Marc Pawlitzki
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View article: Early Versus Delayed Add-on Therapy in Generalized Myasthenia Gravis: A Multicenter Real-World Cohort Study
Early Versus Delayed Add-on Therapy in Generalized Myasthenia Gravis: A Multicenter Real-World Cohort Study Open
Objective This study examined whether the timing of targeted add-on therapy initiation influences clinical outcomes in acetylcholine receptor (AChR) antibody-positive generalized myasthenia gravis (gMG), based on the hypothesis that earlie…
View article: Wearable Monitoring Captures Sleep Disturbances in Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Wearable Monitoring Captures Sleep Disturbances in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Open
Background and Aims Previous studies suggest that patients with chronic inflammatory demyelinating polyneuropathy (CIDP) experience impaired sleep, contributing to fatigue. Traditional methods like polysomnography or questionnaires are res…
View article: Structural connectomic signatures of childhood maltreatment across affective and psychotic disorders
Structural connectomic signatures of childhood maltreatment across affective and psychotic disorders Open
Exposure to childhood maltreatment (CM) is a crucial risk factor for affective disorders and schizophrenia, which are linked to structural brain network alterations. We hypothesized a significant association between CM and brain structural…
View article: Evaluating Web Retrieval–Assisted Large Language Models With and Without Whitelisting for Evidence-Based Neurology: Comparative Study
Evaluating Web Retrieval–Assisted Large Language Models With and Without Whitelisting for Evidence-Based Neurology: Comparative Study Open
Background Large language models (LLMs) coupled with real-time web retrieval are reshaping how clinicians and patients locate medical evidence, and as major search providers fuse LLMs into their interfaces, this hybrid approach might becom…
View article: Analyzing Access to Child and Adolescent Psychiatric Care Institutes in Germany Based on Driving Time
Analyzing Access to Child and Adolescent Psychiatric Care Institutes in Germany Based on Driving Time Open
Objective: While structured treatment programs for children and adolescents with psychiatric disorders exist, their geographic distribution remains unclear. Specialized addiction treatment facilities for young patients are particularly sca…
View article: Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy
Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy Open
Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic m…
View article: Isochrone-based Identification of Gaps in Neurovascular Care in Germany
Isochrone-based Identification of Gaps in Neurovascular Care in Germany Open
Purpose Modern endovascular techniques enable the treatment of various neurovascular diseases. Given the complexity of these interventions, a certification system was introduced to ensure standardized care at specialized treatment centers.…
View article: Caregiving burden among caregivers of people with myasthenia gravis
Caregiving burden among caregivers of people with myasthenia gravis Open
Introduction/aims Informal caregivers play an important role in the lives of people with Myasthenia gravis (MG). This study aims to assess the caregiver burden (CB) experienced by caregivers of MG patients. Methods A cross-sectional study …
View article: Natural killer cells are a potential source of oxidative stress in inclusion body myositis
Natural killer cells are a potential source of oxidative stress in inclusion body myositis Open
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy in individuals over 50 years of age. IBM is considered a T cell-mediated disease. In contrast, the role of natural killer (NK) cells remains understudied. He…
View article: Effects of Anti-CD20 Antibody Therapy on Immune Cell Dynamics in Relapsing-Remitting Multiple Sclerosis
Effects of Anti-CD20 Antibody Therapy on Immune Cell Dynamics in Relapsing-Remitting Multiple Sclerosis Open
Introduction: The efficacy of anti-CD20 antibodies has significantly contributed to advancing our understanding of disease pathogenesis and improved treatment outcomes in relapsing-remitting multiple sclerosis (RRMS). A comprehensive analy…
View article: Evaluating base and retrieval augmented LLMs with document or online support for evidence based neurology
Evaluating base and retrieval augmented LLMs with document or online support for evidence based neurology Open
View article: Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms Open
View article: Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders
Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders Open
A wide variety of immunomodulatory therapies are already available for the treatment of multiple sclerosis (MS). Through fundamental insights from basic research with a gain of knowledge in the pathological processes underlying MS, the exp…
View article: C5 complement inhibition versus FcRn modulation in generalised myasthenia gravis
C5 complement inhibition versus FcRn modulation in generalised myasthenia gravis Open
Background Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions, leading to fluctuating muscle weakness. While many patients respond well to standard immunosuppression, a substantial subgroup faces ongoing dis…
View article: LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro
LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro Open
For the last 38 years, all neuroprotective agents for patients with ischemic stroke have failed in clinical trials. The innate immune system, particularly microglia, is a much-discussed target for neuroprotective agents. Promising results …
View article: Abatacept Induces Long-Term Reconstitution of the B-Cell Niche in a Patient With CTLA-4 Haploinsufficiency
Abatacept Induces Long-Term Reconstitution of the B-Cell Niche in a Patient With CTLA-4 Haploinsufficiency Open
As a single report without controls, this report provides class IV evidence that abatacept might revert lymphopenia in patients with CTLA-4 haploinsufficiency.
View article: Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies Open
View article: Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy – a cross-sectional study
Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy – a cross-sectional study Open
Background While several studies in cerebral amyloid angiopathy (CAA) focus on cognitive function, data on neuropsychiatric symptoms (NPS) and lifelong mental activities in these patients are scarce. Since NPS are associated with functiona…
View article: Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)
Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS) Open
Post-acute COVID-19 vaccination syndrome (PACVS) is a chronic disease triggered by SARS-CoV-2 vaccination (estimated prevalence 0.02%). PACVS is discriminated from the normal post-vaccination state by altered receptor antibodies, most nota…
View article: Preventing long-term disability in CIDP: the role of timely diagnosis and treatment monitoring in a multicenter CIDP cohort
Preventing long-term disability in CIDP: the role of timely diagnosis and treatment monitoring in a multicenter CIDP cohort Open
Background Chronic inflammatory demyelinating polyneuropathy (CIDP) is an inflammatory disease affecting the peripheral nerves and the most frequent autoimmune polyneuropathy. Given the lack of established biomarkers or risk factors for th…
View article: Triage Performance Across Large Language Models, ChatGPT, and Untrained Doctors in Emergency Medicine: Comparative Study
Triage Performance Across Large Language Models, ChatGPT, and Untrained Doctors in Emergency Medicine: Comparative Study Open
Background Large language models (LLMs) have demonstrated impressive performances in various medical domains, prompting an exploration of their potential utility within the high-demand setting of emergency department (ED) triage. This stud…
View article: Association of Clinical Relapses With Disease Outcomes in Multiple Sclerosis Patients Older Than 50 Years
Association of Clinical Relapses With Disease Outcomes in Multiple Sclerosis Patients Older Than 50 Years Open
A relapse-suggesting underlying active disease-in PwMS older than 50 years was associated with continued disease activity and increased risk of PIRA. Presence of CVRF and absence of DMT at baseline appeared as risk factors of disadvantageo…
View article: Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)
Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS) Open
Post-acute COVID-19 vaccination syndrome (PACVS) is distinguished from the normal post-vaccination state by altered receptor antibodies (Semmler et al. Vaccines 2023, 11, 1642). Here, we explore the symptoms registry and standard serum mar…
View article: Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis Open
Myasthenia gravis is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Informative biomarkers remain an unmet need to stratify patients with active disease requiring intensified monitoring and t…
View article: The three-year evolution of Germany’s Digital Therapeutics reimbursement program and its path forward
The three-year evolution of Germany’s Digital Therapeutics reimbursement program and its path forward Open
The 2019 German Digital Healthcare Act introduced the Digital Health Application program, known in German as ‘Digitale Gesundheitsanwendungen’ (DiGA). The program has established a pioneering model for integrating Digital Therapeutics (DTx…
View article: The PNS Nurse Program
The PNS Nurse Program Open
Ultimately, the PNS Nurse Education Program aims to bridge the gap between complex treatments and limited specialized care, improving patient outcomes and relieving burdens on patients, caregivers, and healthcare systems.
View article: Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management
Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management Open
View article: Risk factors for intracerebral hemorrhage in small-vessel disease and non-small-vessel disease etiologies—an observational proof-of-concept study
Risk factors for intracerebral hemorrhage in small-vessel disease and non-small-vessel disease etiologies—an observational proof-of-concept study Open
Background Sporadic cerebral small-vessel disease (CSVD), i.e., hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA), is the main cause of spontaneous intracerebral hemorrhage (ICH). Nevertheless, a substantial portion of I…
View article: Ravulizumab in myasthenic crisis: the first case report
Ravulizumab in myasthenic crisis: the first case report Open
View article: The Use of Nitrosative Stress Molecules as Potential Diagnostic Biomarkers in Multiple Sclerosis
The Use of Nitrosative Stress Molecules as Potential Diagnostic Biomarkers in Multiple Sclerosis Open
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) of still unclear etiology. In recent years, the search for biomarkers facilitating its diagnosis, prognosis, therapy response, and other parameters has ga…