Explanipedia

Unique brain injury patterns after proton vs photon radiotherapy for WHO grade 2-3 gliomas Open

Sebastian Winter, Melissa M Gardner, Philipp Karschnia, Eugene Vaios, Clemens Grassberger , et al. · 2024

Background Central nervous system (CNS) injury following brain-directed radiotherapy remains a major challenge. Proton radiotherapy (PRT) minimizes radiation to healthy brain, potentially limiting sequelae. We characterized CNS radiotoxici…

Dosimetric Comparison of Proton Versus Photon Stereotactic Radiosurgery for Treatment of Vestibular Schwannom Open

Shivani Sud, Marc R. Bussière, Thomas Botticello, Andrzej Niemierko, Adam Schwartz , et al. · 2023

RADT-23. MODALITY-SPECIFIC CNS INJURY FOLLOWING PROTON VS PHOTON BEAM RADIOTHERAPY IN GLIOMA Open

Sebastian Winter, Melissa M Gardner, Michael Parsons, Clemens Grassberger, Marc R. Bussière , et al. · 2022

BACKGROUND CNS injury following brain-directed radiotherapy (RT) is common and may mimic disease progression. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiation to healthy brain, potentially limiting radiotoxic se…

Effect of proton radiation therapy on cardiovascular implantable electronic devices [CIED] Open

Esra D. Gumuser, Zain Sharif, Rady Ho, John D. Allison, Audrey Aitelli , et al. · 2022

Background The number of cancer patients with CIED receiving radiotherapy has increased dramatically with improving life expectancy in both patients with cardiovascular disease and cancer. The advent of proton therapy adds new concern for …

Proton Stereotactic Radiotherapy for Treatment of Nelson's Syndrome Open

D W Kim, GUAT-SIEW LEE, Emma Cai, Brooke Swearingen, Paul H. Chapman , et al. · 2021

Dosimetric Comparison of Proton Versus Photon Radiosurgery for Treatment of Pituitary Adenoma Open

Shivani Sud, Thomas Botticello, Andrzej Niemierko, J. Daly, Marc R. Bussière , et al. · 2021

We demonstrate that neither modality has empirically superior dosimetry and identify potential clinical advantages as well as limitations of each technique. PSRS, 5XSRS and 2.5XSRS demonstrate comparable target volume dosimetry for pituita…

Defining Treatment-Related Adverse Effects in Patients with Glioma: Distinctive Features of Pseudoprogression and Treatment-Induced Necrosis Open

Sebastian Winter, Eugene Vaios, Alona Muzikansky, Maria Martinez‐Lage, Marc R. Bussière , et al. · 2020

Background Pseudoprogression (PP) and treatment-induced brain tissue necrosis (TN) are challenging cancer treatment–related effects. Both phenomena remain insufficiently defined; differentiation from recurrent disease frequently necessitat…

NCMP-22. TREATMENT-RELATED ADVERSE EFFECTS IN PATIENTS WITH MALIGNANT GLIOMA: ESTABLISHMENT OF KEY FEATURES FOR PSEUDOPROGRESSION AND TREATMENT-INDUCED NECROSIS. Open

Sebastian Winter, Eugene Vaios, Alona Muzikansky, Marc R. Bussière, Helen A. Shih , et al. · 2018

OBJECTIVE: Pseudoprogression (PP) and treatment-induced necrosis (TN) are insufficiently characterized, clinically challenging conditions. Since both entities radiographically mimic recurrent disease, patients frequently require surgical i…

NCMP-17. EVOLUTION OF CEREBRAL MICROBLEEDS AFTER PROTON IRRADIATION IN LOW-GRADE GLIOMA PATIENTS Open

Thanakit Pongpitakmetha, Michael Parsons, Marc R. Bussière, Anand Viswanathan, Helen A. Shih , et al. · 2018

BACKGROUND: Cranial irradiation is associated with neurovascular injury, such as cerebral microbleeds (CMBs). We have previously shown that CMBs progressively increase in number with each year after completion of photon-based radiation the…

P01.105 Clinical and imaging features of pseudoprogression in malignant glioma. Open

Sebastian Winter, Eugene Vaios, Alona Muzikansky, Marc R. Bussière, Helen A. Shih , et al. · 2018

Pseudoprogression (PP) likely represents a unique phenomenon encountered in high-grade glioma patients within the first six months of combined chemoradiation. As PP mimics recurrent disease, patients may need a tissue biopsy to guide manag…

The role of radiotherapy in the management of high-grade meningiomas Open

Katie L. Hwang, William L. Hwang, Marc R. Bussière, Helen A. Shih · 2017

Meningiomas account for approximately one-third of primary central nervous system tumors with a subset that are aggressive and carry significant morbidity and mortality. Treatment of these high-grade meningiomas, classified by the World He…

Spatiotemporal Fractionation Schemes for Irradiating Large Cerebral Arteriovenous Malformations Open

Jan Unkelbach, Marc R. Bussière, Paul H. Chapman, Jay S. Loeffler, Helen A. Shih · 2016

Cost effectiveness of proton versus photon radiation therapy with respect to the risk of growth hormone deficiency in children Open

Raymond B. Mailhot Vega, Jane Kim, Abby Hollander, Jona A. Hattangadi‐Gluth, Jeff M. Michalski , et al. · 2015

BACKGROUND Proton therapy in pediatrics may improve the risk/benefit profile of radiotherapy at a greater upfront financial cost, but it may prove to be cost effective if chronic medical complications can be avoided. Tools to assist with d…

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