Marcia L. Feldkamp
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View article: Comorbidity and Multimorbidity in Adults With Congenital Heart Disease: Findings From a Multi‐Site Population‐Based Study
Comorbidity and Multimorbidity in Adults With Congenital Heart Disease: Findings From a Multi‐Site Population‐Based Study Open
Background Survival of individuals with congenital heart disease (CHD) has improved, leading to a growing and aging population of adults living with these conditions. Over their lifetime, they often face an array of comorbidities that affe…
View article: Racial and Ethnic Disparities in Health Care Usage and Death by Neighborhood Poverty Among Individuals With Congenital Heart Defects, 4 US Surveillance Sites, 2011 to 2013
Racial and Ethnic Disparities in Health Care Usage and Death by Neighborhood Poverty Among Individuals With Congenital Heart Defects, 4 US Surveillance Sites, 2011 to 2013 Open
Background Socioeconomic factors may lead to a disproportionate impact on health care usage and death among individuals with congenital heart defects (CHD) by race, ethnicity, and socioeconomic factors. How neighborhood poverty affects rac…
View article: Gastroschisis prevalence patterns in 27 surveillance programs from 24 countries, International Clearinghouse for Birth Defects Surveillance and Research, 1980–2017
Gastroschisis prevalence patterns in 27 surveillance programs from 24 countries, International Clearinghouse for Birth Defects Surveillance and Research, 1980–2017 Open
Background Gastroschisis is a serious birth defect with midgut prolapse into the amniotic cavity. The objectives of this study were to evaluate the prevalence and time trends of gastroschisis among programs in the International Clearinghou…
View article: Regulatory elements in SEM1-DLX5-DLX6 (7q21.3) locus contribute to genetic control of coronal nonsyndromic craniosynostosis and bone density-related traits
Regulatory elements in SEM1-DLX5-DLX6 (7q21.3) locus contribute to genetic control of coronal nonsyndromic craniosynostosis and bone density-related traits Open
Our findings support a polygenic nature of cNCS risk and functional role of craniofacial enhancers in cNCS susceptibility with potential broader implications for bone health.
View article: Racial and Ethnic Disparities in Healthcare Utilization and Mortality by Neighborhood Poverty among Individuals with Congenital Heart Defects, four U.S. Surveillance Sites, 2011-2013
Racial and Ethnic Disparities in Healthcare Utilization and Mortality by Neighborhood Poverty among Individuals with Congenital Heart Defects, four U.S. Surveillance Sites, 2011-2013 Open
BACKGROUND Socioeconomic factors may lead to a disproportionate impact on healthcare utilization and mortality among individuals with congenital heart defects (CHD) by race, ethnicity, and socio-economic factors. How neighborhood poverty a…
View article: Neighborhood Deprivation and Neural Tube Defects
Neighborhood Deprivation and Neural Tube Defects Open
Background: Individual measures of socioeconomic status (SES) have been associated with an increased risk of neural tube defects (NTDs); however, the association between neighborhood SES and NTD risk is unknown. Using data from the Nationa…
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View article: Neighborhood-level Socioeconomic Position During Early Pregnancy and Risk of Gastroschisis
Neighborhood-level Socioeconomic Position During Early Pregnancy and Risk of Gastroschisis Open
Background: Neighborhood-level socioeconomic position has been shown to influence birth outcomes, including selected birth defects. This study examines the un derstudied association between neighborhood-level socioeconomic position during …
View article: Exome‐wide assessment of isolated biliary atresia: A report from the <scp>National Birth Defects Prevention Study</scp> using child–parent trios and a case–control design to identify novel rare variants
Exome‐wide assessment of isolated biliary atresia: A report from the <span>National Birth Defects Prevention Study</span> using child–parent trios and a case–control design to identify novel rare variants Open
The etiology of biliary atresia (BA) is unknown, but recent studies suggest a role for rare protein‐altering variants (PAVs). Exome sequencing data from the National Birth Defects Prevention Study on 54 child–parent trios, one child–mother…
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View article: Exome-wide assessment of isolated biliary atresia: A report from the National Birth Defects Prevention Study using child–parent trios and a case–control design to identify novel rare variants
Exome-wide assessment of isolated biliary atresia: A report from the National Birth Defects Prevention Study using child–parent trios and a case–control design to identify novel rare variants Open
The etiology of biliary atresia (BA) is unknown, but recent studies suggest a role for rare protein-altering variants (PAVs). Exome sequencing data from the National Birth Defects Prevention Study on 54 child–parent trios, one child–mother…
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View article: Parents’ report on the health care management of spina bifida in early childhood
Parents’ report on the health care management of spina bifida in early childhood Open
PURPOSE: This study aimed to describe health care use by type of health providers and care settings visited by children with spina bifida (SB) and to compare this use between children with and without a shunt. METHODS: Health care use data…
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View article: Prevalence and mortality among children with anorectal malformation: A <scp>multi‐country</scp> analysis
Prevalence and mortality among children with anorectal malformation: A <span>multi‐country</span> analysis Open
Purpose We examined the total prevalence, trends in prevalence, and age‐specific mortality among individuals with anorectal malformation ( ARM ) Methods We conducted a retrospective cohort study using data from 24 population‐ and hospital‐…
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View article: Health Care Usage Among Adolescents With Congenital Heart Defects at 5 Sites in the United States, 2011 to 2013
Health Care Usage Among Adolescents With Congenital Heart Defects at 5 Sites in the United States, 2011 to 2013 Open
Background We sought to characterize health care usage for adolescents with congenital heart defects (CHDs) using population‐based multisite surveillance data. Methods and Results Adolescents aged 11 to 18 years with ≥1 CHD‐related diagnos…
View article: Interaction of maternal medication use with ambient heat exposure on congenital heart defects in the National Birth Defects Prevention Study
Interaction of maternal medication use with ambient heat exposure on congenital heart defects in the National Birth Defects Prevention Study Open
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View article: A Multicountry Analysis of Prevalence and Mortality among Neonates and Children with Bladder Exstrophy
A Multicountry Analysis of Prevalence and Mortality among Neonates and Children with Bladder Exstrophy Open
Objective Bladder exstrophy (BE) is a rare but severe birth defect affecting the lower abdominal wall and genitourinary system. The objective of the study is to examine the total prevalence, trends in prevalence, and age-specific mortality…
View article: Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects
Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects Open
Objectives: To explore associations between maternal pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects. Design: This is a population-based, case–control study using maternal responses to a dietary assessment and publi…
View article: Exome sequencing identifies variants in infants with sacral agenesis
Exome sequencing identifies variants in infants with sacral agenesis Open
Background Sacral agenesis (SA) consists of partial or complete absence of the caudal end of the spine and often presents with additional birth defects. Several studies have examined gene variants for syndromic forms of SA, but only one ha…
View article: Exome sequencing identifies variants in infants with sacral agenesis
Exome sequencing identifies variants in infants with sacral agenesis Open
Background: Sacral agenesis (SA) consists of partial or complete absence of the caudal end of the spine and often presents with additional birth defects. Several studies have examined gene variants for syndromic forms of SA, but only one h…
View article: Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects: A U.S. population-based case-control study in the National Birth Defects Prevention Study
Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects: A U.S. population-based case-control study in the National Birth Defects Prevention Study Open
Background/objective: Research suggests gestational exposure to particulate matter ≤2.5 μm (PM2.5) and extreme heat may independently increase risk of birth defects. We investigated whether duration of gestational extreme heat exposure mod…
View article: Exome sequencing identifies genetic variants in anophthalmia and microphthalmia
Exome sequencing identifies genetic variants in anophthalmia and microphthalmia Open
Anophthalmia and microphthalmia (A/M) are rare birth defects affecting up to 2 per 10,000 live births. These conditions are manifested by the absence of an eye or reduced eye volumes within the orbit leading to vision loss. Although clinic…
View article: Site, frequency, and duration of pain in young children with spina bifida
Site, frequency, and duration of pain in young children with spina bifida Open
PURPOSE: To investigate the: (1) percent of children with spina bifida (SB) complaining of pain, (2) frequency, duration, and cause of pain by sex, level of lesion type of SB, and ambulation status, (3) body sites reported to hurt, by vari…
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View article: Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects
Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects Open
BACKGROUND AND AIM: Previous research suggests gestational exposure to particulate matter ≤ 2.5 μm (PM2.5) and extreme heat may independently increase risk of birth defects. We investigated whether duration of gestational extreme heat expo…