Marcel Mertz
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View article: Correction: Mertz et al. Interdisciplinary Animal Research Ethics—Challenges, Opportunities, and Perspectives. Animals 2024, 14, 2896
Correction: Mertz et al. Interdisciplinary Animal Research Ethics—Challenges, Opportunities, and Perspectives. Animals 2024, 14, 2896 Open
In the original version [...]
View article: Ethics domains in full health technology assessment reports: an attempt to begin mapping the field
Ethics domains in full health technology assessment reports: an attempt to begin mapping the field Open
Introduction Health technology assessment (HTA) reports are written for healthcare decision makers, particularly in relation to reimbursement/pricing, and are intended to assess clinical effectiveness, safety, and cost. Four additional dom…
View article: Interdisciplinary Animal Research Ethics—Challenges, Opportunities, and Perspectives
Interdisciplinary Animal Research Ethics—Challenges, Opportunities, and Perspectives Open
Can nonhuman animals be used for the benefit of humans in a scientifically and morally justified manner and, if yes, how? Based on our own experiences as scholars from various academic backgrounds, we argue that this question can only be a…
View article: Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Biomedical Research? A Spectrum of Ethically Relevant Reasons and Their Evaluation
Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Biomedical Research? A Spectrum of Ethically Relevant Reasons and Their Evaluation Open
Background: Research model selection decisions in basic and preclinical biomedical research have not yet been the subject of an ethical investigation. Therefore, this paper aims, (1) to identify a spectrum of reasons for choosing between a…
View article: Review of: "Categories of Wrong Beliefs—A Preliminary Proposal"
Review of: "Categories of Wrong Beliefs—A Preliminary Proposal" Open
Potential competing interests: No potential competing interests to declare.This brief communication deals with an important topic and pursues an interesting approach; the typology created is, at first glance, applicable and useful.Further …
View article: Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Research? A Spectrum of Reasons and Their Ethical Evaluation
Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Research? A Spectrum of Reasons and Their Ethical Evaluation Open
Background: Little is known about the decisional background of choosing an appropriate disease model. Therefore, this paper aims, (1) to identify a spectrum of reasons for choosing between animal and non-animal disease models and (2) provi…
View article: From book to bedside? A critical perspective on the debate about “translational bioethics”
From book to bedside? A critical perspective on the debate about “translational bioethics” Open
The concept of “translational bioethics” has received considerable attention in recent years. Most publications draw an analogy to translational medicine and describe bioethical research that aims at implementing and evaluating ethical int…
View article: Correction: What can the citations of systematic reviews of ethical literature tell us about their use?—an explorative empirical analysis of 31 reviews
Correction: What can the citations of systematic reviews of ethical literature tell us about their use?—an explorative empirical analysis of 31 reviews Open
Background Systematic reviews of ethical literature (SREL) aim at providing an overview of ethical issues, arguments, or concepts on a specific ethical topic.As SREL are becoming more common, their methodology and possible impact are incre…
View article: What can the citations of systematic reviews of ethical literature tell us about their use?—an explorative empirical analysis of 31 reviews
What can the citations of systematic reviews of ethical literature tell us about their use?—an explorative empirical analysis of 31 reviews Open
Background Systematic reviews of ethical literature (SREL) aim at providing an overview of ethical issues, arguments, or concepts on a specific ethical topic. As SREL are becoming more common, their methodology and possible impact are incr…
View article: Values, decision-making and empirical bioethics: a conceptual model for empirically identifying and analyzing value judgements
Values, decision-making and empirical bioethics: a conceptual model for empirically identifying and analyzing value judgements Open
It can be assumed that value judgements, which are needed to judge what is ‘good’ or ‘better’ and what is ‘bad’ or ‘worse’, are involved in every decision-making process. The theoretical understanding and analysis of value judgements is, t…
View article: Transformative medical ethics: A framework for changing practice according to normative–ethical requirements
Transformative medical ethics: A framework for changing practice according to normative–ethical requirements Open
We propose a step‐by‐step methodological framework of translational bioethics that aims at changing medical practice according to normative–ethical requirements, which we will thus call “transformative medical ethics.” The framework become…
View article: What can the citations of systematic reviews of ethical literature tell us about their use? - An explorative empirical analysis of 31 reviews
What can the citations of systematic reviews of ethical literature tell us about their use? - An explorative empirical analysis of 31 reviews Open
Background: Systematic reviews of ethical literature (SREL) aim at providing an overview of ethical issues, arguments or concepts on a specific ethical topic. As SREL are expanding, their methodology and possible impact are increasingly su…
View article: How to derive ethically appropriate recommendations for action? A methodology for applied ethics
How to derive ethically appropriate recommendations for action? A methodology for applied ethics Open
Researchers in applied ethics, and some areas of bioethics particularly, aim to develop concrete and appropriate recommendations for action in morally relevant real-world situations. When proceeding from more abstract levels of ethical rea…
View article: Risk assessment in gene therapy and somatic genome-editing: An expert interview study
Risk assessment in gene therapy and somatic genome-editing: An expert interview study Open
Innovation in gene therapy and genome editing raises high expectations for therapeutic breakthroughs. With the increasing maturity of the field, gene products using "gene transfer" technology, such as viral vectors, designer nucleases, inc…
View article: Additional treatment with mistletoe extracts for patients with breast cancer compared to conventional cancer therapy alone – efficacy and safety, costs and cost-effectiveness, patients and social aspects, and ethical assessment
Additional treatment with mistletoe extracts for patients with breast cancer compared to conventional cancer therapy alone – efficacy and safety, costs and cost-effectiveness, patients and social aspects, and ethical assessment Open
Background: Chemotherapy is often used in the treatment of breast cancer in women. Side effects such as diarrhea, fatigue, hair loss, fever or disturbances in blood formation impair the women’s quality of life. An essential treatment goal …
View article: Risk Assessment in Gene Therapy and Somatic Genome-Editing: An Expert Interview Study
Risk Assessment in Gene Therapy and Somatic Genome-Editing: An Expert Interview Study Open
Background: Innovation in gene therapy and genome editing raises high expectations for therapeutic breakthroughs. With increasing maturity of the field, gene products using “gene transfer” technology, such as viral vectors, designer nuclea…
View article: PRISMA-Ethics – Reporting Guideline for Systematic Reviews on Ethics Literature: development, explanations and examples
PRISMA-Ethics – Reporting Guideline for Systematic Reviews on Ethics Literature: development, explanations and examples Open
Systematic reviews (SR) are very well elaborated and established for synthesizing statistical information, for example of clinical studies, for determining whether a clinical intervention is effective. SRs are also becoming more and more p…
View article: Systematic reviews of empirical literature on bioethical topics: Results from a meta-review
Systematic reviews of empirical literature on bioethical topics: Results from a meta-review Open
Background In bioethics, especially nursing ethics, systematic reviews are increasingly popular. The overall aim of a systematic review is to provide an overview of the published discussions on a specific topic. While a meta-review on syst…
View article: How to tackle the conundrum of quality appraisal in systematic reviews of normative literature/information? Analysing the problems of three possible strategies (translation of a German paper)
How to tackle the conundrum of quality appraisal in systematic reviews of normative literature/information? Analysing the problems of three possible strategies (translation of a German paper) Open
Background In the last years, there has been an increase in publication of systematic reviews of normative (“argument-based”) literature or of normative information (such as ethical issues) in bioethics. The aim of a systematic review is t…
View article: The value of bioethical research: A qualitative literature analysis of researchers’ statements
The value of bioethical research: A qualitative literature analysis of researchers’ statements Open
Even though limitations arise regarding the sample, the study revealed a plethora of value dimensions that can inform further debates about what makes bioethical research valuable for science and society. Besides theoretical reflections on…
View article: The Full Spectrum of Clinical Ethical Issues in Kidney Failure. Findings of a Systematic Qualitative Review
The Full Spectrum of Clinical Ethical Issues in Kidney Failure. Findings of a Systematic Qualitative Review Open
BackgroundWhen treating patients with kidney failure, unavoidable ethical issues often arise. Current clinical practice guidelines some of them, but lack comprehensive information about the full range of relevant ethical issues in kidney f…
View article: Representation of 31 DSEIs in 12 national clinical practice guidelines on dementia care.
Representation of 31 DSEIs in 12 national clinical practice guidelines on dementia care. Open
Rating modalities: N, not addressed; I, implicitly addressed; E, explicitly addressed without recommendation; R, explicitly addressed with recommendation including: justification/citation, +/+; justification/no citation, +/−; no justificat…