Marcel Twickler
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Clustered cardiometabolic risk in pregnancy and dysmenorrhea in offspring: Results from a prospective birth cohort study Open
Background Dysmenorrhea, a common gynaecological complaint, is often underdiagnosed, particularly in adolescents. The Developmental Origins of Health and Disease hypothesis suggests that maternal cardiometabolic conditions during pregnancy…
Cardiovascular biomarkers and preeclampsia: A narrative review Open
Background Preeclampsia is a disorder with complex pathophysiology, which underscores the need to study various biomarkers for its early prediction, accurate diagnosis, better understanding of underlying mechanisms and potential links to o…
View article: Maternal Factors During Pregnancy and Pubertal Timing in Offspring: A Systematic Review of the Literature
Maternal Factors During Pregnancy and Pubertal Timing in Offspring: A Systematic Review of the Literature Open
This review provides a comprehensive overview of the quality and consistency of existing evidence regarding maternal factors during pregnancy that may be associated with the pubertal timing in their offspring. This review may serve as an o…
Hypothyroidism During Immune Checkpoint Inhibitor Therapy That Is Not Responsive to Thyroxin Substitution. A Peripheral T4-T3 Conversion Block? Open
Hypothyroidism is a frequently occurring side effect in patients under treatment with immune checkpoint inhibitors. Recently, we were confronted with three patients who were treated with a checkpoint inhibitor expressing clinically overt h…
Low Health Literate State Does Not Negatively Affect Final Weight Loss After a Laparoscopic Gastric Bypass Procedure Open
Weight loss surgery is an effective treatment in patients with morbid obesity, but its benefit depends on self-care management afterwards Self-care management is partly influenced by individual’s health literacy. The level of individual’s …
Maternal Total Cortisol Levels in Early Pregnancy Depends on Fetal Sexual Dimorphism. But Finally No Association With Birth Weight Open
Enhanced maternal cortisol levels may have a negative impact on fetal development with a higher risk for diseases later in life, e.g. premature cardiovascular disease and type 2 diabetes. Prior studies do assume even a sex specific impact.…
Trials and tribulations of young residents fighting COVID‐19 Open
No one could foresee that an unknown novel virus far away in Asia eventually would end up as world's largest disaster. As days went by, COVID-19 soon began gaining international attention with its significant infectiousness, rapidly deteri…
Introduction: Finding a way in daily clinical practice during COVID‐19 pandemic Open
Since some months, the COVID-19 pandemic changed our world drastically. At the start of the pandemic, in a single week, our medical communities, both in primary care, nursing homes, as in secondary and tertiary facilities, have been forced…
SARS‐CoV‐2: What is known and what there is to know—Focus on coagulation and lipids Open
As the SARS-CoV2 pandemic is still progressing, dissemination of information has become of paramount importance. However, the rapid influx of SARS-CoV-2 patients in our hospitals has overwhelmed the time needed for appropriate information …
View article: Emerging cardiological issues during the COVID‐19 pandemic
Emerging cardiological issues during the COVID‐19 pandemic Open
Today the modern world is facing an unprecedented health crisis. The COVID-19 pandemic is putting extensive strain on healthcare systems hospitals and medical workers worldwide. Epidemiological data are emerging that COVID-19 patients with…
Diabetes or endocrinopathy admitted in the COVID‐19 ward Open
The Covid‐19 pandemic confronted us with unknown clinical pictures, also in diabetology and endocrinology. Sharing clinical experiences is therefore of enormous importance. Actually, information about the care given in the Covid‐19 ward (i…
The Cushing Reflex: Oliguria as a Reflection of an Elevated Intracranial Pressure Open
Oliguria is one of the clinical hallmarks of renal failure. The broad differential diagnosis is well known, but a rare cause of oliguria is intracranial hypertension (ICH). The actual knowledge to explain this relationship is scarce. Almos…
The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation Open
Synovial PRLR expression is enhanced in patients with inflammatory arthritis compared with OA, and PRL cooperates with other pro-inflammatory stimuli to activate macrophages. These results identify PRL and PRLR as potential new therapeutic…