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View article: Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss
Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss Open
Cisplatin is a widely used and effective anticancer drug. However, it causes permanent sensorineural hearing loss in over 50% of treated patients. There are no FDA-approved therapies to prevent cisplatin-induced hearing loss (CIHL) in adul…
View article: Automated western blot analysis of ototoxin-induced prestin burst in the blood after cyclodextrin exposure
Automated western blot analysis of ototoxin-induced prestin burst in the blood after cyclodextrin exposure Open
In the clinical realm, we primarily rely on audiological measures for diagnosis and surveillance of sensorineural hearing loss (SNHL) and have limited therapeutic options. We have proposed a blood-based biomarker approach to overcome this …
View article: Characterization of ototoxic-induced prestin burst in the blood and implications for developing prestin as an ototoxicity biomarker
Characterization of ototoxic-induced prestin burst in the blood and implications for developing prestin as an ototoxicity biomarker Open
In the clinical realm, we primarily rely on audiological measures for diagnosis and surveillance of sensorineural hearing loss (SNHL) and have limited therapeutic options. We have proposed a blood-based biomarker approach to overcome this …
View article: Intracochlear drug delivery systems: a novel approach whose time has come
Intracochlear drug delivery systems: a novel approach whose time has come Open
There is a growing prevalence of hearing loss across the globe, with over 360 million patients worldwide suffering from this condition. Factors such an increasingly aging population, overexposure t...
View article: Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice
Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice Open
View article: Metabolomic analysis of urine with Nuclear Magnetic Resonance spectroscopy in patients with idiopathic sudden sensorineural hearing loss: A preliminary study
Metabolomic analysis of urine with Nuclear Magnetic Resonance spectroscopy in patients with idiopathic sudden sensorineural hearing loss: A preliminary study Open
View article: The potential use of low-frequency tones to locate regions of outer hair cell loss
The potential use of low-frequency tones to locate regions of outer hair cell loss Open
View article: An analysis of cochlear response harmonics: Contribution of neural excitation
An analysis of cochlear response harmonics: Contribution of neural excitation Open
In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (fTr). In a simulation it is…