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View article: Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease
Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease Open
This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient jo…
View article: CRISPR in Neurodegenerative Diseases Treatment: An Alternative Approach to Current Therapies
CRISPR in Neurodegenerative Diseases Treatment: An Alternative Approach to Current Therapies Open
Neurodegenerative diseases (NDs) pose a major challenge to global healthcare systems owing to their devastating effects and limited treatment options. These disorders are characterized by progressive loss of neuronal structure and function…
View article: From Amyloid to Synaptic Dysfunction: Biomarker-Driven Insights into Alzheimer’s Disease
From Amyloid to Synaptic Dysfunction: Biomarker-Driven Insights into Alzheimer’s Disease Open
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and represents a major public health challenge. With increasing life expectancy, the incidence of AD has also increased, highlighting the need for early diagnosis an…
View article: Urinary urodilatin levels in patients with renal salt wasting syndrome as a possible new diagnostic marker. A pilot study
Urinary urodilatin levels in patients with renal salt wasting syndrome as a possible new diagnostic marker. A pilot study Open
Background Renal Salt Wasting Syndrome (RSW) is a clinical syndrome with laboratory characteristics completely overlapping with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). No studies have yet investigated the pote…
View article: INFLAMMATORY ACTIVATION, EPIGENETIC SIGNATURE AND MORPHO-STRUCTURAL ALTERATION IN A COHORT OF PATIENTS WITH CHRONIC HEART FAILURE AND PERMANENT ATRIAL FIBRILLATION: A CROSS-SECTIONAL STUDY
INFLAMMATORY ACTIVATION, EPIGENETIC SIGNATURE AND MORPHO-STRUCTURAL ALTERATION IN A COHORT OF PATIENTS WITH CHRONIC HEART FAILURE AND PERMANENT ATRIAL FIBRILLATION: A CROSS-SECTIONAL STUDY Open
Background Atrial fibrillation (AF) is a complex disorder involving inflammatory, morpho-structural, and genetic factors. Emerging evidence suggests inflammation plays a pivotal role in AF initiation, maintenance, and outcomes. Methods We …
View article: New Frontiers in Nutritional and Therapeutic Interventions for Obesity Phenotypes
New Frontiers in Nutritional and Therapeutic Interventions for Obesity Phenotypes Open
The heterogeneity among patients with obesity is particularly evident in the weight loss response to interventions such as diets, drugs, devices and surgery. Obesity can be “catalogued” into four phenotypes: hungry brain (abnormal satiety …
View article: The Role of Killer Ig-like Receptors in Diseases from A to Z
The Role of Killer Ig-like Receptors in Diseases from A to Z Open
Killer Ig-like Receptors (KIRs) regulate immune responses, maintaining the balance between activation and inhibition of the immune system. KIRs are expressed on natural killer cells and some CD8 T cells and interact with HLA class I molecu…
View article: The value of midregional proadrenomedullin to predict mortality in intensive care unit
The value of midregional proadrenomedullin to predict mortality in intensive care unit Open
View article: Establishing Decisional Cutoff Values of Neurofilament Light Chains in Cerebrospinal Fluid Measured by Fully Automated Chemiluminescent Enzyme Immunoassay
Establishing Decisional Cutoff Values of Neurofilament Light Chains in Cerebrospinal Fluid Measured by Fully Automated Chemiluminescent Enzyme Immunoassay Open
Introduction Neurofilament light chain (NfL) is one of the most important biomarkers in the field of clinical neurochemistry. Several analytical methods have been developed in the last decade. Recently, Fujirebio introduced a ready‐to‐use …
View article: Evaluating the antioxidant, anti‐inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel ( <i>Morchella esculenta</i> L. Pers.)
Evaluating the antioxidant, anti‐inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel ( <i>Morchella esculenta</i> L. Pers.) Open
Scope This study aimed to assess the antioxidant, anti‐inflammatory, and acetylcholinesterase activities of fruiting bodies (FB) and mycelium (M) extracts of Morchella esculenta L . collected from various regions of Pakistan. The samples i…
View article: Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study
Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study Open
Studying models of healthy aging and exceptional longevity is crucial to understanding a possible longevity signature, as most show resistance to age-related diseases. In particular, semi- and supercentenarians are a highly selected group,…
View article: Neurobiological and Anti‐Inflammatory Effects of a Deep Diaphragmatic Breathing Technique Based on Neofunctional Psychotherapy: A Pilot RCT
Neurobiological and Anti‐Inflammatory Effects of a Deep Diaphragmatic Breathing Technique Based on Neofunctional Psychotherapy: A Pilot RCT Open
We examined the feasibility of using the neofunctional deep breathing (NDB) technique to reduce the allostatic load following the Trier Social Stress Test (TSST). Forty‐four healthy subjects were randomised into experimental and control gr…
View article: Evaluating the Impact of Novel Incretin Therapies on Cardiovascular Outcomes in Type 2 Diabetes: An Early Systematic Review
Evaluating the Impact of Novel Incretin Therapies on Cardiovascular Outcomes in Type 2 Diabetes: An Early Systematic Review Open
Background This systematic review is registered with CRD42024507397 protocol number and aims to compare the known data about retatrutide on long-term cardiovascular (CV) protection with tirzepatide, an incretin with recent proven CV benefi…
View article: Beyond the Gender Binarism: Neural Correlates of Trans Men in a Functional Connectivity–Resting-State fMRI Pilot Study
Beyond the Gender Binarism: Neural Correlates of Trans Men in a Functional Connectivity–Resting-State fMRI Pilot Study Open
Introduction: Several studies have investigated the specific neural correlates of trans people, highlighting mixed results. This study aimed to compare the presence of specific functional connectivity and differences in cognitive profile a…
View article: Cerebrospinal Fluid Neurofilaments Light-Chain Differentiate Patients Affected by Alzheimer’s Disease with Different Rate of Progression (RoP): A Preliminary Study
Cerebrospinal Fluid Neurofilaments Light-Chain Differentiate Patients Affected by Alzheimer’s Disease with Different Rate of Progression (RoP): A Preliminary Study Open
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and a leading cause of dementia. One major challenge for clinicians is accurately assessing the rate of disease progression (RoP) early in the diagnostic process, which…
View article: Complete Blood Count and Monocyte Distribution Width–Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study
Complete Blood Count and Monocyte Distribution Width–Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study Open
Background Sepsis is an organ dysfunction caused by a dysregulated host response to infection. Early detection is fundamental to improving the patient outcome. Laboratory medicine can play a crucial role by providing biomarkers whose alter…
View article: Do genetically determined very high and very low LDL levels contribute to Lp(a) plasma concentration?
Do genetically determined very high and very low LDL levels contribute to Lp(a) plasma concentration? Open
FH subjects exhibit higher Lp(a) levels than FHBL1 and general population. Lp(a) slightly contribute to hypercholesterolemia in FH patients. Subjects at high and very high CV risk exhibited significant higher Lp(a) levels compared with low…
View article: Evaluation of core Biomarkers of Alzheimer’s disease in saliva and plasma measured by chemiluminescent enzyme immunoassays on a fully automated platform
Evaluation of core Biomarkers of Alzheimer’s disease in saliva and plasma measured by chemiluminescent enzyme immunoassays on a fully automated platform Open
View article: Immune-Inflammatory Response in Lifespan. What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study
Immune-Inflammatory Response in Lifespan. What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study Open
Studying models of healthy aging and exceptional longevity is crucial to understand a possible longevity signature as most of them show resistance to age-related diseases. In particular, semi- and supercentenarians are a highly selected gr…
View article: Clinical usefulness of presepsin and monocyte distribution width (MDW) kinetic for predicting mortality in critically ill patients in intensive care unit
Clinical usefulness of presepsin and monocyte distribution width (MDW) kinetic for predicting mortality in critically ill patients in intensive care unit Open
Background In this study, we explored the accuracy of two new sepsis biomarkers, monocyte distribution width (MDW) and presepsin (PSP), compared to traditional ones, C-reactive protein (CRP) and Procalcitonin (PCT), to identify sepsis and …
View article: Evaluation of core Biomarkers of Alzheimer’s disease in saliva and plasma measured by chemiluminescent enzyme immunoassays on a fully automated platform
Evaluation of core Biomarkers of Alzheimer’s disease in saliva and plasma measured by chemiluminescent enzyme immunoassays on a fully automated platform Open
Background. Cerebrospinal fluid (CSF) core biomarkers of Alzheimer’s disease (AD), including amyloid peptide beta-42 (Aβ42), Aβ42/40 ratio, and phosphorylated tau (pTau), are precious tools for diagnosing AD. However, their use in clinical…
View article: Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice
Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice Open
Neurodegenerative disorders (NDs) represent a group of different diseases characterized by the progressive degeneration and death of the nervous system’s cells. The diagnosis is challenging, especially in the early stages, due to no specif…
View article: Metabolic dysfunction-associated fatty liver disease: current therapeutic strategies
Metabolic dysfunction-associated fatty liver disease: current therapeutic strategies Open
The definition of “Metabolic Associated Fatty Liver Disease – MAFLD” has replaced the previous definition of Nonalcoholic Fatty Liver Disease (NAFLD), because cardiometabolic criteria have been added for the prevention of cardiological ris…
View article: A machine learning strategy to mitigate the inappropriateness of procalcitonin request in clinical practice
A machine learning strategy to mitigate the inappropriateness of procalcitonin request in clinical practice Open
The ML models developed could represent a useful tool to predict PCT positivity, avoiding unusefulness PCT requests. ML models are based on laboratory tests commonly ordered together with PCT but have the great advantage to be easy to meas…
View article: Global hemostasis assays in acute myeloid leukemia: results of an observational prospective study.
Global hemostasis assays in acute myeloid leukemia: results of an observational prospective study. Open
Overall, TEG revealed complex and dynamic coagulation abnormalities in patients with AML according to both the course of disease and therapy. Further studies are needed to investigate more fully the role of TEG in defining the hemostatic p…
View article: The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity
The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity Open
In this paper, we present demographic, clinical, anamnestic, cognitive, and functional data, as well as haematological, haematochemical, immunological, and genetic parameters of an exceptional individual: A.T., a semi-supercentenarian who …
View article: Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity
Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity Open
Background The autonomic nervous system is linked to hyperdynamic circulation in cirrhosis and several studies have highlighted the crucial role that systemic inflammation elicits in altering sympathovagal equilibrium with the consequent r…
View article: The Phenotypic Characterization of the Oldest Italian Men from December 28, 2020 to September 23, 2021, Antonino Turturici, Suggests a Role for Immune System in the Attainment of Extreme Longevity
The Phenotypic Characterization of the Oldest Italian Men from December 28, 2020 to September 23, 2021, Antonino Turturici, Suggests a Role for Immune System in the Attainment of Extreme Longevity Open
In this paper, we present demographic, clinical, anamnestic, cognitive, and functional data, as well as haematological, haematochemical, immunological and genetic parameters of an exceptional individual: Antonino Turturici, a semi-supercen…
View article: Diagnosis of familial hypercholesterolemia in a large cohort of Italian genotyped hypercholesterolemic patients
Diagnosis of familial hypercholesterolemia in a large cohort of Italian genotyped hypercholesterolemic patients Open
View article: Long-term efficacy and safety of lomitapide in patients with familial chylomicronemia syndrome (FCS): Data from the LOCHNES study
Long-term efficacy and safety of lomitapide in patients with familial chylomicronemia syndrome (FCS): Data from the LOCHNES study Open