Marcel Schrader
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View article: Highly parallel bending tests for fungal hyphae enabled by two-photon polymerization of microfluidic mold
Highly parallel bending tests for fungal hyphae enabled by two-photon polymerization of microfluidic mold Open
Filamentous microorganisms exhibit a complex macro-morphology constituted of branched and cross-linked hyphae. Fully resolved mechanical models of such mycelial compounds rely heavily on accurate input data for mechanical properties of ind…
View article: Simulation of the compression of pellets out of filamentous microorganisms using DEM
Simulation of the compression of pellets out of filamentous microorganisms using DEM Open
Filamentous microorganisms enable the production of a wide range of industrially relevant substances, such as enzymes or active pharmaceutical ingredients, from renewable side products and waste materials. The microorganisms' growth is cha…
View article: Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions
Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions Open
In biotechnological processes, filamentous microorganisms are known for their broad product spectrum and complex cellular morphology. Product formation and cellular morphology are often closely linked, requiring a well-defined level of mec…
View article: Morphology engineering for novel antibiotics: Effect of glass microparticles and soy lecithin on rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes
Morphology engineering for novel antibiotics: Effect of glass microparticles and soy lecithin on rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes Open
Lentzea aerocolonigenes , as an actinomycete, is a natural producer of the antibiotic and antitumoral drug rebeccamycin. Due to the filamentous cellular morphology handling in cultivations is challenging; therefore, morphology engineering …
View article: Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms
Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms Open
Filamentous microorganisms are used as molecular factories in industrial biotechnology. In 2007, a new approach to improve productivity in submerged cultivation was introduced: microparticle‐enhanced cultivation (MPEC). Since then, numerou…
View article: Macroparticle‐enhanced cultivation of <i>Lentzea aerocolonigenes</i>: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production
Macroparticle‐enhanced cultivation of <i>Lentzea aerocolonigenes</i>: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production Open
The actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. In previous studies the rebeccamycin production was significantly increased by the addition of glass beads during cultivation in different diameters b…
View article: Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production
Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production Open
The actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. In previous studies the rebeccamycin production was significantly increased by the addition of glass beads during cultivation in different diameters b…
View article: Grinding Media Motion and Collisions in Different Zones of Stirred Media Mills
Grinding Media Motion and Collisions in Different Zones of Stirred Media Mills Open
Product fineness during grinding in stirred media mills is mainly influenced by the specific energy input, the stress energy transferred by the colliding grinding media and the stress frequency. The stress energy from grinding media collis…
View article: Morphological and physiological characterization of filamentous Lentzea aerocolonigenes: Comparison of biopellets by microscopy and flow cytometry
Morphological and physiological characterization of filamentous Lentzea aerocolonigenes: Comparison of biopellets by microscopy and flow cytometry Open
Cell morphology of filamentous microorganisms is highly interesting during cultivations as it is often linked to productivity and can be influenced by process conditions. Hence, the characterization of cell morphology is of major importanc…
View article: Particle based Cultivation of Lentzea aerocolonigenes in Membrane aerated stirred Bioreactors for increased Rebeccamycin Production
Particle based Cultivation of Lentzea aerocolonigenes in Membrane aerated stirred Bioreactors for increased Rebeccamycin Production Open
Filamentous microorganisms represent the majority of natural producers of antibiotics and other active pharmaceutical ingredients (APIs). Lentzea aerocolonigenes is a filamentous actinomycete producing the antitumor antibiotic rebeccamycin…