Jean‐Marc Schwarz
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View article: Effect of weight gain on blood pressure in Ugandan persons with HIV on dolutegravir/lamivudine/ tenofovir disoproxil fumarate over 48 weeks
Effect of weight gain on blood pressure in Ugandan persons with HIV on dolutegravir/lamivudine/ tenofovir disoproxil fumarate over 48 weeks Open
Background Most people living with HIV in low and middle-income countries are taking fixed dose combination tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD). Dolutegravir use has been associated with weight gain, a known risk fa…
View article: Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults
Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults Open
(1) Background: Clinical results on the effects of excess sugar consumption on insulin sensitivity are conflicting, possibly due to differences in sugar type and the insulin sensitivity index (ISI) assessed. Therefore, we compared the effe…
View article: Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults Open
Background The Uganda Ministry of Health issued restrictive guidelines on the use of dolutegravir (DTG) in persons stratified to have a heightened risk of diabetes mellitus. This followed multiple reports of persons with HIV (PWH) presenti…
View article: PREVALENCE OF CARDIOMETABOLIC DISEASE RISK FACTORS IN PEOPLE LIVING WITH HIV INITIATING ANTI-RETROVIRAL THERAPY AT A HIGH-VOLUME HIV CLINIC IN KAMPALA, UGANDA
PREVALENCE OF CARDIOMETABOLIC DISEASE RISK FACTORS IN PEOPLE LIVING WITH HIV INITIATING ANTI-RETROVIRAL THERAPY AT A HIGH-VOLUME HIV CLINIC IN KAMPALA, UGANDA Open
Therapeutic Area: Cardiovascular diseases among Persons Living With HIV Background: Cardiometabolic diseases are a leading cause of HIV-related morbidity and mortality, yet HIV treatment programs in high burden countries have been slow to …
View article: Should dolutegravir always be withheld in people with HIV on dolutegravir with incident diabetes mellitus? A case report
Should dolutegravir always be withheld in people with HIV on dolutegravir with incident diabetes mellitus? A case report Open
Dolutegravir (DTG), an integrase strand transfer inhibitor is currently the recommended first and second line anti-retroviral therapy (ART) anchor agent by the World Health Organization. This followed widespread reports of primary resistan…
View article: Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults Open
Background The Uganda Ministry of Health issued restrictive guidelines on the use of dolutegravir (DTG) in persons stratified to have a heightened risk of diabetes mellitus. This followed multiple reports of persons with HIV (PWH) presenti…
View article: Prevalence of Cardiometabolic Disease Risk Factors in People with HIV Initiating Anti-retroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda
Prevalence of Cardiometabolic Disease Risk Factors in People with HIV Initiating Anti-retroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda Open
Background Cardiometabolic diseases are a leading cause of HIV-related morbidity and mortality, yet routine screening is not undertaken in high burden countries. We aimed to assess the prevalence and risk factors of the metabolic syndrome …
View article: Prevalence of Cardiometabolic Disease Risk Factors in People living with HIV Initiating Anti-retroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda
Prevalence of Cardiometabolic Disease Risk Factors in People living with HIV Initiating Anti-retroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda Open
Background Cardiometabolic diseases are a leading cause of HIV-related morbidity and mortality, yet routine screening is not undertaken in high burden countries. We aimed to assess the prevalence and risk factors of the metabolic syndrome …
View article: Association between integrase strand transfer inhibitor use with insulin resistance and incident diabetes mellitus in persons living with HIV: a systematic review and meta-analysis
Association between integrase strand transfer inhibitor use with insulin resistance and incident diabetes mellitus in persons living with HIV: a systematic review and meta-analysis Open
Whether integrase strand transfer inhibitors (INSTIs) are associated with a higher risk of incident type 2 diabetes mellitus (DM) than other antiretroviral therapies (ART) needs to be established. MEDLINE, Embase, Web of Science, and Clini…
View article: 2022 AOA Research Abstracts and Poster Competition
2022 AOA Research Abstracts and Poster Competition Open
Science, Clinical, Health Services, and Public Health categories, indicated within each abstract immediately under the identification number.
View article: Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity
Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity Open
Sugar intake, particularly fructose, is implicated as a factor contributing to insulin resistance via hepatic de novo lipogenesis (DNL). A nine-day fructose reduction trial, controlling for other dietary factors and weight, in children wit…
View article: Association between integrase strand transfer inhibitor (INSTIs) use with insulin resistance and incident diabetes mellitus in persons living with HIV: A systematic review and meta-analysis protocol
Association between integrase strand transfer inhibitor (INSTIs) use with insulin resistance and incident diabetes mellitus in persons living with HIV: A systematic review and meta-analysis protocol Open
Introduction Poeple living with HIV have higher prevalence of diabetes mellitus and metabolic perturbations compared to non-HIV populations. Diabetes and metabolic syndrome co-morbidities add significant burden to HIV care. Currently, WHO …
View article: Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories
Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories Open
Summary Calories from any food have the potential to increase risk for obesity and cardiometabolic disease because all calories can directly contribute to positive energy balance and fat gain. However, various dietary components or pattern…
View article: Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases?
Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases? Open
Epidemiologic studies suggest a link between excess sugar consumption and obesity, fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus. One important pathway that may link these metabolic diseases to sugar consumption is …
View article: Proceedings of the 2nd International Conference on Obesity and Chronic Diseases (ICOCD-2017)
Proceedings of the 2nd International Conference on Obesity and Chronic Diseases (ICOCD-2017) Open
Obesity has been an epidemic in the US and world for more than two decades.Obesity is associated with serious health conditions, including type 2 diabetes, cardiovascular disease, certain types of cancers, hyperlipidemia, and liver steatos…
View article: Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome
Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome Open
Objective Dietary fructose is implicated in metabolic syndrome, but intervention studies are confounded by positive caloric balance, changes in adiposity, or artifactually high amounts. This study determined whether isocaloric substitution…
View article: Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat Open
Short-term high-fructose intake was associated with increased DNL and liver fat in healthy men fed weight-maintaining diets.
View article: Subchronic Sleep Restriction Causes Tissue-Specific Insulin Resistance
Subchronic Sleep Restriction Causes Tissue-Specific Insulin Resistance Open
Subchronic SR causes unique metabolic disturbances characterized by peripheral, but not hepatic, insulin resistance; this was associated with a robust increase in fasting NEFA levels (indicative of increased lipolysis), decreased RQ, and i…