David Saadoun
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View article: Integrated transcriptomic and proteomic analysis reveals innate and adaptive immune dynamics in systemic autoinflammatory diseases
Integrated transcriptomic and proteomic analysis reveals innate and adaptive immune dynamics in systemic autoinflammatory diseases Open
Immune responses in systemic autoinflammatory disease (SAID) were investigated by multi-omics analysis, integrating RNA expression and proteomic data. By identifying the top 10 co-expressed transcripts of IL1B and BLNK, we demonstrated the…
View article: Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients Open
Objectives Giant cell arteritis (GCA) is a large‐vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation sign…
View article: Biological therapies in pediatric Behçet’s disease: results of an international collaborative study by the PRES Vasculitis Working Party
Biological therapies in pediatric Behçet’s disease: results of an international collaborative study by the PRES Vasculitis Working Party Open
Objective This study aims to examine the indications for pediatric rheumatologists to use biologic therapies in childhood Behçet’s disease (BD), as well as the efficacy, safety, and remission rates of such treatments. We also compare demog…
View article: Cardiac Manifestations in Behçet’s Syndrome
Cardiac Manifestations in Behçet’s Syndrome Open
Purpose of the Review Behçet’s Syndrome (BS) is a multisystemic vasculitis that can affect the heart, leading to pericarditis, myocarditis, intracardiac thrombosis, endomyocardial fibrosis, valvular dysfunction, and coronary artery disease…
View article: Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement
Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement Open
In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminu…
View article: POS0315 CORTICOSTEROIDS ALONE VERSUS CORTICOSTEROIDS PLUS DMARDS AS INDUCTION THERAPY IN NON-ANTERIOR SARCOIDOSIS UVEITIS
POS0315 CORTICOSTEROIDS ALONE VERSUS CORTICOSTEROIDS PLUS DMARDS AS INDUCTION THERAPY IN NON-ANTERIOR SARCOIDOSIS UVEITIS Open
View article: Characteristics of SARS-CoV-2-associated severe episodes of monoclonal gammopathy-associated capillary leak syndrome (Clarkson disease)
Characteristics of SARS-CoV-2-associated severe episodes of monoclonal gammopathy-associated capillary leak syndrome (Clarkson disease) Open
Background Monoclonal gammopathy-associated capillary leak syndrome (MG-CLS) is a rare condition characterized by recurrent episodes of hypovolemic shock caused by a sudden increase in capillary permeability. The COVID-19 pandemic has been…
View article: Deep Immunophenotyping and Clustering Identifies Biomarkers Predictive of Lymphoma in Primary Sjögren Disease
Deep Immunophenotyping and Clustering Identifies Biomarkers Predictive of Lymphoma in Primary Sjögren Disease Open
Objective Patients with primary Sjögren disease (pSD) are prone to develop non‐Hodgkin lymphoma (NHL), but relevant biomarkers are lacking. We aimed to determine new biomarkers predictive of NHL in patients with pSD. Methods Two hundred si…
View article: Genome-wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Genome-wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients Open
Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation sign…
View article: Histological pattern of non-infectious thoracic aortitis impacts mortality
Histological pattern of non-infectious thoracic aortitis impacts mortality Open
View article: Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease
Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease Open
View article: IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes
IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes Open
View article: French protocol for the diagnosis and management of giant cell arteritis
French protocol for the diagnosis and management of giant cell arteritis Open
Giant cell arteritis (GCA) is a large-vessel vasculitis that mainly affects women over fifty. GCA usually involves branches from the external carotid arteries, causing symptoms such as headaches, scalp tenderness, and jaw claudication. The…
View article: Clinical correlates of lifetime and current comorbidity patterns in autoimmune and inflammatory diseases
Clinical correlates of lifetime and current comorbidity patterns in autoimmune and inflammatory diseases Open
In this study, we have uncovered three distinct comorbidity profiles among AID patients. These profiles suggest the presence of distinct etiopathogenic mechanisms underlying these subgroups. Validation, longitudinal stability assessment, a…
View article: PUPAID: A R + ImageJ pipeline for thorough and semi-automated processing and analysis of multi-channel immunofluorescence data
PUPAID: A R + ImageJ pipeline for thorough and semi-automated processing and analysis of multi-channel immunofluorescence data Open
PUPAID is a workflow written in R + ImageJ languages which is dedicated to the semi-automated processing and analysis of multi-channel immunofluorescence data. The workflow is designed to extract fluorescence signals within automatically-s…
View article: Cellular pattern and orbital fat involvement are possible risk factors for the failure of corticosteroids in patients with pure idiopathic orbital inflammation syndrome: lessons from the French prospective <i>SIOI</i> cohort study (part II)
Cellular pattern and orbital fat involvement are possible risk factors for the failure of corticosteroids in patients with pure idiopathic orbital inflammation syndrome: lessons from the French prospective <i>SIOI</i> cohort study (part II) Open
Purpose To better characterise the effects of corticosteroids on the course of pure idiopathic orbital inflammation syndrome (pIOIS). Methods This was a national, multicentre, prospective, non-interventional cohort study ( SIOI ). Among th…
View article: Clinical spectrum and outcome of Takayasu's arteritis in children
Clinical spectrum and outcome of Takayasu's arteritis in children Open
View article: Polymyalgia rheumatica and giant cell arteritis following COVID-19 vaccination: Results from a nationwide survey
Polymyalgia rheumatica and giant cell arteritis following COVID-19 vaccination: Results from a nationwide survey Open
We conducted a national in-depth analysis including pharmacovigilance reports and clinical study to assess the reporting rate (RR) and to determine the clinical profile of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) in COVI…
View article: Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types Open
View article: Deep Immunophenotyping and Clustering Identifies Biomarkers Predictive of Lymphoma in Primary Sjögren's Syndrome
Deep Immunophenotyping and Clustering Identifies Biomarkers Predictive of Lymphoma in Primary Sjögren's Syndrome Open
View article: Validation of the PEDiatric Behçet’s Disease classification criteria: an evidence-based approach
Validation of the PEDiatric Behçet’s Disease classification criteria: an evidence-based approach Open
Objectives To validate the PEDiatric Behçet’s Disease classification criteria (PEDBD) with an evidence-based approach. Methods A total of 210 pediatric patients [70 Behçet’s disease (BD), 40 periodic fever, aphthous stomatitis, pharyngitis…
View article: Cluster Analysis to Explore Clinical Subphenotypes of Eosinophilic Granulomatosis With Polyangiitis
Cluster Analysis to Explore Clinical Subphenotypes of Eosinophilic Granulomatosis With Polyangiitis Open
Objective Previous studies suggested that distinct phenotypes of eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome) could be determined by the presence or absence of antineutrophil cytoplasmic an…
View article: Eosinophilic granulomatosis polyangiitis (EGPA) complicated with periaortitis, precipitating role of dupilumab? A case report a review of the literature
Eosinophilic granulomatosis polyangiitis (EGPA) complicated with periaortitis, precipitating role of dupilumab? A case report a review of the literature Open
Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis that affects small size vessels. Only four cases of periaortitis associated with EGPA have been reported in the literature. We report the case of a 67-ye…
View article: The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial Open
View article: CTLA-4 Pathway Is Instrumental in Giant Cell Arteritis
CTLA-4 Pathway Is Instrumental in Giant Cell Arteritis Open
BACKGROUND: Giant cell arteritis (GCA) causes severe inflammation of the aorta and its branches and is characterized by intense effector T-cell infiltration. The roles that immune checkpoints play in the pathogenesis of GCA are still uncle…
View article: POS0740 VALIDATION OF THE PEDIATRIC BEHÇET DISEASE CRITERIA (PEDBD): A REAL LIFE CONSENSUS-BASED APPROACH
POS0740 VALIDATION OF THE PEDIATRIC BEHÇET DISEASE CRITERIA (PEDBD): A REAL LIFE CONSENSUS-BASED APPROACH Open
View article: Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study
Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study Open
Objectives In this large multicentre study, we compared the effectiveness and safety of tocilizumab intravenous versus subcutaneous (SC) in 109 Takayasu arteritis (TAK) patients. Methods We conducted a retrospective multicentre study in re…
View article: Behçet’s Disease Uveitis
Behçet’s Disease Uveitis Open
Uveitis in Behçet’s disease (BD) is frequent (40% of cases) and is a major cause of morbidity. The age of onset of uveitis is between 20 and 30 years. Ocular involvement includes anterior, posterior, or panuveitis. Uveitis may be the first…
View article: Occurrence of focal myositis during Behçet's disease: The identification of a specific vasculitis‐associated focal myopathy
Occurrence of focal myositis during Behçet's disease: The identification of a specific vasculitis‐associated focal myopathy Open
Aims This study aimed to report the association of focal myositis (FM) and Behçet's disease (BD) and to analyse the main characteristics of such an association. Methods This is a retrospective multicentre study of patients with BD and FM (…
View article: Severe SARS-Cov2 pneumonia in vaccinated patients: a multicenter cohort study
Severe SARS-Cov2 pneumonia in vaccinated patients: a multicenter cohort study Open