Marcel Tomaszewski
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View article: Small molecules targeting Progranulin as potential therapeutics for Frontotemporal Dementia (FTD) and other dementias
Small molecules targeting Progranulin as potential therapeutics for Frontotemporal Dementia (FTD) and other dementias Open
Background Progranulin ( GRN ) plays a critical role in familial frontotemporal dementia (fFTD), where GRN haploinsufficiency leads to reduction in PGRN levels in the brain, resulting in degeneration of neurons in the frontal lobe of brain…
View article: Patient and provider perspectives on telemedicine use in Canadian gastroenterology clinics during the COVID-19 pandemic: a survey study
Patient and provider perspectives on telemedicine use in Canadian gastroenterology clinics during the COVID-19 pandemic: a survey study Open
Background Telemedicine has revolutionized access to medical care. This was particularly palpable during the COVID pandemic and within gastroenterology. Telehealth can improve access to patients remotely, and lead to high patient and clini…
View article: Cardiac Septal Occluder for Refractory Anastamotic Leak
Cardiac Septal Occluder for Refractory Anastamotic Leak Open
Figure 1.(A) A 5-mm fistula tract was identified at the esophagojejunal anastomosis.(B and C) A 9-mm waisted Amplatzer septal occluder was deployed across the fistula tract beside the endoscope under fluoroscopic (B) and endoscopic guidanc…
View article: Impact of Telehealth on Medication Adherence in Chronic Gastrointestinal Diseases
Impact of Telehealth on Medication Adherence in Chronic Gastrointestinal Diseases Open
Background With the COVID-19 pandemic, the demand and availability of telehealth in outpatient care has had exponential growth. Although use of telehealth has been studied and validated for various medical specialties, relatively few studi…
View article: A256 SURVEILLANCE OF SMALL, NON-FUNCTIONING, ASYMPTOMATIC PANCREATIC NEUROENDOCRINE TUMORS: THE BRITISH COLUMBIA EXPERIENCE
A256 SURVEILLANCE OF SMALL, NON-FUNCTIONING, ASYMPTOMATIC PANCREATIC NEUROENDOCRINE TUMORS: THE BRITISH COLUMBIA EXPERIENCE Open
Background Expert consensus surrounding surveillance for small, non-functioning, asymptomatic pancreatic neuroendocrine tumors (PNETs) remains conflicting. Recent observational studies have shown that surveillance is a safe strategy while …
View article: A90 WHEN DO TRAINEES ACHIEVE COMPETENCY IN PERFORMING ENDOSCOPIC SUBMUCOSAL DISSECTION: A SYSTEMATIC REVIEW
A90 WHEN DO TRAINEES ACHIEVE COMPETENCY IN PERFORMING ENDOSCOPIC SUBMUCOSAL DISSECTION: A SYSTEMATIC REVIEW Open
Background Endoscopic submucosal dissection (ESD) is an established organ sparing curative endoscopic resection technique for the management of pre-malignant and superficially invasive malignant lesions of the gastrointestinal tract. Howev…
View article: A126 ONCE IS BY CHANCE, TWO IS A TREND: A RECURRING FINDING WITHIN THE POST-RESECTION DEFECT
A126 ONCE IS BY CHANCE, TWO IS A TREND: A RECURRING FINDING WITHIN THE POST-RESECTION DEFECT Open
Background A 74-year-old male was referred for the management of a large non-pedunculated colorectal polyp in the transverse colon. On optical evaluation, including high-definition white-light and narrow-band imaging (NBI), a 30mm 0-IIA no…
View article: Risks associated with colonoscopy in a population-based colon screening program: an observational cohort study
Risks associated with colonoscopy in a population-based colon screening program: an observational cohort study Open
The rate of serious adverse events associated with colonoscopy in the BCCSP was in keeping with previous publications and met accepted benchmarks. The findings of this study inform stakeholders of the risks associated with colonoscopy in a…
View article: Hepatic steatosis as measured by the computed attenuation parameter predicts fibrosis in long-term methotrexate use
Hepatic steatosis as measured by the computed attenuation parameter predicts fibrosis in long-term methotrexate use Open
INTRODUCTION: To determine predictors of hepatic steatosis by the computed attenuation parameter (CAP) and fibrosis via transient elastography (TE) in persons on methotrexate (MTX) therapy with rheumatologic and dermatologic diseases. METH…
View article: A239 AN APPROACH TO GASTRIC BALLOON RETRIEVAL ADMIDST COVID-19 RELATED TRAVEL RESTRICTIONS
A239 AN APPROACH TO GASTRIC BALLOON RETRIEVAL ADMIDST COVID-19 RELATED TRAVEL RESTRICTIONS Open
Background Given the COVID-19 pandemic, international travel restrictions have been in effect since March 2020 in Canada. As a result, some patients requiring international travel for medical care have experienced delays. Therefore, innova…
View article: A83 IMPACT OF TELEHEALTH ON MEDICATION ADHERENCE IN GASTROENTEROLOGY CHRONIC DISEASE MANAGEMENT
A83 IMPACT OF TELEHEALTH ON MEDICATION ADHERENCE IN GASTROENTEROLOGY CHRONIC DISEASE MANAGEMENT Open
Background With the COVID-19 pandemic, the demand and availability of telehealth in outpatient care has increased. Although use of telehealth has been studied and validated for various medical specialties, relatively few studies have looke…
View article: A88 PATIENT AND PHYSICIAN PERSPECTIVE OF TELE-HEALTH IN GASTROENTEROLOGY
A88 PATIENT AND PHYSICIAN PERSPECTIVE OF TELE-HEALTH IN GASTROENTEROLOGY Open
Background Given the social distancing measures employed to reduce the transmission of SARS-CoV-2, tele-health has rapidly expanded and is now routinely used in new patient encounters and in follow up appointments across Canada. Aims To de…
View article: Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure Open
Although hepatic involvement in light chain–associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man …
View article: Unusual formation of the musculocutaneous and median nerves: a case report refined by intraneural dissection and literature review
Unusual formation of the musculocutaneous and median nerves: a case report refined by intraneural dissection and literature review Open
This report presents a detailed anatomical investigation of an upper limb specimen showing an atypical formation of the musculocutaneous nerve (MCN) and median nerve (MN). The study was refined by intraneural dissection, which supplements …
View article: Hepatic steatosis predicts fibrosis in long-term methotrexate use
Hepatic steatosis predicts fibrosis in long-term methotrexate use Open
A137 COLONOSCOPY RELATED ADVERSE EVENTS IN A POPULATION-BASED COLON SCREENING PROGRAM Open
View article: A186 HEPATIC STEATOSIS PREDICTS FIBROSIS IN LONG-TERM METHOTREXATE USE
A186 HEPATIC STEATOSIS PREDICTS FIBROSIS IN LONG-TERM METHOTREXATE USE Open
Background Methotrexate (MTX) is effective for dermatologic and rheumatologic conditions such as psoriasis (Ps), psoriatic arthritis (PsO) and rheumatoid arthritis (RA). Long-term MTX use may be complicated by hepatic fibrosis, although pa…
A276 TOTAL PANCREATIC LIPOMATOSIS AND EXOCRINE PANCREATIC INSUFFICIENCY IN A PATIENT WITH CELIAC DISEASE: AN UNUSUAL ENTITY Open
A174 RARE BUT DEADLY: AN APPROACH TO MANAGEMENT OF DUODENAL VARICEAL HEMORRHAGE Open
View article: Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population‐based study
Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population‐based study Open
Background Esophageal cancer can be subdivided into two main histological subtypes with significant variability in their etiology and epidemiology. The incidence of esophageal adenocarcinoma (AC) is increasing across the developed countrie…
View article: Transhepatic PEG Tube Placement
Transhepatic PEG Tube Placement Open
View article: A245 TRANSHEPATIC PEG-TUBE INSERTION: A CASE REPORT AND REVIEW OF THE LITERATURE
A245 TRANSHEPATIC PEG-TUBE INSERTION: A CASE REPORT AND REVIEW OF THE LITERATURE Open
BACKGROUND: Minor complications of percutaneous endoscopic gastrostomy (PEG) tube insertion include infection, peristomal leakage, tube obstruction and transient ileus. Major complications such as bowel perforation, fistulae, bowel obstruc…
View article: Stem Cell Therapy in the Elderly with Liver Disease
Stem Cell Therapy in the Elderly with Liver Disease Open
There is evidence to suggest that older livers regenerate less well and display cellular senescence. Additionally, elderly patients with certain liver diseases have a less favourable course. Chronic liver disease, amongst the elderly, has …
View article: Severe pet-transmitted zoonosis in a patient with a compromised immune system
Severe pet-transmitted zoonosis in a patient with a compromised immune system Open
KEY POINTS A 76-year-old man originally from Barbados was admitted to hospital after experiencing one month of progressive generalized weakness that culminated in his inability to carry out independent activities of daily living. The patie…
View article: A209 ENDOSCOPY BLEEDING RISK IN PATIENTS WITH INHERITED COAGULATION DISORDERS, A RETROSPECTIVE STUDY
A209 ENDOSCOPY BLEEDING RISK IN PATIENTS WITH INHERITED COAGULATION DISORDERS, A RETROSPECTIVE STUDY Open
BACKGROUND: Hemophilia A and B and Von Willebrand Disease (VWD) are congenital bleeding disorders which respectively lead to factor VIII (F8) and factor IX (F9) deficiency and Von Willebrand Factor defects. Rarer bleeding disorders include…