Marcelo A. Mori
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View article: eLife Assessment: NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice
eLife Assessment: NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice Open
View article: Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model
Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model Open
Introduction Pseudomonas aeruginosa causes severe healthcare-associated infections. High-risk clones are defined by global dissemination and multidrug resistance, yet virulence is heterogeneous. We sought to map accessory-genome determinan…
View article: eLife Assessment: Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife Assessment: Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline Open
View article: Exploring Latin America one cell at a time
Exploring Latin America one cell at a time Open
View article: Oxidative Phosphorylation in Uncoupled Mitochondria
Oxidative Phosphorylation in Uncoupled Mitochondria Open
Mitochondrial membrane potential is highly dependent on coupled as well as uncoupled respiration. While brown adipose tissue (BAT) mediates non‐shivering thermogenesis (NST), a highly adaptive bioenergetic process critical for energy metab…
View article: eLife Assessment: Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading
eLife Assessment: Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading Open
View article: A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss Open
The emergence of glucagon-like peptide-1 agonists represents a notable advancement in the pharmacological treatment of obesity, yet complementary approaches are essential. Through phenotypic drug discovery, we developed promising nitroalke…
View article: eLife Assessment: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
eLife Assessment: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
View article: eLife Assessment: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
eLife Assessment: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading Open
View article: eLife Assessment: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
eLife Assessment: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading Open
View article: NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity
NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity Open
Brown adipose tissue (BAT) is a highly specialized thermogenic tissue and plays a critical role in controlling energy expenditure and metabolic homeostasis. BAT dysfunction is associated with body weight gain and metabolic disorders in mic…
View article: Obesity‐Induced Metabolic Priming Exacerbates <scp>SARS</scp>‐<scp>CoV</scp>‐2 Inflammation
Obesity‐Induced Metabolic Priming Exacerbates <span>SARS</span>‐<span>CoV</span>‐2 Inflammation Open
Despite the early recognition that individuals living with obesity are more prone to develop adverse outcomes during COVID‐19, the mechanisms underlying these conditions are still unclear. During obesity, an accumulation of free fatty acid…
View article: eLife Assessment: Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs
eLife Assessment: Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs Open
View article: eLife Assessment: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
eLife Assessment: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
View article: 16/8 intermittent fasting in mice protects from diet‐induced obesity by increasing leptin sensitivity and postprandial thermogenesis
16/8 intermittent fasting in mice protects from diet‐induced obesity by increasing leptin sensitivity and postprandial thermogenesis Open
Aims To evaluate the molecular mechanisms involved in intermittent fasting 16/8 (16/8 IF), a widespread dietary practice adopted worldwide that consists of 16 h of fasting and 8 h of feeding. Methods Obese mice were fasted daily from 6 am …
View article: Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment
Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment Open
View article: eLife Assessment: Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity
eLife Assessment: Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity Open
View article: eLife Assessment: Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity
eLife Assessment: Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity Open
View article: eLife Assessment: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
eLife Assessment: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading Open
View article: eLife Assessment: Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease
eLife Assessment: Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease Open
View article: eLife Assessment: Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease
eLife Assessment: Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease Open
View article: Feasibility of intravenous injections of pig plasma extracellular particles into rats — an acute study
Feasibility of intravenous injections of pig plasma extracellular particles into rats — an acute study Open
Background Extracellular particles (EPs), especially small extracellular vesicles (EVs), extracted from young animals are increasingly being studied in animal models as agents for regeneration and rejuvenation, with studies using EPs from …
View article: eLife Assessment: TET2 contributes to gluconeogenesis and pathology of type 2 diabetes
eLife Assessment: TET2 contributes to gluconeogenesis and pathology of type 2 diabetes Open
View article: eLife Assessment: Functional identification of soluble uric acid as an endogenous inhibitor of CD38
eLife Assessment: Functional identification of soluble uric acid as an endogenous inhibitor of CD38 Open
View article: eLife Assessment: Nuclear Argonaute protein NRDE-3 switches small RNA binding partners during embryogenesis coincident with the formation of SIMR granules
eLife Assessment: Nuclear Argonaute protein NRDE-3 switches small RNA binding partners during embryogenesis coincident with the formation of SIMR granules Open
View article: eLife Assessment: Functional identification of soluble uric acid as an endogenous inhibitor of CD38
eLife Assessment: Functional identification of soluble uric acid as an endogenous inhibitor of CD38 Open
View article: eLife Assessment: Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease
eLife Assessment: Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease Open
View article: IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat Open
View article: eLife assessment: Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction
eLife assessment: Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction Open
View article: eLife Assessment: Circular RNA HMGCS1 sponges miR-4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction
eLife Assessment: Circular RNA HMGCS1 sponges miR-4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction Open
Noncoding RNA plays a pivotal role as novel regulators of endothelial cell function. Type 2 diabetes, acknowledged as a primary contributor to cardiovascular diseases, plays a vital role in vascular endothelial cell dysfunction due to indu…