Marc P. Hübner
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View article: The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity
The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity Open
View article: Mansonella perstans – the forgotten filaria
Mansonella perstans – the forgotten filaria Open
Mansonella perstans is the most prevalent human filarial parasite, infecting over 100 million people worldwide. Despite its wide distribution, it remains one of the most neglected parasitic infections, largely due to its asymptomatic clini…
View article: Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics
Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics Open
Filarial nematodes, responsible for diseases like lymphatic filariasis and onchocerciasis, depend on symbiotic Wolbachia bacteria for reproduction and development. Using the Litomosoides sigmodontis rodent model, we investigated how host t…
View article: Diagnosis, management and prevention of loiasis: guideline of the German Society for Tropical Medicine, Travel Medicine, and Global Health (DTG)
Diagnosis, management and prevention of loiasis: guideline of the German Society for Tropical Medicine, Travel Medicine, and Global Health (DTG) Open
Loiasis is a complex filarial infection endemic in Central Africa and parts of West Africa. Loa loa is transmitted by the deer fly Chrysops dimidiata and C. silacea . The clinical manifestation of the disease is highly variable ranging fro…
View article: Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis</i> Filarial Infection
Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis</i> Filarial Infection Open
T follicular helper (T FH ) cells are the primary CD4 + T helper cell subset providing help to B cells for efficient antibody responses in vaccination, allergy, autoimmunity, and infectious diseases. Despite their critical involvement in i…
View article: Novel treatments offer hope for neglected tropical diseases
Novel treatments offer hope for neglected tropical diseases Open
Novel treatments offer hope for neglected tropical diseases Researchers at the Institute of Medical Microbiology, Immunology and Parasitology (IMMIP) at the University of Bonn are pioneering innovative treatment strategies for neglected tr…
View article: Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis
Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis Open
Eosinophils are a hallmark of filarial infections. They are primary effector cells and can attack filariae by releasing extracellular traps that contain toxic cationic proteins, such as eosinophil peroxidase and major basic protein. Previo…
View article: Host environment shapes filarial parasite fitness and <i>Wolbachia</i> endosymbionts dynamics
Host environment shapes filarial parasite fitness and <i>Wolbachia</i> endosymbionts dynamics Open
Summary Filarial nematodes, responsible for diseases like lymphatic filariasis and onchocerciasis, depend on symbiotic Wolbachia bacteria for reproduction and development. Using the Litomosoides sigmodontis rodent model, we investigated ho…
View article: Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway
Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway Open
Granulocytes exert several effector mechanisms, including the release of DNA traps during ETosis. While bacteria-induced ETosis has been linked to the non-canonical inflammasome pathway, the role of the inflammasome activation during ETosi…
View article: Exploring the Bi-Directional Relationship between Protozoan Blastocystis Hominis, Giardia Lamblia and Dientamoeba Fragilis and Nutrition in Children from Pasto, Colombia: Influence of Socioeconomic, Sanitary and Spatial Drivers
Exploring the Bi-Directional Relationship between Protozoan Blastocystis Hominis, Giardia Lamblia and Dientamoeba Fragilis and Nutrition in Children from Pasto, Colombia: Influence of Socioeconomic, Sanitary and Spatial Drivers Open
View article: Revision of the “Guideline of the German Medical Association on Quality Assurance in Medical Laboratory Examinations – Rili-BAEK”
Revision of the “Guideline of the German Medical Association on Quality Assurance in Medical Laboratory Examinations – Rili-BAEK” Open
View article: Differences of in vitro immune responses between patent and pre-patent Litomosoides sigmodontis–infected mice are independent of the filarial antigenic stimulus used
Differences of in vitro immune responses between patent and pre-patent Litomosoides sigmodontis–infected mice are independent of the filarial antigenic stimulus used Open
View article: Seroprevalence and Association of Toxoplasma gondii with Bone Health in a Cohort of Osteopenia and Osteoporosis Patients
Seroprevalence and Association of Toxoplasma gondii with Bone Health in a Cohort of Osteopenia and Osteoporosis Patients Open
Considering the fact that Toxoplasma is a common parasite of humans and Toxoplasma bradyzoites can reside in skeletal muscle, T. gondii-mediated immune responses may modulate the progression and pathophysiology of another musculoskeletal d…
View article: Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations
Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations Open
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle scree…
View article: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner
Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner Open
Background Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy an…
View article: Intramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome
Intramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome Open
View article: Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response
Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response Open
Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model…
View article: Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis Open
Lymphatic filariasis and onchocerciasis are two major neglected tropical diseases that are responsible for causing severe disability in 50 million people worldwide, whilst veterinary filariasis (heartworm) is a potentially lethal parasitic…
View article: Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia
Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia Open
Onchocerciasis treatment and control relies mainly on the use of ivermectin which has high activity against the microfilarial stage of Onchocerca volvulus but limited activity against the long-lived, tissue dwelling adult nematodes. As thi…
View article: Development of adult Dirofilaria immitis worms in the Rag2/Il-2rγ mouse model
Development of adult Dirofilaria immitis worms in the Rag2/Il-2rγ mouse model Open
Dirofilaria immitis is the causative agent for one of the major parasitic infections in dogs. It is currently not possible to reliably diagnose the infection before the development of fertile adult female worms and the presence of microfil…
View article: Onchocerciasis Drug Discovery: In vitro Evaluation of FDA- Approved Drugs against Onchocerca gutturosa in Gambia
Onchocerciasis Drug Discovery: In vitro Evaluation of FDA- Approved Drugs against Onchocerca gutturosa in Gambia Open
Onchocerciasis treatment and control relies mainly on the use of ivermectin which has high activity against the microfilarial stage of Onchocerca volvulus but limited activity against the long lived, tissue dwelling adult nematodes. As thi…
View article: Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response
Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response Open
Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model…
View article: Hemophagocytic lymphohistiocytosis—how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature
Hemophagocytic lymphohistiocytosis—how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature Open
Background Infection-associated secondary hemophagocytic lymphohistiocytosis (sHLH) is a potentially life-threatening hyperinflammatory condition caused by various infectious diseases. Malaria has rarely been described as trigger. The aim …
View article: First case of <i>Dirofilaria hongkongensis</i> infection in Germany presenting as a breast tumour
First case of <i>Dirofilaria hongkongensis</i> infection in Germany presenting as a breast tumour Open
A breast tumour in an Indian born German Traveller surprisingly turned out to be an infection with Dirofilaria hongkongensis - a zoonosis on the rise in endemic areas and the first reported case in Germany.
View article: The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system Open
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is cu…
View article: The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in Cameroon
The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in Cameroon Open
Background Life-style metabolic diseases are steadily rising, not only in developed countries, but also in low- and middle-income countries, presenting a global health problem. Metabolic disorders like type 2 diabetes and cardiovascular di…
View article: Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis
Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis Open
More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated…
View article: Development of a Novel Enzyme-Linked Immunosorbent Assay and Lateral Flow Test System for Improved Serodiagnosis of Visceral Leishmaniasis in Different Areas of Endemicity
Development of a Novel Enzyme-Linked Immunosorbent Assay and Lateral Flow Test System for Improved Serodiagnosis of Visceral Leishmaniasis in Different Areas of Endemicity Open
Reliable and field suitable serodiagnosis of visceral leishmaniasis (VL) in East Africa has until now been a big challenge due to low sensitivity and cross-reactivity with other pathogens. To improve VL serodiagnosis, a new recombinant kin…
View article: Filariasis research – from basic research to drug development and novel diagnostics, over a decade of research at the Institute for Medical Microbiology, Immunology and Parasitology, Bonn, Germany
Filariasis research – from basic research to drug development and novel diagnostics, over a decade of research at the Institute for Medical Microbiology, Immunology and Parasitology, Bonn, Germany Open
Filariae are vector borne parasitic nematodes, endemic in tropical and subtropical regions causing avoidable infections ranging from asymptomatic to stigmatizing and disfiguring disease. The filarial species that are the major focus of our…
View article: Application of loop mediated isothermal amplification (LAMP) assays for the detection of Onchocerca volvulus, Loa loa and Mansonella perstans in humans and vectors
Application of loop mediated isothermal amplification (LAMP) assays for the detection of Onchocerca volvulus, Loa loa and Mansonella perstans in humans and vectors Open
Conventional diagnosis of filarial infections is based on morphological identification of microfilariae using light microscopy and requires considerable expertise, is time-consuming, and can be subjective. Loop-mediated isothermal amplific…