Marcel R. de Zoete
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View article: Identification of multiple serine hydrolases involved in virulence and cell envelope integrity of Klebsiella pneumoniae
Identification of multiple serine hydrolases involved in virulence and cell envelope integrity of Klebsiella pneumoniae Open
Klebsiella pneumoniae is a resident of the human gastro-intestinal tract and an opportunistic, critical priority pathogen that can cause severe systemic infections. To overcome emerging multi-drug resistance, discovery and validation of no…
View article: CLR-Seq: a pipeline to identify bacterial microbiota species with immune-relevant glycan moieties through human C-type lectin receptor interaction
CLR-Seq: a pipeline to identify bacterial microbiota species with immune-relevant glycan moieties through human C-type lectin receptor interaction Open
Bacterial glycans are key components in immune interactions. We lack insight into the diverse glycan landscape present in complex microbial communities since currentomics techniques do not capture this post-translational information. Here …
View article: <i>Fusobacterium nucleatum</i> upregulates the immune inhibitory receptor <i>PD-L1</i> in colorectal cancer cells via the activation of ALPK1
<i>Fusobacterium nucleatum</i> upregulates the immune inhibitory receptor <i>PD-L1</i> in colorectal cancer cells via the activation of ALPK1 Open
Fusobacterium nucleatum is a Gram-negative oncobacterium that is associated with colorectal cancer. The molecular mechanisms utilized by F. nucleatum to promote colorectal tumor development have largely focused on adhesin-med…
View article: Omnigene-Guttm ensures fecal microbiome stability in the pediatric population
Omnigene-Guttm ensures fecal microbiome stability in the pediatric population Open
Increasing evidence exists that the gut microbiome influences toxicity as well as outcomes in a variety of cancers. To investigate the role of the gut microbiome in pediatric neuro-oncology, microbiome analysis has been included in multipl…
View article: Next-generation IgA-SEQ allows for high-throughput, anaerobic, and metagenomic assessment of IgA-coated bacteria
Next-generation IgA-SEQ allows for high-throughput, anaerobic, and metagenomic assessment of IgA-coated bacteria Open
Our magnetic 96-well plate-based high-throughput next-generation IgA-SEQ technology efficiently identifies a great number of IgA-coated bacteria from fecal samples. This paves the way for analyzing large cohorts as well as novel downstream…
View article: Activity-Based Protein Profiling Identifies<i>Klebsiella pneumoniae</i>Serine Hydrolases with Potential Roles in Host-Pathogen Interactions
Activity-Based Protein Profiling Identifies<i>Klebsiella pneumoniae</i>Serine Hydrolases with Potential Roles in Host-Pathogen Interactions Open
Klebsiella pneumoniae is a normal resident of the human gastro-intestinal tract and an opportunistic, critical priority pathogen that can cause a variety of severe systemic infections. Due to emerging multi-drug resistance of this pathogen…
View article: Dietary cystine restriction increases the proliferative capacity of the small intestine of mice
Dietary cystine restriction increases the proliferative capacity of the small intestine of mice Open
Currently, over 88 million people are estimated to have adopted a vegan or vegetarian diet. Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary intake of meat, eggs and whole grains. Vegan/vegetarian…
View article: Advanced Technologies for Studying Microbiome–Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond
Advanced Technologies for Studying Microbiome–Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond Open
The female reproductive tract (FRT) is home to diverse microbial communities that play a pivotal role in reproductive health and disorders such as infertility, endometriosis, and cervical cancer. To understand the complex host–microbiota i…
View article: Dietary cystine restriction increases the proliferative capacity of the small intestine of mice
Dietary cystine restriction increases the proliferative capacity of the small intestine of mice Open
Over 88 million people are currently estimated to have adopted towards a vegan or vegetarian diet. Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary intake of meat, eggs and whole grains. Vegan/veg…
View article: The Role of Microbiota-Derived Metabolites in Colorectal Cancer
The Role of Microbiota-Derived Metabolites in Colorectal Cancer Open
The impact of bacterial members of the microbiota on the development of colorectal cancer (CRC) has become clear in recent years. However, exactly how bacteria contribute to the development of cancer is often still up for debate. The impac…
View article: Allobaculum mucilyticum sp. nov. and Allobaculum fili sp. nov., isolated from the human intestinal tract
Allobaculum mucilyticum sp. nov. and Allobaculum fili sp. nov., isolated from the human intestinal tract Open
As part of a culturomics study to identify bacterial species associated with inflammatory bowel disease, a large collection of bacteria was isolated from patients with ulcerative colitis. Two of these isolates were tentatively identified a…
View article: Interspecies commensal interactions have nonlinear impacts on host immunity
Interspecies commensal interactions have nonlinear impacts on host immunity Open
View article: Ablation of liver Fxr results in an increased colonic mucus barrier in mice
Ablation of liver Fxr results in an increased colonic mucus barrier in mice Open
View article: The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells
The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells Open
The Gram-negative bacterium Campylobacter jejuni is a major cause of foodborne disease in humans. After infection, C . jejuni rapidly colonizes the mucus layer of the small and large intestine and induces a potent pro-inflammatory response…
View article: Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients
Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients Open
View article: Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader
Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader Open
The human gut microbiota plays a central role in intestinal health and disease. Yet, many of its bacterial constituents are functionally still largely unexplored. A crucial prerequisite for bacterial survival and proliferation is the creat…
View article: Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease
Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease Open
View article: Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages
Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages Open
Interferon (IFN)-inducible guanylate binding proteins (GBPs) mediate cell-autonomous host resistance to bacterial pathogens and promote inflammasome activation. The prevailing model postulates that these two GBP-controlled activities are d…
View article: Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients
Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients Open
Background: In Behçet's disease (BD), an auto-inflammatory vasculitis, an unbalanced gut microbiota can contribute to pro-inflammatory reactions. In separate studies, distinct pro- and anti-inflammatory bacteria associated with BD h…
View article: Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity Open
View article: Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity Open
View article: Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity Open
View article: Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response Open
Stressed gut epithelium gets some relief Immunoglobulin A (IgA) is the most abundantly expressed antibody isotype and can be found at various mucosal surfaces in the body, including the gastrointestinal (GI) tract. IgA is polyreactive and …
View article: Interleukin‐17/interleukin‐17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high‐fat diet‐induced metabolic syndrome model
Interleukin‐17/interleukin‐17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high‐fat diet‐induced metabolic syndrome model Open
Summary Sound evidence supports a role for interleukin‐17 (IL‐17) ‐producing γδ T cells and IL‐17‐producing helper T (Th17) cells in intestinal homeostasis, especially in intestinal barrier integrity. In the present study, we aimed to eval…
View article: NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease Open
View article: Interleukin‐23 promotes intestinal T helper type17 immunity and ameliorates obesity‐associated metabolic syndrome in a murine high‐fat diet model
Interleukin‐23 promotes intestinal T helper type17 immunity and ameliorates obesity‐associated metabolic syndrome in a murine high‐fat diet model Open
Summary We addressed the role of interleukin‐23 ( IL ‐23) in driving the intestinal T helper type 17 (Th17) response during obesity and metabolic syndrome progression induced by a high‐fat diet ( HFD ). Diet‐induced obese and lean mice rec…
View article: Humanized mouse model supports development, function, and tissue residency of human natural killer cells
Humanized mouse model supports development, function, and tissue residency of human natural killer cells Open
Significance Humanized mice represent a promising approach to study the human immune system in health and disease. However, insufficient development and function of human lymphocytes limit the applicability of humanized mice for cancer bio…
View article: Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation
Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation Open
Inflammasomes play a central role in regulating intestinal barrier function and immunity during steady state and disease. Because the discoveries of a passenger mutation and a colitogenic microbiota in the widely used caspase-1-deficient m…
View article: Invasive behavior of<i>Campylobacter jejuni</i>in immunosuppressed chicken
Invasive behavior of<i>Campylobacter jejuni</i>in immunosuppressed chicken Open
Campylobacter jejuni is a predominant cause of gastroenteritis in humans but rather harmless in chickens. The basis of this difference is unknown. We investigated the effect of the chicken immune defense on the behavior of C. jejuni using …
View article: Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset
Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset Open
Type 1 diabetes (T1D) is an autoimmune disease that is triggered by both genetic and environmental factors, resulting in the destruction of pancreatic β cells. The disruption of the intestinal epithelial barrier and consequent escape of mi…