Marcel Simon
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View article: Comparison of the Equivalence of <i>Aspergillus</i> Antigen and <scp>PCR</scp> Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients
Comparison of the Equivalence of <i>Aspergillus</i> Antigen and <span>PCR</span> Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients Open
Background Obtaining non‐directed samples from the upper bronchial tree is easier to perform and poses fewer risks for critically ill patients than deep bronchoalveolar lavage (BAL). Since invasive pulmonary aspergillosis is associated wit…
View article: P0706 Dose intensification of subcutaneous vedolizumab is an effective and safe option in Inflammatory Bowel Disease patients: Results from the multicentre OPTI-VEDO study
P0706 Dose intensification of subcutaneous vedolizumab is an effective and safe option in Inflammatory Bowel Disease patients: Results from the multicentre OPTI-VEDO study Open
Background Subcutaneous (SC) vedolizumab (VDZ) has demonstrated its efficacy and safety in patients with moderate-to-severe ulcerative colitis (UC) and Crohn’s disease (CD). This study aimed to evaluate the effectiveness and safety of SC V…
View article: Comparison of four diagnostic criteria for invasive pulmonary aspergillosis—A diagnostic accuracy study in critically ill patients
Comparison of four diagnostic criteria for invasive pulmonary aspergillosis—A diagnostic accuracy study in critically ill patients Open
Background In the absence of lung biopsy, there are various algorithms for the diagnosis of invasive pulmonary aspergillosis (IPA) in critically ill patients that rely on clinical signs, underlying conditions, radiological features and myc…
View article: Diagnostic Utility of Bronchoalveolar Lavage in Patients with Acute Leukemia under Broad-Spectrum Anti-Infective Treatment
Diagnostic Utility of Bronchoalveolar Lavage in Patients with Acute Leukemia under Broad-Spectrum Anti-Infective Treatment Open
Despite therapeutic advances in the prevention and treatment of febrile neutropenia, acute leukemia (AL) patients still have considerable febrile neutropenia-related mortality. However, the diagnostic yield of flexible bronchoscopy (FB) an…
View article: Comparison of four diagnostic criteria for invasive pulmonary aspergillosis – a diagnostic accuracy study in critically ill patients
Comparison of four diagnostic criteria for invasive pulmonary aspergillosis – a diagnostic accuracy study in critically ill patients Open
BACKGROUND: In the absence of lung biopsy there are various algorithms for the diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients that rely on clinical signs, underlying conditions, radiological featu…
View article: Management of Esophageal Cancer-Associated Respiratory–Digestive Tract Fistulas
Management of Esophageal Cancer-Associated Respiratory–Digestive Tract Fistulas Open
Respiratory–digestive tract fistulas are fatal complications that occur in esophageal cancer treatment. Interdisciplinary treatment strategies are still evolving, especially in anatomical treatment stratification. Thus, this study aims to …
View article: Comparison of Four Diagnostic Criteria for Invasive Pulmonary Aspergillosis – A Diagnostic Accuracy Study in Critically Ill Patients
Comparison of Four Diagnostic Criteria for Invasive Pulmonary Aspergillosis – A Diagnostic Accuracy Study in Critically Ill Patients Open
BACKGROUND: In the absence of lung biopsy there are various algorithms for the diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients that rely on clinical signs, underlying conditions, radiological featu…
View article: Respiratory Muscle Dysfunction in COVID-19 Patients with Persistent Symptoms
Respiratory Muscle Dysfunction in COVID-19 Patients with Persistent Symptoms Open
In a cross-sectional analysis, we have identified a high prevalence of respiratory muscle dysfunction in persistently symptomatic patients after COVID-19 (‘Long COVID’). Respiratory muscle impairment in these patients was associated with e…
View article: Additional file 2 of Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study
Additional file 2 of Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study Open
Additional file 2: Table S1. Detailed information on the IV used in the MR analyses. Table S2. Intercept from Egger-regression analyses. Table S3. Results from single SNP MR based on the ratio estimate and from leave-one-out MR based on th…
View article: Granulomatosis with polyangiitis: mind the airway
Granulomatosis with polyangiitis: mind the airway Open
Key message Granulomatosis with polyangiitis (GPA) is a potentially life‐threatening disease that affects all ages. As the disease may be rapidly progressive, the undelayed recognition of its inflammatory activity is critical. This is espe…
View article: Endotracheal tube-mounted camera-assisted intubation versus conventional intubation in intensive care: a prospective, randomised trial (VivaITN)
Endotracheal tube-mounted camera-assisted intubation versus conventional intubation in intensive care: a prospective, randomised trial (VivaITN) Open
ClinicalTrials.gov, NCT02837055 . Registered on 13 June 2016.
View article: Endoscopic lung volume reduction coil treatment in patients with very low FEV<sub>1</sub>: an observational study
Endoscopic lung volume reduction coil treatment in patients with very low FEV<sub>1</sub>: an observational study Open
Background: Endoscopic lung volume reduction coil (LVRC) treatment is a therapeutic option for selected patients with advanced emphysema. The effects and the safety of endoscopic lung volume reduction in patients with very low forced expir…
View article: Bronchoscopy versus an endotracheal tube mounted camera for the peri-interventional visualization of percutaneous dilatational tracheostomy - a prospective, randomized trial (VivaPDT)
Bronchoscopy versus an endotracheal tube mounted camera for the peri-interventional visualization of percutaneous dilatational tracheostomy - a prospective, randomized trial (VivaPDT) Open
ClinicalTrials.gov, NCT02861001 . Registered on 13 June 2016.
View article: Endoscopic lung volume reduction coil treatment in patients with chronic hypercapnic respiratory failure: an observational study
Endoscopic lung volume reduction coil treatment in patients with chronic hypercapnic respiratory failure: an observational study Open
Background: Endoscopic lung volume reduction coil (LVRC) treatment is an option for selected patients with severe emphysema. In the advanced stages, emphysema leads to respiratory failure: hypoxemia and eventually chronic hypercapnic respi…
View article: High-Flow Nasal Cannula Versus Bag-Valve-Mask for Preoxygenation Before Intubation in Subjects With Hypoxemic Respiratory Failure
High-Flow Nasal Cannula Versus Bag-Valve-Mask for Preoxygenation Before Intubation in Subjects With Hypoxemic Respiratory Failure Open
Preoxygenation using HFNC before intubation was feasible and safe compared with BVM in critically ill subjects with acute, mild to moderate hypoxemic respiratory failure. There was no significant difference in the mean lowest SpO2 during i…
View article: Does galactomannan testing increase diagnostic accuracy for IPA in the ICU? A prospective observational study
Does galactomannan testing increase diagnostic accuracy for IPA in the ICU? A prospective observational study Open
The study was registered at ClinicalTrials.gov (registration number NCT01866020 ) on 27 May 2013.
View article: Value of Computed Tomography of the Chest in Subjects With ARDS: A Retrospective Observational Study
Value of Computed Tomography of the Chest in Subjects With ARDS: A Retrospective Observational Study Open
Systematic evaluation of thoracic CT scans yielded information useful for making a diagnosis, predicting prognosis, and recognizing concomitant disorders requiring therapeutic interventions. Results obtained from CT scans led to changes in…
View article: HIGH FLOW NASAL CANNULA OXYGEN VS. BAG-VALVE-MASK FOR PREOXYGENATION BEFORE INTUBATION IN PATIENTS WITH HYPOXEMIC RESPIRATORY FAILURE - A PROSPECTIVE RANDOMIZED TRIAL
HIGH FLOW NASAL CANNULA OXYGEN VS. BAG-VALVE-MASK FOR PREOXYGENATION BEFORE INTUBATION IN PATIENTS WITH HYPOXEMIC RESPIRATORY FAILURE - A PROSPECTIVE RANDOMIZED TRIAL Open
Scheduled endotracheal intubation for elective surgery is generally considered a safe procedure. In contrast, critically ill patients in the intensive care unit (ICU), especially those with respiratory failure, have an increased risk for h…