Marc Sütterlin
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View article: Clinical benefit of additional whole-exome sequencing over panel sequencing in an all-comer real-world molecular tumor board
Clinical benefit of additional whole-exome sequencing over panel sequencing in an all-comer real-world molecular tumor board Open
In our MTB, WES enabled some additional clinically highly actionable recommendations for selected patients, suggesting that some patients do benefit from additional WES. These recommendations were often related to complex biomarkers, which…
View article: Evaluation of Sexual Function and Vaginal Prolapse Relapse in Patients Undergoing Laparoscopic Sacropexy <i>Versus</i> Pectopexy
Evaluation of Sexual Function and Vaginal Prolapse Relapse in Patients Undergoing Laparoscopic Sacropexy <i>Versus</i> Pectopexy Open
A comparable efficacy of apical fixation was found for LSP and LPP, complications were low in both groups, and the FSFI-results were comparable with slightly better results in the LPP group. Therefore, LPP seems to be a viable and safe alt…
View article: Invasive disease‐free and overall survival after (neo)adjuvant chemotherapy in postmenopausal patients with hormone receptor‐positive, <scp>HER2</scp>‐negative early breast cancer treated with upfront letrozole: Experiences from the phase <scp>IV PreFace</scp> trial
Invasive disease‐free and overall survival after (neo)adjuvant chemotherapy in postmenopausal patients with hormone receptor‐positive, <span>HER2</span>‐negative early breast cancer treated with upfront letrozole: Experiences from the phase <span>IV PreFace</span> trial Open
Patients with hormone receptor‐positive (HRpos), HER2‐negative (HER2neg) breast cancer (BC) benefit less from neoadjuvant chemotherapy (NACT) than patients with triple‐negative and HER2‐positive BC. In this retrospective analysis of the ph…
View article: Correction: ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Controlled Trial
Correction: ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Controlled Trial Open
[This corrects the article DOI: 10.2196/69855.].
View article: Oncological outcomes of breast cancer patients after planned IORT boost with low-kV x-rays—results of the TARGIT BQR prospective phase IV trial
Oncological outcomes of breast cancer patients after planned IORT boost with low-kV x-rays—results of the TARGIT BQR prospective phase IV trial Open
Purpose The TARGIT BQR (boost quality registry) phase IV trial investigates clinical outcomes of breast cancer patients with standard external-beam radiotherapy (EBRT) of the whole breast and intraoperative radiotherapy (IORT) with low-kV …
View article: Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer
Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer Open
Replication stress is a critical event in cancer development and understanding the underlying molecular mechanisms can help to identify new treatment strategies. Here, we investigate the molecular interplay between the pre-replication comp…
View article: Intermediate outcomes of children (4–10 years) with postnatally preserved renal function after vesico-amniotic shunt insertion for lower urinary tract obstruction (LUTO)
Intermediate outcomes of children (4–10 years) with postnatally preserved renal function after vesico-amniotic shunt insertion for lower urinary tract obstruction (LUTO) Open
The findings of our retrospective study suggest that when normal laboratory values for creatine, urea, and/or GFR are observed in the neonatal period following prenatal VAS for LUTO, these parameters will likely remain normal in most patie…
View article: Correlation of HLA-A and HLA-B/C Expression With PD-1 and PD-L1 Expression in Patients With Metastatic Breast Cancer as a Potential Prognosticator of Favorable Survival
Correlation of HLA-A and HLA-B/C Expression With PD-1 and PD-L1 Expression in Patients With Metastatic Breast Cancer as a Potential Prognosticator of Favorable Survival Open
This pilot study found no significant association between HLA-A, HLA-B/C, PD-1, or PD-L1 expression and OS in MBC, indicating limited prognostic value for these biomarkers in this cohort.
View article: Correlation of HLA-A and HLA-B/C Expression With ESR1 Expression in Patients With Metastatic Breast Cancer as a Potential Prognosticator of Favorable Distant Disease-free Survival
Correlation of HLA-A and HLA-B/C Expression With ESR1 Expression in Patients With Metastatic Breast Cancer as a Potential Prognosticator of Favorable Distant Disease-free Survival Open
A potential positive association between reduced expression of HLA-A and HLA-B/C and DDFS is observed. This contrasts with the generally observed association between HLA expression loss and poor prognosis, as reported in previous protein-b…
View article: Prognostic impact of selection criteria of current adjuvant endocrine therapy trials NATALEE and monarchE in postmenopausal HRpos/HER2neg breast cancer patients treated with upfront letrozole
Prognostic impact of selection criteria of current adjuvant endocrine therapy trials NATALEE and monarchE in postmenopausal HRpos/HER2neg breast cancer patients treated with upfront letrozole Open
Patient populations eligible for monarchE and NATALEE trials differed. Nearly a third of the postmenopausal HRpos population, previously under upfront letrozole treatment, met the NATALEE prognostic eligibility criteria. As certain eligibl…
View article: Tailored Dose-Dense Versus Standard Adjuvant Chemotherapy for High-Risk Early Breast Cancer: End-of-Study Results of the Randomized PANTHER Trial
Tailored Dose-Dense Versus Standard Adjuvant Chemotherapy for High-Risk Early Breast Cancer: End-of-Study Results of the Randomized PANTHER Trial Open
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …
View article: Acute and Long-Term Toxicity after Planned Intraoperative Boost and Whole Breast Irradiation in High-Risk Patients with Breast Cancer—Results from the Targeted Intraoperative Radiotherapy Boost Quality Registry (TARGIT BQR)
Acute and Long-Term Toxicity after Planned Intraoperative Boost and Whole Breast Irradiation in High-Risk Patients with Breast Cancer—Results from the Targeted Intraoperative Radiotherapy Boost Quality Registry (TARGIT BQR) Open
In the context of breast cancer treatment optimization, this study prospectively examines the feasibility and outcomes of utilizing intraoperative radiotherapy (IORT) as a boost in combination with standard external beam radiotherapy (EBRT…
View article: Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study
Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study Open
Adjuvant treatment of patients with early-stage breast cancer (BC) should include an aromatase inhibitor (AI). Especially patients with a high recurrence risk might benefit from an upfront therapy with an AI for a minimum of five years. Ne…
View article: Correction: Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study
Correction: Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study Open
[This corrects the article DOI: 10.1055/a-2238-3153.].
View article: Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study
Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study Open
Adjuvant treatment of patients with early-stage breast cancer (BC) should include an aromatase inhibitor (AI). Especially patients with a high recurrence risk might benefit from an upfront therapy with an AI for a minimum of five years. Ne…
View article: The effectiveness of integrated online health-coaching on physical activity and excessive gestational weight gain: a prospective randomized-controlled trial
The effectiveness of integrated online health-coaching on physical activity and excessive gestational weight gain: a prospective randomized-controlled trial Open
Purpose Low levels of physical activity during pregnancy go along with increased risks for numerous health complications. We investigated whether an integrated lifestyle intervention leads to higher levels of physical activity and reduces …
View article: Laparoscopic Fertility-Sparing Surgery for Early Ovarian Malignancies
Laparoscopic Fertility-Sparing Surgery for Early Ovarian Malignancies Open
The demand for fertility-sparing surgery (FSS) has increased in the last decade due to increased maternal age, increased incidence of ovarian malignancies in younger patients, and technical advances in surgery. Data on oncological safety a…
View article: Intraoperative radiotherapy (IORT) of early breast cancer with low-energy x-rays in breast-conserving surgery
Intraoperative radiotherapy (IORT) of early breast cancer with low-energy x-rays in breast-conserving surgery Open
Purpose The aim of this study is to identify pre- and intraoperative factors indicating the feasibility of intraoperative radiotherapy (IORT) during breast-conserving surgery (BCS). Materials and methods From January 2018 to December 2019,…
View article: Inhibition of Replication Origins and ATR Synergistically Activates the Innate Immune System in Cancer Cells
Inhibition of Replication Origins and ATR Synergistically Activates the Innate Immune System in Cancer Cells Open
Sufficient numbers of activated replication origins are essential for successful DNA replication. While normal cells load replication origins in abundance to the genome, cancer cells often load fewer origins of replication due to genomic a…
View article: Major complications after intraoperative radiotherapy with low-energy x-rays in early breast cancer
Major complications after intraoperative radiotherapy with low-energy x-rays in early breast cancer Open
Purpose To describe and analyze major local complications after intraoperative radiotherapy (IORT) with low-energy x‑rays during breast-conserving surgery (BCS) in early breast cancer. Methods Ten women out of 408 who were treated with IOR…
View article: Longitudinal cosmetic outcome after planned IORT boost with low kV X-rays—monocentric results from the TARGIT BQR registry
Longitudinal cosmetic outcome after planned IORT boost with low kV X-rays—monocentric results from the TARGIT BQR registry Open
Patients from the prospective TARGIT BQR study treated with IORT boost and additional whole breast irradiation showed good or excellent cosmetic outcomes in most cases during 4 years of follow-up. These results add important information fo…
View article: Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer Open
The acquisition of mesenchymal traits is considered a hallmark of breast cancer progression. However, the functional relevance of epithelial-to-mesenchymal transition (EMT) remains controversial and context dependent. Here, we isolate epit…
View article: Prevalence of higher-grade dysplasia in persistently high-risk human papillomavirus positive, cytology negative women after introduction of the new cervical cancer screening in Germany
Prevalence of higher-grade dysplasia in persistently high-risk human papillomavirus positive, cytology negative women after introduction of the new cervical cancer screening in Germany Open
Purpose According to the recently implemented organized cervical cancer screening program in Germany, women older than 35 years with negative cytology but persistent high-risk human papilloma virus (hrHPV) infection > 12 months should be r…
View article: Microscopic, Macroscopic and Thermal Impact of Argon Plasma, Diode Laser, and Electrocoagulation on Ovarian Tissue
Microscopic, Macroscopic and Thermal Impact of Argon Plasma, Diode Laser, and Electrocoagulation on Ovarian Tissue Open
Our study hints at superior safety profiles of preciseAPC® and monopolar electrocoagulation compared to bipolar electrocoagulation, diode laser and forcedAPC® for ovarian laparoscopic surgery.
View article: Patient Preferences With Regard to Care Structures for Cervical or Vulvar Dysplasia in Certified Dysplasia Clinics in Germany
Patient Preferences With Regard to Care Structures for Cervical or Vulvar Dysplasia in Certified Dysplasia Clinics in Germany Open
Most women expect very timely appointments and result notifications. Moreover, they favor short travel times and continuity of care. The identified patient preferences should be considered to increase patient satisfaction and quality of ca…