Marcelo Sobral da Silva
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View article: Target Isolation of Prenylated Isoflavonoids and Pterocarpans from <i>Acosmium diffusissimum</i> Using LC–MS/MS-Based Molecular Networking
Target Isolation of Prenylated Isoflavonoids and Pterocarpans from <i>Acosmium diffusissimum</i> Using LC–MS/MS-Based Molecular Networking Open
This is the report of the HPLC-MSn-guided isolation of new anti-inflammatory prenylated isoflavonoids and pterocarpans from the stems of Acosmium diffusissimum using GNPS molecular networking as the main tool. Cluster analysis guide…
View article: Optimized and Functionalized Carvacrol-Loaded Nanostructured Lipid Carriers for Enhanced Cytotoxicity in Breast Cancer Cells
Optimized and Functionalized Carvacrol-Loaded Nanostructured Lipid Carriers for Enhanced Cytotoxicity in Breast Cancer Cells Open
Background/Objectives: Carvacrol, a monoterpenoid phenol found in essential oils, exhibits many biological activities, including anticancer properties through mechanisms such as induction of apoptosis. These properties can be enhanced if e…
View article: Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview
Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview Open
Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins. The vast diversity of snake species and their venom complexities u…
View article: CHEMICAL CONSTITUENTS FROM THE LEAVES OF Eriodictyon californicum (Hook. & Arn.) Torr. (Boraginaceae)
CHEMICAL CONSTITUENTS FROM THE LEAVES OF Eriodictyon californicum (Hook. & Arn.) Torr. (Boraginaceae) Open
Eriodictyon californicum is a species belonging to Boraginaceae family, popularly known as “yerba santa” and used in folk medicine to treat rheumatism, headaches, inflammation, and respiratory complications. In the present work, we perform…
View article: Synergistic Antimicrobial Effects of Coffee Green Extract and Oil Microemulsions Enhanced by Photodynamic Therapy: A Strategy Against Antibiotic Resistance
Synergistic Antimicrobial Effects of Coffee Green Extract and Oil Microemulsions Enhanced by Photodynamic Therapy: A Strategy Against Antibiotic Resistance Open
View article: Chemotaxonomic Analysis of Diterpenes in Four Euphorbiaceae Genera: A Path to New Cytotoxic Agents
Chemotaxonomic Analysis of Diterpenes in Four Euphorbiaceae Genera: A Path to New Cytotoxic Agents Open
The Euphorbiaceae family is renowned for its diverse array of compounds, primarily diterpenes, which exhibit multiple biological activities. In Brazil, the genera Jatropha, Cnidoscolus, Sapium, and Stillingia are predominantly found in the…
View article: (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms
(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms Open
Background: (-)-Fenchone is a bicyclic monoterpene present in the plant species Foeniculum vulgare Mill, Thuja occidentalis L. (tuja), and Lavandula stoechas (lavender). These plants have therapeutic value in the treatment of intestinal di…
View article: Lignanamides from the Roots of <i>Metternichia macrocalyx</i> and Their Anti-inflammatory Activity
Lignanamides from the Roots of <i>Metternichia macrocalyx</i> and Their Anti-inflammatory Activity Open
Five new lignanamides (1-5) and ten known amides (6-15) were isolated from the chloroform extract of Metternichia macrocalyx roots. The structures of the new compounds were elucidated via analysis of NMR …
View article: AMTAC-19, a Spiro-Acridine Compound, Induces In Vitro Antitumor Effect via the ROS-ERK/JNK Signaling Pathway
AMTAC-19, a Spiro-Acridine Compound, Induces In Vitro Antitumor Effect via the ROS-ERK/JNK Signaling Pathway Open
Colorectal cancer remains a significant cause of mortality worldwide. A spiro-acridine derivative, (E)-1′-((4-bromobenzylidene)amino)-5′-oxo-1′,5′-dihydro-10H-spiro[acridine-9,2′-pyrrole]-4′-carbonitrile (AMTAC-19), showed significant cyto…
View article: Jatropha Diterpenes: An Updated Review Concerning Their Structural Diversity, Therapeutic Performance, and Future Pharmaceutical Applications
Jatropha Diterpenes: An Updated Review Concerning Their Structural Diversity, Therapeutic Performance, and Future Pharmaceutical Applications Open
The Euphorbiaceae family is a rich source of bioactive terpenoids. Among its genera, Jatropha is a conspicuous producer of diterpenes and includes approximately 175 species, many of which have medicinal uses. To date, 140 diterpenes from J…
View article: Cytotoxic potential of new caffeoyl triterpenes from the root of <i>Acosmium diffusissimum</i> (Mohlenbr.) Yakovlev: an <i>in vitro</i> and <i>in silico</i> approach
Cytotoxic potential of new caffeoyl triterpenes from the root of <i>Acosmium diffusissimum</i> (Mohlenbr.) Yakovlev: an <i>in vitro</i> and <i>in silico</i> approach Open
Two new caffeoyl triterpenes, cis-lupacosmeol (1) alone and in mixture with trans-lupacosmeol (2), and two known compounds, 16β-hydroxy-3β-trans-caffeoyl-olean-12-ene (3) and 16β-hydroxy-3β-p-coumaroyl-lup-20(29)-ene (…
View article: MATRIZ GUT
MATRIZ GUT Open
View article: Potential <i>In Vitro</i> Antimelanoma Effect of the Essential Oil from <i>Croton grewioides</i> Baill
Potential <i>In Vitro</i> Antimelanoma Effect of the Essential Oil from <i>Croton grewioides</i> Baill Open
Cancer is a group of diseases characterized by uncontrolled cell growth, invasive capacity, and metastatic potential. Despite the continual progress in cancer treatment, high toxicity and resistance to therapy remain recurring challenges. …
View article: Integrative investigation of the potential impacts of Pilosocereus gounellei (A. Weber ex K. Schum. Bly. Ex Rowl) cladodes on the human intestinal microbiota
Integrative investigation of the potential impacts of Pilosocereus gounellei (A. Weber ex K. Schum. Bly. Ex Rowl) cladodes on the human intestinal microbiota Open
Pilosocereus gounellei A. Weber ex K. Schum. Bly. Ex Rowl (xique-xique) is a cactus native to the Brazilian Caatinga biome and considered a non-conventional food plant. This study evaluated the physicochemical characteristics, antioxidant …
View article: Monnieriside A from <i>Evolvulus linarioides</i> promotes antinociceptive effects in models of inflammatory and postoperative pain in male mice
Monnieriside A from <i>Evolvulus linarioides</i> promotes antinociceptive effects in models of inflammatory and postoperative pain in male mice Open
Monnieriside A (MoA) is a chromone isolated from Evolvulus linarioides. This study investigated the antinociceptive potential of MoA in mice. MoA (0.01–100 mg/kg, i.p.) inhibited nociception in the inflammatory phase of the formalin…
View article: Evaluating the potential prebiotic effects of umbu-cajá (Spondias spp.) fruit processing by-product flour on the human intestinal microbiota
Evaluating the potential prebiotic effects of umbu-cajá (Spondias spp.) fruit processing by-product flour on the human intestinal microbiota Open
View article: Abietane Diterpenes from Medusantha martiusii and Their Anti-Neuroinflammatory Activity
Abietane Diterpenes from Medusantha martiusii and Their Anti-Neuroinflammatory Activity Open
Seven new abietane diterpenoids, comprising medusanthol A–G (1–3, 5, 7–9) and two previously identified analogs (4 and 6), were isolated from the hexane extract of the aerial parts of Medusantha martiusii. The structures of the compounds w…
View article: Exploring the potential prebiotic effects of Opuntia dillenii (Ker Gawl). Haw (Cactaceae) cladodes on human intestinal microbiota
Exploring the potential prebiotic effects of Opuntia dillenii (Ker Gawl). Haw (Cactaceae) cladodes on human intestinal microbiota Open
This study evaluated the physicochemical properties, antioxidant capacity, and potential prebiotic effects on the human intestinal microbiota of freeze-dried Opuntia dillenii (Ker Gawl). Haw] (Cactaceae) cladodes (FDOd). FDOd had high leve…
View article: Fermenting Acerola (Malpighia emarginata D.C.) and Guava (Psidium guayaba L.) Fruit Processing Co-Products with Probiotic Lactobacilli to Produce Novel Potentially Synbiotic Circular Ingredients
Fermenting Acerola (Malpighia emarginata D.C.) and Guava (Psidium guayaba L.) Fruit Processing Co-Products with Probiotic Lactobacilli to Produce Novel Potentially Synbiotic Circular Ingredients Open
This study evaluated the effects of acerola and guava fruit processing co-products fermented with probiotic Lactobacillus acidophilus LA-05 and Lacticaseibacillus paracasei L-10 on the abundance of different intestinal bacterial groups and…
View article: Integrity Analysis of Polyamide 12 Applied in Oil Pipelines
Integrity Analysis of Polyamide 12 Applied in Oil Pipelines Open
Pipes of polyamide were installed in oil fields and, after one year of operation, were removed and analyzes were carried out to assess any degradation and study its use in oil pipelines as corrosion mitigation. The outer layers of all fiel…
View article: The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone
The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone Open
View article: ALCALOIDES SESQUITERPÊNICOS ISOLADOS DE Maytenus distichophylla (CELASTRACEAE)
ALCALOIDES SESQUITERPÊNICOS ISOLADOS DE Maytenus distichophylla (CELASTRACEAE) Open
SESQUITERPENES ALKALOIDS FROM Maytenus distichophylla (CELASTRACEAE). The phytochemical study of the roots of Maytenus distichophylla Mart. ex Reissek (Celastraceae), resulted in the isolation of the seven sesquiterpenes pyridine alkaloids…
View article: Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAB and Muscarinic Receptors
Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAB and Muscarinic Receptors Open
Cleomin, a 1,3-oxazolidine-2-thione, was recently isolated from Neocalyptrocalyx longifolium, a species traditionally used for treating painful conditions. Reports about the pharmacological activities of cleomin are lacking. Here, the anti…
View article: The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways Open
The characterization and cytotoxicity of the essential oil from Conyza bonariensis (L.) aerial parts (CBEO) were previously conducted. The major compound was (Z)-2-lachnophyllum ester (EZ), and CBEO exhibited significant ROS-dependent cyto…
View article: CCDC 2193776: Experimental Crystal Structure Determination
CCDC 2193776: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Chemical Composition, In Vitro Antitumor Effect, and Toxicity in Zebrafish of the Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae)
Chemical Composition, In Vitro Antitumor Effect, and Toxicity in Zebrafish of the Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Open
The essential oil from Conyza bonariensis (Asteraceae) aerial parts (CBEO) was extracted by hydrodistillation in a Clevenger-type apparatus and was characterized by gas chromatography–mass spectrometry. The antitumor potential was evaluate…
View article: Novel Phenylpropanoid Derivative from Euploca procumbens (Mill.) Diane & Hilger with Potential Anti-Inflammatory Activity
Novel Phenylpropanoid Derivative from Euploca procumbens (Mill.) Diane & Hilger with Potential Anti-Inflammatory Activity Open
A new phenylpropanoid derivative, named euploic acid (1), was isolated from Euploca procumbens (Mill.) Diane & Hilger, Boraginaceae, along with lithospermic acid B (2), lithospermic acid (3), 9’’-methyl lithospermate (4), and luteolin-7-O-…
View article: Mass Spectrometry-Based Investigation of Sugarcane Exposed to Five Different Pesticides
Mass Spectrometry-Based Investigation of Sugarcane Exposed to Five Different Pesticides Open
The use of agrochemicals has become a standard practice worldwide to ensure the productivity and quality of sugarcane crops. This study aimed to analyze the metabolic changes in sugarcane culms treated with five different nematicides. The …
View article: Antimicrobial Potential of Betulinic Acid and Investigation of the Mechanism of Action against Nuclear and Metabolic Enzymes with Molecular Modeling
Antimicrobial Potential of Betulinic Acid and Investigation of the Mechanism of Action against Nuclear and Metabolic Enzymes with Molecular Modeling Open
Natural products have important pharmacological activities. This study sought to investigate the activity of the compound betulinic acid (BA) against different strains of bacteria and fungi. The minimum inhibitory concentration (MIC) was d…
View article: Novel Tritepene Saponins from Mandacaru (Cereus jamacaru)
Novel Tritepene Saponins from Mandacaru (Cereus jamacaru) Open
Mandacaru (Cereus jamacaru) is a Cactaceae species widely used as food and for medicinal purposes in Brazilian's northeastern region.Nevertheless, only a few alkaloids were identified from this plant.Hence, the knowledge regarding their ch…