Marcelo Folhadella M. F. Azevedo
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View article: Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids
Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids Open
Aim: The development of selective and potent antitumor agents remains a significant challenge. This study aimed to synthesize and evaluate biaryl hydroxy-1,2,3-triazoles and 9H-fluorene-1,2,3-triazole hybrids, inspired by previously identi…
View article: Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy
Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy Open
Background: The potentiator VX-770 (ivacaftor) has been approved as a monotherapy for over 95 cystic fibrosis (CF)-causing variants associated with gating/conductance defects of the CF transmembrane conductance regulator (CFTR) channel. Ho…
View article: In vitro study of the inhibitory potential of hydroxy-1,2,3-triazoles on the replication of ZIKA and chikungunya arboviruses
In vitro study of the inhibitory potential of hydroxy-1,2,3-triazoles on the replication of ZIKA and chikungunya arboviruses Open
Arboviruses, including Zika (ZIKV) and Chikungunya virus (CHIKV), replicate in both arthropods and vertebrates and are transmitted through mosquito, tick, and sandfly bites. The development of specific antiviral drugs and vaccines for thes…
View article: Recovery of Rare Earth Elements from Waste Phosphors Using Phosphonic Acid-Functionalized Silica Adsorbent
Recovery of Rare Earth Elements from Waste Phosphors Using Phosphonic Acid-Functionalized Silica Adsorbent Open
View article: Efficient Synthesis of 4-Acyl-1,2,3-Triazoles from Acetophenones and Aryl Azides: A Synthetic Shortcut for Novel p.Phe508del-CFTR Traffic Correctors
Efficient Synthesis of 4-Acyl-1,2,3-Triazoles from Acetophenones and Aryl Azides: A Synthetic Shortcut for Novel p.Phe508del-CFTR Traffic Correctors Open
View article: Recovery of Rare Earth Elements from Acidic Leaching Solution of the Red Lamp Phosphor Waste Using Phosphonic Acid-Functionalized Silica Adsorbent
Recovery of Rare Earth Elements from Acidic Leaching Solution of the Red Lamp Phosphor Waste Using Phosphonic Acid-Functionalized Silica Adsorbent Open