Marcelo Falchetti
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View article: Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4 <sup>+</sup> T cells and induce regulatory T cell fate
Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4 <sup>+</sup> T cells and induce regulatory T cell fate Open
While professional antigen-presenting cells drive adaptive immunity, atypical cell types can fulfill this role in the bone marrow. Megakaryocytes (MKs) are canonically recognized for platelet production, but recent studies indicate functio…
Dynamic activity of Erg promotes maturation of the hematopoietic system Open
Hematopoiesis changes over the lifetime to adapt to the physiology of development, maturation, and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of certain blood diseases. Several heterochronic regulators of he…
Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome Open
Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity and tumorigenic behaviors. Here, we integrate single-cell RNA-sequencing data from different can…
Subcellular localization of <span>PD‐L1</span> and cell‐cycle‐dependent expression of nuclear <span>PD‐L1</span> variants: implications for head and neck cancer cell functions and therapeutic efficacy Open
The programmed cell death 1 ligand 1 (PD‐L1)/programmed cell death protein 1 (PD‐1) axis is primarily associated with immunosuppression in cytotoxic T lymphocytes (CTLs). However, mounting evidence is supporting the thesis that PD‐L1 not o…
View article: Identification of novel myeloid-derived cell states with implication in cancer outcome
Identification of novel myeloid-derived cell states with implication in cancer outcome Open
Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment response due to their remarkable plasticity and tumorigenic behaviors. We integrated single-cell RNA-Sequencing datasets from seven different…
Prediction of intercellular communication networks using CellComm Open
Intercellular communication is important for tissue development and homeostasis, and when dysregulated contributes to a multitude of pathobiological processes. Cells communicate with each other by several mechanisms, including direct cell-…
Bioprinting of Adult Dorsal Root Ganglion (DRG) Neurons Using Laser-Induced Side Transfer (LIST) Open
Cell bioprinting technologies aim to fabricate tissuelike constructs by delivering biomaterials layer-by-layer. Bioprinted constructs can reduce the use of animals in drug development and hold promise for addressing the shortage of organs …