lucas Appis
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View article: Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors
Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors Open
The immunosuppressive tumour microenvironment (TME) remains a central barrier to effective immunotherapy in solid tumours. We present a gene-therapeutic strategy that enables localized remodelling of the TME via tumour-intrinsic cytokine e…
View article: mtscMultiome ATAC + GEX v1
mtscMultiome ATAC + GEX v1 Open
mtscMultiome ATAC + GEX integrates the capture of mitochondrial DNA (mtDNA) for variant calling from the mitochondrial genome into the 10x Genomics Multiome ATAC + GEX workflow (now Epi Multiome ATAC + Gene Expression). The protocol was de…
View article: Personalized CRISPR Knock-In Cytokine Gene Therapy to Remodel the Tumor Microenvironment and Enhance CAR T Cell Therapy in Solid Tumors
Personalized CRISPR Knock-In Cytokine Gene Therapy to Remodel the Tumor Microenvironment and Enhance CAR T Cell Therapy in Solid Tumors Open
The immunosuppressive tumor microenvironment (TME) remains a central barrier to effective immunotherapy in solid tumors. To address this, we developed a novel gene therapeutic strategy that enables localized remodeling of the TME via tumor…
View article: Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells
Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells Open
A subset of T regulatory cells (Tregs), identified by TIRC7 (T cell immune response cDNA 7) expression is designated as Immune Regulatory 1 Cells (IR1 cells). TIRC7 is an immune checkpoint inhibitor, co-localized with the T- cell receptor,…